Scientist I

6 days ago


Waltham, United States Pyramid Consulting, Inc Full time

Immediate need for a talented Scientist I. This is a 09+months contract opportunity with long-term potential and is located in Waltham, MA (Onsite). Please review the job description below and contact me ASAP if you are interested.


Job ID:24-52708

Pay Range: $55 - $59/hour. Employee benefits include, but are not limited to, health insurance (medical, dental, vision), 401(k) plan, and paid sick leave (depending on work location).


Key Responsibilities:


  • Maintain cultures of immortalized tumor cell lines, hepatic primary cell types (e.g. hepatocytes, LSEC and KC).
  • Perform hepatocytes mouse isolation from key disease models.
  • Optimize, design, execute, and interpret in vitro cell-based assays to characterize diverse mechanisms of gene therapies (e.g. ELISA, MSD, high content imaging)
  • Perform fit-for-purpose in vitro and ex vivo assays to assess phenotypic and functional read-outs to assess drug candidate toxicity and efficacy.
  • Prepare experimental protocols, analyze experimental data, and present study results in team and department meetings.
  • Document experimental methods and findings in electronic laboratory notebook.
  • Conduct and interpret cell-based in vitro assays to characterize mechanism of action related to non-viral gene therapy with focus on the hepatic environment:
  • Immunomodulation.
  • Cargo cell localization.
  • Support non-viral (LNP) oligo therapy screenings e.g. endosomal scape assessment.


Key Requirements and Technology Experience:


  • Key Skills:hepatocytes, Proliferation, Liver biology .
  • Demonstrated expertise with standard aseptic cell culture technique, including experience culturing various primary cells.
  • Experience with hepatocytes primary cell culture is highly appreciated. Experience with hepatocytes and/or liver non-parenchymal cells isolation is a plus.
  • Broad experience with cell-based functional assays, including transfection, cytotoxicity, cytokine release, and proliferation assays.
  • Experience with co-culture in-vitro or MPS is a plus.
  • Proficiency across cellular, biochemical, and molecular techniques including protein detection (ELISA, MSD, western blot), gene profiling (RNA/DNA extraction, qPCR) and cell imaging.
  • Experience with high content microscopy is a plus.
  • Broad scientific knowledge in liver biology and non-viral delivery and molecular biology.
  • Self-motivated with strong time management and organizational skills.
  • Flexibility to rapidly changing priorities and deadlines.
  • Experience in preparing high quality documents including technical reports, presentations, SOPs, and experimental protocols.
  • Highly collaborative with demonstrated ability to work in a matrixed team environment.
  • Excellent oral and written communication skills.


Our client is a leading Pharmaceutical Industry, and we are currently interviewing to fill this and other similar contract positions. If you are interested in this position, please apply online for immediate consideration.


Pyramid Consulting, Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, colour, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.


By applying to our jobs you agree to receive calls, AI-generated calls, text messages, or emails from Pyramid Consulting, Inc. and its affiliates, and contracted partners. Frequency varies for text messages. Message and data rates may apply. Carriers are not liable for delayed or undelivered messages. You can reply STOP to cancel and HELP for help. You can access our privacy policy here.



  • Waltham, Massachusetts, United States Dyne Tx Full time

    Job Title: Senior Bioinformatics Data ScientistAt Dyne Therapeutics, we're dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. As a Senior Bioinformatics Data Scientist, you'll be a critical contributor to our data analytics and engineering efforts, accelerating our R&D programs and expanding...


  • Waltham, United States Xilio Therapeutics Full time

    Principal Scientist, Computational Biotherapeutics Engineering Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using...


  • Waltham, United States Atlas Venture Full time

    Principal Scientist, Computational Biotherapeutics EngineeringCompany Address: 828 Winter St, Waltham, Massachusetts 02451, US About Xilio TherapeuticsFocused on harnessing the immune system to achieve deep and durable clinical responses to improve the lives of patients.Job DescriptionXilio Therapeutics is a clinical-stage biotechnology company discovering...

  • Senior Scientist

    3 days ago


    Waltham, MA, United States Xilio Therapeutics Full time

    Senior Scientist / Principal Scientist, Biotherapeutic Engineering Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is...

  • Principal Scientist

    4 weeks ago


    Waltham, United States Apellis Pharmaceuticals Full time

    Position Summary: We are seeking a talented and highly motivated individual to join the DMPK/Bioanalysis group at Apellis Pharmaceuticals in Waltham, MA. The main responsibility for this position is to outsource and manage non-clinical and clinical PD (biomarker) bioanalysis. This includes managing novel PD method development and validation for various...


