Associate Scientist, Analytica Development

2 months ago

Houston, United States Neurogene Inc. Full time

At Neurogene, we focus on bringing life-changing genetic medicines to patients and families affected by rare, devastating neurological diseases. Our clinical-stage company is developing NGN-401 for the treatment of Rett syndrome and NGN-101 for the treatment of CLN5 Batten disease. We are using our proprietary EXACT transgene regulation technology and internal expertise to develop novel approaches and treatments to address the limitations of conventional gene therapy in central nervous system disorders. Our wholly owned and fully operational GMP-capable manufacturing facility supports vector production from research through clinical grade and is designed for commercial-grade production. In addition, Neurogene is now trading on the NASDAQ Global Market. This transformative work is driven by our highly collaborative people and comes together to bring us closer to achieving our mission of turning devastating diseases into treatable conditions, to improve the lives of patients and their families. As an employee of Neurogene, you will be part of building a culture that honors patient and caregiver mindsets and nurtures innovation, creative problem solving and a strong sense of purpose.


Position Overview

Reporting into the Senior Scientist, Analytical Development, the Associate Scientist, Analytical Development plays a critical role in ensuring analytical work is executed consistent with product development timelines for Neurogene’s product pipeline. The candidate will perform routine sample testing according to standard operating procedures to support Process Development activities and process transfer to manufacturing. The selected candidate will have the ability to perform different laboratory techniques as well as superior written/oral communication skills, which are essential for success in this key role in a rapidly growing start-up. Furthermore, the candidate will be self-motivated and able to work both independently and within a collaborative team environment.


Accountabilities and Responsibilities

  • Assist molecular biology team to support Neurogene’s growing pipeline under the direction of the Senior Scientist
  • Perform routine assays for the characterization, in-process monitoring, and stability testing of Neurogene’s products in development. This will include, but is not limited to, ddPCR titer assays, qPCR assays for residual host cell or plasmid DNA, alkaline DNA gels, and other assays as required by the increasing regulatory requirements for gene therapy products.
  • Assist in the preparation and procurement of raw materials, consumables, inventory control as well as cleaning and waste disposal to support analytical development operations.
  • Maintain responsible laboratory protocols, data capture, lab notebooks, and/or computer detected records.
  • Interface with other departments (e.g., Process Development, Quality Control) to ensure alignment and support for analytical method development and process development activities.
  • Perform other duties as assigned.


Minimum Requirements

  • Education: BS in Molecular Biology, Biochemistry, Cell Biology, or related field.
  • Experience: Minimum 1 year of experience in academic lab setting or the biotech/pharmaceutical industry.
  • Knowledge: Basic understanding of bioprocessing, assay execution and troubleshooting are desirable.
  • Skills: Prior experience in ddPCR and/or qPCR is desirable.
  • Demonstrated strong ability in following and executing standard operating procedures, excellent interpersonal skills and the ability to prioritize multiple tasks.
  • A basic knowledge of Microsoft-based computer programs is required.
  • Ability to work both independently and collaboratively as part of a team in a fast-paced environment.
  • Excellent verbal and written communication skills.
  • Strong attention to detail with strong documentation and coordination practices.
  • Continuous strong focus on meeting or exceeding expectations in executing deliverables, performance and results.
  • Ability to track and measure performance against defined metrics.
  • Self-starter with high degree of energy, independence, initiative, and self-motivation, as illustrated by the ability to instill a sense of pace and urgency into the team.
  • Someone who moves fast and decisively in a balanced manner, with a passion for the growing company.
  • Passionate, collaborative, creative, willing to take prudent risks, and motivated by the creation of a company focused on transformative treatments for patients and their families.

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