Scientist II, Chemistry
3 weeks ago
Who We Are:
ReCode Therapeutics is a clinical-stage genetic medicines company using precision delivery to power the next wave of mRNA and gene correction therapeutics. ReCode’s proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues and cells implicated in disease, enabling improved efficacy and potency. ReCode’s lead programs include RCT1100 for the treatment of primary ciliary dyskinesia caused by pathogenic mutations in the DNAI1 gene, and RCT2100 for the treatment of the 10-13% of cystic fibrosis patients who have Class I mutations in the CFTR gene and do not respond to currently approved CFTR modulators. RCT1100 and RCT2100 are inhaled disease-modifying mRNA-based therapies formulated using the SORT LNP delivery platform. ReCode is expanding its pipeline to develop potential therapies for other rare and common genetic diseases, including musculoskeletal, central nervous system, liver and infectious disease indications.
Summary of Position:
We are seeking a highly motivated Chemist to expand our next-generation SORT LNP platform. This is an outstanding opportunity for a well-rounded chemistry generalist with a keen scientific aptitude and curiosity coupled with passion for using chemistry to tackle the broadest variety of synthetic challenges to advance our non-viral delivery technology. The successful candidate will be an integral part of enabling targeting of lipid-nanoparticles in support of ReCode’s next generation in vivo delivery platform.
Responsibilities:
Design, synthesize, and purify novel chemical compounds including, but not limited to- lipids, polymers, or bioconjugates with minimal supervision Work closely with analytical and formulation scientists to characterize and evaluate compounds for delivery systems Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing guidance and troubleshooting where appropriate Manage one or more direct reports; hire and mentor additions to the team Contribute to novel LNP discovery and formulation, process development, and optimization for in vivo delivery of mRNA, siRNA, gene therapy, and other therapeutic modalitiesQualifications:
PhD in Chemistry, medicinal chemistry, chemical or bioengineering, or a related field and 3+ years experience in the biotech/pharma industry. Prior experience in lipid chemistry or conjugation chemistries for drug delivery. Knowledge of NMR, MS, HPLC, TLC, and other common analytical methods Excellent project leadership skills in driving for results and innovation; ability to execute within a matrixed organization Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities Highly collaborative, team-oriented, and considerate of the needs of others Desire to work in a fast-paced environment and contribute to developing the next generation of lipid nanoparticlesSalary Range: 130-135K
Benefits Offered for Full-Time Employees:
No premium cost for employees - 100% subsidized by ReCode for full-time employees Company 401k contribution 15 days of company paid holidays, including a holiday shutdown (usually the last week of the year) Mental health support for employees & their families FSA available, including a lifestyle spending account subsidized by company Employee discounts at hotspotsReCode Therapeutics (www.recodetx.com) offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.
ReCode Therapeutics is an Equal Opportunity Employer.
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