Research Associate II/Senior Research Associate, Upstream Process Development
2 weeks ago
About Enlaza Therapeutics
Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a disruptive new class of biologic therapeutics. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.
Role Description:
As part of the Upstream Process Development Team, the Research Associate is expected to assist in conducting experiments to define robust bioreactor processes to produce protein biologics from E. coli and help develop scalable processes suitable for cGMP production.
This role will encompass unit operations which are typically seen in an upstream function and require cross-collaboration with internal platform development along and downstream team members. A successful candidate will have technical knowledge and experience in upstream process development and a drive to learn.
Responsibilities:
• Help plan and execute on key experiments to further Upstream Process Development of the proprietary Enlaza protein production platform
• Maintain UPD group inventory including cell banks, stock solutions, and materials; and troubleshoot processes and equipment
• Contribute to the enhancement of manufacturing technologies, capabilities, and processes through (e.g., optimize media development, bioreactor fed-batch, and scale-up)
• Generate, manage, evaluate, and maintain critical data in a highly organized and timely manner; Maintain and improve ELN templates
• Assist in authoring technical reports, tech transfer documents, and SOP’s
• Prepare scientific presentations as needed. Write/revise SOPs as needed
• Work closely with scientists across functions to produce the proteins required to meet project goals
Qualifications/Requirements:
• BS in Biochemical engineering or Biological Sciences with 1+ years industry experience, or MS.
· Exposure to industrial cell culture process development, primarily with microbial systems
• Hands on experience with small-scale bioreactor set-up and operations, along with flasks
• Proficient laboratory skills, including quantitative sample transfer, consistent and reproducible media preparation and familiarity with molecular biology techniques (e.g. western blots)
• Experience with writing technical documents such as tech transfer documents, SOPs, and progress reports
• Proficient with MS-Excel
Preferred
• Direct experience with E. coli upstream process development for biologics
• Experience with programming reactor control systems
• Experience with cGMP and tech transfer to CDMOs
• Experience with Benchling and JMP
Compensation:
In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.
Job Type:
Full-time
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San Diego, United States Enlaza Therapeutics Full timeAbout Enlaza TherapeuticsEnlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a disruptive new class of biologic therapeutics. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.Role Description:As part of the Upstream Process...
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