  • Waltham, MA, United States GlaxoSmithKline Full time

    Site Name: Durham Blackwell Street, Upper Providence, WalthamPosted Date: Nov 13 2024GSK has an inspiring ambition: by uniting science, technology and talent we aim to positively impact the health of 2.5 billion people over the next ten years. We will get ahead of disease together with our R&D approach of focusing on the science of the immune system, human...


  • Waltham, United States Ventus Therapeutics Full time

    About us:Ventus Therapeutics is a clinical-stage biopharmaceutical company deploying leading-edge structural biology and computational chemistry tools to create novel small molecule medicines for challenging targets in immunology, inflammation, and neurology. Our proprietary drug discovery platform, ReSOLVE, gives us the ability to discover and develop...


  • waltham, United States Ventus Therapeutics Full time

    About us:Ventus Therapeutics is a clinical-stage biopharmaceutical company deploying leading-edge structural biology and computational chemistry tools to create novel small molecule medicines for challenging targets in immunology, inflammation, and neurology. Our proprietary drug discovery platform, ReSOLVE, gives us the ability to discover and develop...


  • Waltham, United States CSL Seqirus Full time

    The Opportunity:The TA Lead has significant responsibility and impact. The position will be instrumental in forming strategic partnerships with the respective business leads/TA leads. The TA Lead will lead and oversee the global management of intellectual property matters as well as provide strategic guidance to advance the TA IP assets and creating...


  • Waltham, United States CSL Seqirus Full time

    Job DescriptionThe Opportunity:The TA Lead has significant responsibility and impact. The position will be instrumental in forming strategic partnerships with the respective business leads/TA leads. The TA Lead will lead and oversee the global management of intellectual property matters as well as provide strategic guidance to advance the TA IP assets and...


  • Waltham, United States CSL Seqirus Full time

    The Opportunity:The TA Lead has significant responsibility and impact. The position will be instrumental in forming strategic partnerships with the respective business leads/TA leads. The TA Lead will lead and oversee the global management of intellectual property matters as well as provide strategic guidance to advance the TA IP assets and creating...


  • Waltham, United States CSL Seqirus Full time

    The Opportunity:The TA Lead has significant responsibility and impact. The position will be instrumental in forming strategic partnerships with the respective business leads/TA leads. The TA Lead will lead and oversee the global management of intellectual property matters as well as provide strategic guidance to advance the TA IP assets and creating...


  • Waltham, MA, United States GSK Full time

    Full job description Site Name: UK - Hertfordshire - Stevenage, GSK HQ, Upper Providence, USA - Massachusetts - Waltham, Warsaw Rzymowskiego 53, Zug HousePosted Date: Dec 4 2024Are you interested in a leadership opportunity to drive the implementation of effective Clinical Oncology strategies for a multi-national pharmaceutical company? If so, this role...


  • Waltham, MA, United States CSL Seqirus Full time

    The Opportunity:The TA Lead has significant responsibility and impact. The position will be instrumental in forming strategic partnerships with the respective business leads/TA leads. The TA Lead will lead and oversee the global management of intellectual property matters as well as provide strategic guidance to advance the TA IP assets and creating...


  • North Waltham, United States CSL Seqirus Full time

    The Opportunity:The TA Lead has significant responsibility and impact. The position will be instrumental in forming strategic partnerships with the respective business leads/TA leads. The TA Lead will lead and oversee the global management of intellectual property matters as well as provide strategic guidance to advance the TA IP assets and creating...


  • Waltham, Massachusetts, 02452, Middlesex County, MA, United States CSL Seqirus Full time

    The Opportunity:The TA Lead has significant responsibility and impact. The position will be instrumental in forming strategic partnerships with the respective business leads/TA leads. The TA Lead will lead and oversee the global management of intellectual property matters as well as provide strategic guidance to advance the TA IP assets and creating...


  • Waltham, MA, United States Ventus Therapeutics Full time

    About us:Ventus Therapeutics is a clinical-stage biopharmaceutical company deploying leading-edge structural biology and computational chemistry tools to create novel small molecule medicines for challenging targets in immunology, inflammation, and neurology. Our proprietary drug discovery platform, ReSOLVE, gives us the ability to discover and develop...


  • Waltham, MA, United States CSL Seqirus Full time

    The Opportunity:The TA Lead has significant responsibility and impact. The position will be instrumental in forming strategic partnerships with the respective business leads/TA leads. The TA Lead will lead and oversee the global management of intellectual property matters as well as provide strategic guidance to advance the TA IP assets and creating...