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Postdoctoral Fellow, 3Rs Innovation
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At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at
areer advice from mentors while building a network of professional contacts and developing the skills needed to advance their careers.
Preclinical Sciences and Translational Safety (PSTS) division of J&J Innovative Medicine R&D is an integrated end to end organization encompassing bioanalysis, drug disposition and metabolism, in vivo sciences (IVS), investigative toxicology, pathology, science operations and data sciences, and toxicology, with a focus on understanding the disposition and potential risks of candidate therapeutics across all therapeutic areas and modalities, and covering the entire portfolio. This postdoctoral research will be carried out in the IVS group with collaborations across the PSTS division.
IVS is responsible for the oversight of all internal and external in vivo activities across the JNJ Innovative Medicine R&D portfolios with a focus on the core disciplines of Animal Welfare & Regulatory Compliance, External Engagement & 3Rs Innovation, In Vivo Models & Scientific Collaborations, Veterinary Care, In Vivo Training, and Vivarium Operations & Management.
J&J Innovative Medicine R&D Discovery is seeking a talented and innovative Postdoctoral Fellow 3R's (Reduction, Refinement, and Replacement) with extensive knowledge and expertise in the area of humanized mouse model development, and an interest in applying their knowledge to the pursuit of research in support of the 3Rs. In particular, the successful candidate will identify the leading mouse strains for the humanization of the immune system, optimize methods for humanization of the mouse immune system, and investigate the use of the humanized mouse immune system models as improved predictors of the immunotoxicity of biologics. The successful completion of this project is expected to provide more predictive preclinical models for use in safety and toxicity, as well as efficacy. Better predictive models for use in drug discovery and development will reduce the total number of animals used in the preclinical safety and toxicology assessment phase of the development of biologics, including reducing the use of higher species, in addition to supporting earlier attrition and reduced safety complication in the clinic.
The Postdoctoral Fellow will collaborate closely with IVS experts of in vivo model development , and with colleagues across PSTS to support the characterization of the functionality of the immune system across the different models established, and to assess the functionality of the models in a retrospective study of their ability to predict safety and toxicology impacts across a panel of therapeutic agents.
Qualifications
- PhD degree received in the past 0-3 years or by the start of the position
- Humanized mouse immune system models experience required
- Experience with cell biology, immunology, and flow cytometry
- Microsoft Office and statistical software such as GraphPad Prism
- Strong communication and presentation skills
- Ability to work on-site in La Jolla, CA with 15% travel as needed
- Permanently authorized to work in the U.S. and must not require sponsorship at the time of hire or in the future
The anticipated base pay for this position is $109,500 but will be based on candidate's program year, discipline, degree and/or experience. This position is eligible for a sign-on and/or early incentive bonus. This is a two year duration based role that has eligibility for severance.
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis.
Benefits:
- Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
- Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).
- This position is eligible to participate in the Company's long-term incentive program.
- Employees are eligible for the following time off benefits:
- Vacation - up to 120 hours per calendar year
- Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year
- Holiday pay, including Floating Holidays - up to 13 days per calendar year
- Work, Personal and Family Time - up to 40 hours per calendar year
For additional general information on Company benefits, please go to: -
This job posting is anticipated to close on May 13th, 2024. The Company may however extend this time-period, in which case the posting will remain available on to accept additional applications.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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