Associate Researcher I-Center for Disease Neurogenomics Roussos lab

2 weeks ago

New York, New York, United States Mount Sinai Health System Full time
Job Description

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

Roles & Responsibilities:

The Center for Disease Neurogenomics (CDN) Roussos lab at the Icahn School of Medicine at Mount Sinai (ISMMS) is seeking a talented, self-motivated individual with experience in histology, and molecular biology to participate in cutting edge spatial omics research.

We are inviting applications for an Associate Researcher I position to study neuropsychiatric and neurodegenerative disorders using state-of-the-art spatial multiomics tools. The lab currently employs a range of spatial omics approaches, including Curio Seeker and the 10x Genomics Visium and Xenium platforms. We seek candidates with experience in neuroscience, histology, and molecular biology. The successful candidate will prepare human brain specimens for spatial transcriptomic and single cell sequencing. Previous experience in neuroscience, cryosectioning, immunofluorescence, image acquisition and basic image analysis is desirable.

The CDN provides a hub for neurogenomics and disease biology, with a specific focus on developing and enhancing precision medicine across neuropsychiatric and neurodegenerative disorders. The successful candidate will join a highly productive team of scientists with extensive expertise across a broad range of disciplines, including genetics, genomics, neuroscience and clinical psychiatry. The CDN promotes collaboration, inclusion, and cross-disciplinary interactions between basic wet lab and dry lab scientists and clinicians, and provides strong support to junior scientists.

Details of Research Project:

Generating high resolution maps of the gene expression patterns in specific cell-types and regions of the human brain is an important step towards understanding the molecular basis of neuropsychiatric and neurodegenerative disorders. In our research projects, we utilize human brain samples from controls and individuals affected by a number of disorders, including schizophrenia, bipolar disorder and Alzheimer's disease. Tissue specimens from disease relevant brain regions are sectioned and prepared for a range of experimental approaches, including histology, immunofluorescence, spatial transcriptomic, single cell multiomics and proteomics studies. In depth computational analyses of these complementary datasets provides a detailed view of how gene expression influences brain function and contributes to disease.

Responsibilities
  • Dissecting and freezing brain tissues with established protocols.
  • Cryosectioning of brain specimens at various, assay specific, thickness.
  • Carrying out Nissl and H&E staining using established protocols, followed by imaging.
  • Carrying out Immunofluorescent staining with established protocols, followed by imaging.
  • Preparing samples for the 10x Genomics Xenium spatial transcriptomic platform, as well other for omics experiments using established protocols.
Goals/Outcomes of the Research Project:

Our goal is to establish a unified single-cell and spatial brain atlas that incorporates molecular, anatomical, and functional annotations of cell types throughout the human lifespan and in certain disease contexts. The atlas will combine high-resolution single-cell and a spatially-resolved brain atlas at population scale, establishing a framework facilitating both fundamental neuroscience investigations and disease focused research.

Qualifications
  • Bachelors or Masters degree in science or related field required neuroscience, histology and molecular biology preferred
  • 1 - 2 years of research/laboratory experience
About Us

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai's unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:
  • Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.
  • Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.
  • Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.
At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.

Explore more about this opportunity and how you can help us write a new chapter in our history

"About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism."

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