Senior Manager, Vivarium and Research Operations
1 month ago
Denali Therapeutics is a biotechnology company based in South San Francisco, California that is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development.
Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
The OpportunityWe are currently seeking an outstanding Senior Manager of Vivarium and Research Operations to join our Preclinical Translational Sciences group.
The primary function of this group is to leverage the use of animal models for biomarker discovery as well as establishing PK/PD relationships with Denali's therapeutic candidates.
The role will be critical in supporting preclinical work in Discovery and Development by providing direct oversight and supervision of activities in the animal research facility in addition to help in resourcing and execution of in vivo study activities, as needed.
Responsibilities (included but not limited to the following):
Approximately 70% of the timeServe as the expert and primary point of contact to respond to questions and concerns raised by researchers related to the care, use, health, and welfare of mice/rats and leverage basic knowledge and understanding of clinical observations and treatment methods to provide veterinary advice and care as neededInteract with scientists to understand their in vivo research needs, engaging them in a flexible and constructive manner to address matters of ethical review with a focus on 3Rs, humane endpoints, and avoidance of adverse effectsTrain research staff on various components of proper animal use including preparation of animals for surgery, anesthesia, surgical techniques, post-operative monitoring, injections, and sample collectionConduct orientation, safety and animal welfare training for vivarium usersEnsure that in vivo study applications are performed in accordance with defined protocols and assist in the development, modification, and review of procedures and protocols, as neededReview/approve health reports for animal shipments coming in from non-approved vendorsServe as a voting member of the IACUC committee, participate and ensure readiness for IACUC inspections and meetings, and assist in other veterinary related IACUC activitiesManage site DEA activities and processesOversee procurement processes by helping to order supplies and equipment to sustain day-to-day operations of the animal facilityAbility to interact cross-functionally with scientists, external vendors, IACUC, facilities, EH&S and management to problem solve and improve processes, as neededResponsibilities may require a work schedule that may include working outside of normal hours to provide assistance to queries and concerns in the animal facilityApproximately 30% of the timeAbility to assist with in vivo study activities as needed across therapeutic programs which includes drug dosing in mice and rats by various routes of administration (IV, PO, IP, SQ, RO, IT), in life sample collections (i.e.
blood collection via submental, tail vein, jugular, saphenous, etc.and urine collection) and necropsy procedures including terminal blood collection by cardiac puncture, perfusion of rodents and gross anatomical tissue harvestingFamiliarity with genetically engineered rodent disease models and breeding colony managementAbility to think creatively about ways to leverage novel techniques or tools for in vivo useMaintain accurate and complete laboratory records in a timely mannerResponsibilities require a work schedule that may include working outside of normal work hours, to meet business demands such as weekends/Holidays to support dosing (on a rotating schedule) RequirementsBS/MS in Biology/Neuroscience/related field or equivalent in college / diploma credits and work experience combinedMinimum 5 years experience of direct oversight and supervision of vivarium operationsPrior management and leadership skills with the ability to successfully motivate, teach, and lead a team, fostering a collaborative and cohesive cultureExtensive hands-on experience working with both mice and ratsMust have strong work ethic, proficiency in animal welfare and overall knowledge for animal care and use, and skills to maintain a high-quality animal care programIndependent, highly organized, great attention to detail, ability to multitask, and a strong desire to work in a highly collaborative and fast paced environmentExcellent interpersonal and communication skillsExperience with computer applications such as MS Excel, MS Word, MS PowerPointDenali is committed to its core company value of unity by creating a diverse and inclusive environment.
We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
Salary Range:
$152,000 to $182,667. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at *This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.
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