Protein & Molecular Biology Lead

4 weeks ago

Philadelphia, United States GQR Full time

Associate Director/Director, Protein & Molecular Biology

Philadelphia, PA

COMPANY is a clinical-stage biotechnology company focused on the discovery and development of engineered T cell therapies that have the potential to provide a deep and durable, perhaps curative, treatment for patients with autoimmune diseases. The CABA™ platform encompasses two strategies: the CARTA (chimeric antigen receptor T cells for autoimmunity) strategy, with CABA-201, a 4-1BB-containing fully human CD19-CAR T, as the lead product candidate being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis, and the CAART (chimeric autoantibody receptor T cells) strategy, with multiple clinical-stage candidates, including DSG3-CAART for mucosal pemphigus vulgaris and MuSK-CAART for MuSK myasthenia gravis. The expanding CABA™ platform is designed to develop potentially curative therapies that offer deep and durable responses for patients with a broad range of autoimmune diseases. COMPANY’s headquarters and labs are in Philadelphia, PA.


About the Position

Reporting to the Vice President, Preclinical Research we are seeking an experienced and motivated Associate Director/Director. The successful candidate will collaborate with cross-functional teams (Cellular Immunology, Pharmacology, CMC, etc.) to advance the current research pipeline including support and participation in ongoing preclinical IND enabling studies. Additionally, they will oversee and lead a team of individuals supporting research core operations (e.g. Plasmid/Molecular Biology core, Protein core, vector core and assay development) within the Protein and Molecular Biology group.


Responsibilities will include:

Leadership of a team responsible for both executing R&D experiments across COMPANY’s programs, as well as core reagent production (Plasmids, antibodies, proteins, and vectors) to enable short and long-term success.

  • Support new preclinical discovery projects by working closely with scientists across the company to identify and execute key experiments.
  • Oversee the planning, execution, documentation, and interpretation of R&D experimental laboratory work, per program timelines.
  • Lead resource planning efforts needed to meet R&D objectives, including people, equipment, supplies, and space.
  • Collaborate with cross-functional peers and senior management to set objectives, gain alignment, communicate results, and project status, and meet company objectives.
  • Actively contribute to process improvements and the implementation of new technologies by being a subject matter expert in the field of molecular biology for external collaborations.



Preferred Qualifications

PhD in Molecular Biology/ Cell Biology or another similar field

  • At least 5-10 years of scientific leadership experience, ideally in the biotech industry
  • Expertise in molecular biology, protein engineering, IgG, and immunology.
  • Previous experience in the development of cell and gene therapies highly preferred.
  • Expertise in auto immune disease highly desirable.
  • Experience in a startup industrial setting highly desirable.
  • Strong leadership skills and a track record of achievement and communication demonstrated by patents, peer reviewed publications and presentations.
  • Strong organizational skills and an ability to operate cross-functionally in agile and collaborative environments.
  • Desire to be part of a growing organization that uses cutting-edge science.
  • A high level of flexibility to support various other activities and the ability to learn and guide the team in evaluating and developing new technologies outside of existing field of expertise.
  • Strong team orientation and passion for continuous self-development.
  • Experience in the biotech industry or in a startup industrial setting is preferred.

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