Senior Research Associate/Associate Scientist in Protein Analytics

4 weeks ago

Cambridge, United States Crossbow Therapeutics, Inc Full time

The (Sr) Research Associate/Associate Scientist will join efforts of Antibody Discovery, Protein Engineering and Process Development team to develop safe and effective T-cell engager therapies. The candidate will have an opportunity to contribute to groundbreaking research working with a team of enthusiastic scientists.

Key Responsibilities:


  • Perform protein characterization using multiple biophysical and biochemical techniques (i.e. SEC, HIC, IEX, SDS-PAGE, BLI), as well as other assessment tools.
  • Perform stability assessment of proteins (antibodies and antigens)
  • Support the development, optimization, and troubleshooting of analytical methods for protein characterization.
  • Maintain and troubleshoot analytical equipment.
  • Perform protein purification from bacterial protein expression system and further protein analysis and characterization.
  • Maintain well-organized electronic notebook records of experimental data, author technical protocols and reports, communicate experimental results to the team.
  • Collaborate with other scientists to support the development of innovative testing technologies.


Qualifications:

  • Bachelor's or Master's degree in Biochemistry, Chemistry, or a related field with a minimum of 2 years of protein characterization experience
  • Working technical expertise in analytical methodologies used to characterize protein therapeutics including SEC, IEX, HIC, CE-SDS, SDS-PAGE, etc.
  • Experience with characterization of protein-protein interactions (BLI, ELISA)
  • Experience in protein purification from bacterial protein expression system.
  • Experience handling, maintaining, and troubleshooting LC instruments (Agilent)
  • Experience with LC data analysis and interpretation.
  • Ability to work in a matrix team environment.
  • Excellent written and oral communication skills
  • Experience using electronic notebooks (Benchling)

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