Senior Scientist, Biology Radiopharmaceuticals

2 months ago

Durham, United States Z-Alpha Therapeutics Full time

Z-Alpha Therapeutics is a pharmaceutical company dedicated to the discovery and development of radiotherapeutics targeting key biological pathways for solid tumors. The company has a revolutionary technology platform in the next generation of alpha particle therapy with potential to be a more targeted therapy, increasing efficacy and limiting toxicity compared to competitors in the radiotherapeutics space. The company has a world-class team of scientists with decades of experience and foundational intellectual property that enables the potential to bring multiple drug candidates into the clinic.


Job Summary


As a Senior Scientist in Biology with project management responsibilities, you will lead scientific initiatives and oversee project execution for Z-Alpha’s radiopharmaceutical programs. This role requires the ability to design experiments that support drug discovery and development. In addition to scientific leadership, you will manage cross-functional projects, ensuring alignment of research activities with overall program objectives and timelines.


Key Responsibilities:


Scientific Leadership: Conceptualize, design, and execute innovative functional assays for target validation and drug lead selection for radiopharmaceutical candidates.


Project Management: Lead and manage project workflows, coordinating activities across biology and chemistry teams. Ensure projects are completed on time and within scope.

Experimentation: Independently design and conduct cell-based and biochemical assays to generate high-quality, actionable data.


Analytical Development: Optimize and troubleshoot analytical assays, ensuring technical robustness and consistency with program needs.


Data Analysis & Reporting: Analyze complex datasets, interpret experimental outcomes, and present findings at project team and company-wide meetings.


Collaboration & Communication: Act as a liaison between cross-functional teams, external collaborators, and vendors to ensure smooth project execution.


Documentation: Maintain meticulous records of experiments, ensuring data integrity, reproducibility, and adherence to regulatory standards.


Mentorship: Provide scientific guidance and mentorship to junior team members, fostering a collaborative and innovative research environment.


Radiation Safety: Conduct radioligand assays in strict adherence to radiation safety protocols, ensuring a safe laboratory environment.


Required Qualifications:


  • Ph.D. in Biology, Oncology, or a related discipline with a strong focus on drug discovery.
  • 5+ years of experience in oncology or drug discovery within biotech or pharmaceutical research.
  • Extensive expertise in molecular and cell biology techniques including cell culture, flow cytometry, ELISA, western blotting, qPCR, and single-cell cloning.
  • Strong proficiency in project management tools, along with software like GraphPad Prism, FlowJo, Excel, and PowerPoint.
  • Highly organized, with strong time-management skills and the ability to adapt to rapidly changing project landscapes.
  • Collaborative team player with the ability to work independently and manage competing priorities effectively.
  • Excellent communication and leadership skills


Preferred Skills:


Experience in targeted radiotherapies, radiopharmaceutical development, or nuclear medicine.

Demonstrated success in leading cross-functional projects in a biotech or pharmaceutical setting.

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