Research Scientist

1 day ago

Lexington, United States Integration International Inc. Full time

Top three "Must Haves"

1. Lab experience in formulation of siRNA or oligonucleotides for systemic delivery

2. Hands on Analytical characterization of oligonucleotides

3. Experience in project management and collaborating with external CMO’s.


JOB DESCRIPTION

The Research Scientist RNAi formulations and Biophysics will be based in GNAT Research. The Research Scientist s a lab-based role with hands on formulation, biophysical and analytical characterization expertise of oligonucleotides for injectable delivery.


RELATIONSHIPS

Reports to Team manager/Senior Director of Nucleic acid Delivery, Formulations and Bioanalysis.

Interacts with peers who specialize in non-viral delivery manufacturing and characterization, Oligonucleotide chemistry and stability assays, PK and Bioanalysis of Oligonucleotides


ESSENTIAL FUNCTIONS

  • As a Sr Scientist I in the Nucleic Acid Delivery, Formulations & Bioanalysis overall department, you will become a part of a multinational and diverse team consisting of Research Associates, Specialist/Scientists. The goal of the team is to develop preclinical formulations of conjugated oligonucleotides apply advanced analytical characterization techniques and translate these to preclinical and clinical studies through internal and external collaborations in an automated high throughput manner.
  • Identifies gaps in technological capabilities provides recommendations to guide the research agenda
  • Manage multiple external collaborations for deliverables
  • Optimize long-term storage and stability conditions of RNAi conjugates and oligonucleotide formulations in general
  • Develop robust analytical methods and assays for QC and developability assessments
  • Communicate findings internally to team via presentations and written reports
  • Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines


QUALIFICATIONS

  • 3 years of relevant experience with a PHD (LEVEL II) or 3+ years of relevant experience with a Masters (LEVEL I)
  • Subject matter expertise in Pharmaceutical Sciences, oligonucleotide/peptide/antibody characterisation, or related scientific disciplines
  • In-depth and hands-on experience in a range of synthesis, characterization, and purification techniques, including but not limited to NMR, HPLC (analytical and preparative), Mass Spectrometry, IR, silica gel and reverse phase chromatography, TLC, recrystallization etc.
  • Acting as formulation subject matter expert for nucleic acid therapeutics.
  • Ability to establish screening assays for oligonucleotides in early discovery.
  • Experience with analytical method development for solubility, viscosity, degradation and rheological assessment for complex oligonucleotides
  • Experience with high-throughput screening methods such as DoE for optimizing formulations is a plus
  • Excellent verbal communication and interpersonal skills
  • Demonstrate awareness of external trends, influences, and advances in the landscape of RNA delivery and clinical translation
  • Experience with automation is considered an advantage
  • Proven track record in publishing in HQ/HI journals on relevant topics.

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