Scientist / Sr. Scientist Cell Biology

4 months ago

Novato, United States XDemics Corporation Full time

Company Overview

Advanced cell and gene therapies remain expensive and hard to make, impeding powerful treatment options for patients across the spectrum of human disease. XDemics Corporation, a spin out from Caltech, tackles this challenge with a patented new technology that allows for production of cell and viral-based therapeutics in a natural and efficient way. We achieved this by separating the supply of oxygen and nutrients, creating the perfect environment for cells to thrive in a scalable, controllable and high-quality manner. We are seeking a talented and experienced Cell Biologist to join our dynamic team in our laboratory facilities on the beautiful campus of the world-famous Buck Institute in Marin County, California.


Position Summary

We are looking for an experienced and hands-on Scientist or Senior Scientist with expertise in cell biology, cell line engineering and Adeno-Associated Virus (AAV) production. The ideal candidate will have a strong background in molecular and cellular biology, with demonstrated experience in genetic engineering, tissue culture, and AAV vector production and characterization. This role will involve leading and executing experiments, developing novel cell lines, and optimizing AAV production processes.


Key Responsibilities

  • Perform cell culture maintenance, transfection, and selection of engineered cell lines.
  • Manipulation and expansion of primary cells.
  • Design, develop, and characterize genetically engineered cell lines for AAV production and other applications.
  • Optimize AAV production, purification, and characterization protocols to ensure high-quality and high-yield vector generation.
  • Conduct molecular biology techniques, including cloning, PCR, qPCR, and sequencing.
  • Analyze and interpret experimental data, maintaining accurate and detailed lab records.
  • Collaborate with cross-functional teams to support ongoing research projects and initiatives.
  • Troubleshoot and resolve technical issues related to cell line engineering and AAV manipulation.
  • Stay current with scientific literature and advancements in the field to implement best practices and innovative techniques.
  • Prepare technical reports, presentations, and publications to communicate research findings.


Qualifications

  • Ph.D. in Cell Biology, Immunology, or Molecular Biology, or a related field with 3+ years of relevant postdoctoral or industry experience; or M.Sc. with 5+ years of relevant experience.
  • Extensive hands-on experience in gene editing, including transposons, CRISPR, or other technologies.
  • Proven expertise in the manipulation and production of AAV vectors.
  • Proficiency in cell culture techniques, including expansion and manipulation of primary mammalian cells
  • Strong molecular biology skills, including cloning, PCR, qPCR, and sequencing.
  • Excellent analytical and problem-solving skills with the ability to troubleshoot complex experimental issues.
  • Strong organizational and documentation skills, with attention to detail.
  • Ability to work independently as well as collaboratively within a team environment.
  • Excellent communication skills, both written and verbal.


Preferred Additional Qualifications

  • Experience with stem cell or primary human immune cell manipulation and expansion/
  • Experience with large-scale AAV production and purification.
  • Development experience for cell gene therapy products.
  • Knowledge of regulatory requirements and guidelines for cell gene therapy products.
  • Previous experience in a biotech or pharmaceutical industry setting is a plus.
  • Familiarity with bioinformatics tools and data analysis software.


What We Offer

  • Competitive salary and elite benefits package.
  • Opportunity to work in a fast-paced, innovative environment with a team of dedicated professionals.
  • Career growth and development opportunities within a rapidly expanding company.
  • Access to state-of-the-art facilities and resources.


Equal Opportunity Employer

XDemics is an equal opportunity employer and is committed to creating an inclusive environment for all employees.


Benefits

We offer our employees competitive compensation and elite benefits, including paid time off, health, vision and dental insurance, disability insurance, flexible spending accounts, a 401(k) plan (plus match), and participation in the company’s stock option plan.

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