Scientist

1 month ago


South San Francisco, United States Skills Alliance Full time

About the Role:

As a Scientist reporting into the Head of Preclinical you will design, execute, and analyze experiments from therapeutic target evaluation to developmental candidate nomination. This position will be heavily on the bench, and you will be working in close collaboration with our therapeutic program and platform technology teams, you will:

• Onboard and validate disease-specific in vitro cellular models.

• Build improved CRISPR-Cas-related and novel systems that enable therapeutic genome engineering

• Assess the functional impact of therapeutic genome engineering candidates using appropriate in vitro model systems.

• Coordinate biomarker assay development and execution of bioanalytical assays and other study read-outs, working with both internal and external resources.

• Ensure the proper documentation and interpretation of study results and the preparation of scientific reports and presentations for internal and external audiences.

• In all cases, you will ensure that study design and execution aligns with the company's research goals, timelines, and budgets.


Requirements:

• A Ph.D. in neuroscience, pharmacology, physiology, drug delivery, genetics or a related life sciences discipline, with >3 years of biotechnology or drug development experience.

• In depth knowledge of iPSC-derived models in drug development and experience in applying these models to preclinical studies.

• Ability to think creatively and drive for success in a fast paced and agile work environment.

• An experimentalist ready and able to drive to the full cycle of design/build/test/analyze.

• Strong understanding of cell engineering and tissue culture best practices.

• Experience working with gene editing and/or gene therapy applications, including refinement of core technology for specific targets.


Preferred Qualifications:

• In-depth knowledge of neuroscience •

Demonstrated ability to work in multi-disciplinary teams to achieve experimental objectives

• Experience working with patient-derived iPSCs and protocols for neuronal and/or cardiac cell differentiation.

• Experience working in dynamic startup and/or small company environments that necessitate pitching in and assisting with a wide variety of important tasks.

• A desire to create effective policies and procedures from the ground up.


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