Lab Technician, PRISM

4 weeks ago

Cambridge, United States Skills Alliance Full time

JOB TITLE

Lab Technician, PRISM

JOB DESCRIPTION

Our client's PRISM team, a core group of the Cancer Program, is seeking an exceptional candidate to join our dynamic and growing research team. This position affords the exciting opportunity to join our multidisciplinary team to assist with high-throughput cell line screening and the development of new screening technologies and to contribute to our goal of finding novel cancer treatments.


The PRISM technology allows us to routinely profile over 900 DNA-barcoded cell lines with hundreds of therapeutics in a pooled format much more rapidly than traditional cell line screening. The power of PRISM is realized through our vast understanding of the underlying genomic features of the cell lines: every single therapeutic tested with PRISM delivers not only viability information but also a wealth of genomic correlations and multivariate analyses to provide a holistic understanding of drug behavior. We use these features to help identify off-target effects, patient populations, biomarkers of response and resistance, and much more.



We are seeking an experienced Lab Technician to join our Next Gen Cells & Model Dev group on the PRISM team. As a Lab Technician, you will play a crucial role in supporting our scientific research by preparing various materials for laboratory activities, mixing 20-25 cell lines for our assay, assisting in the execution of PRISM collaborator screens and experiments to improve and optimize our screening workflow, ensuring our cell lines are properly stored, and maintaining a sterile environment within the lab. You will be expected to have a broad cell-culture background, be extremely organized, have a high attention to detail, and have high-quality standards. You will be part of a team and must have great communication skills. Our client provides a vibrant research environment with close links to top academic institutions across the Boston Area. It provides the potential for your contributions to be used and recognized worldwide.


Primary Responsibilities:

Cell biologist with the ability to culture and mix multiple mammalian cell lines at a time (about 25-35 lines at one time).

Implement barcoding procedures to maintain traceability and organization of samples within the biorepository.

High-throughput screening as part of a team, including use of automation equipment

Conduct quality control checks on samples, ensuring accuracy and consistency in experimental results.

Document and compile data in an electronic notebook

Standard lab maintenance work to ensure the functionality of lab equipment and maintain lab supply

Participate in internal and external team meetings to share results and plan experiments


Other responsibilities:

Perform cell viability analysis using microscopy and other relevant techniques.

Conduct experimental tests under the supervision of a senior scientist, contributing to ongoing research initiatives.



Requirements

Bachelor’s degree in Biology or related field with 1-4 years of cell culture and molecular biology experience

Proficiency in basic lab operations and techniques, with hands-on experience in laboratory activities.

Knowledge of high-throughput screening and automation is desired, but not required

Basic computer skills including Google Drive, Microsoft Excel, and Microsoft Word are required

Experience with basic molecular biology techniques and biochemical assays including PCR, DNA and RNA extractions, Western blot, and cell viability assays

Strong attention to detail and organizational skills, with the ability to maintain accurate records and documentation.

Must be an exceptional team player with a high level of initiative to work in a fast-paced environment


Our client will not offer visa sponsorship for this opportunity.

EOE/Minorities/Females/Protected Veterans/Disabilities

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