Associate Scientist, Analytical Development
3 weeks ago
Why Join Intellia?
Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.
We wantall ofour people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.
How you will Achieve More with Intellia:
As an Associate Scientist of NGS, you will join the Analytical Development team within the Technical Operations group and embrace the opportunity to transform amazing sciences and technologies to powerful cures. As an Associate Scientist within the analytical development department, you will employ your strong molecular biology skills focused on broad sequencing (NGS) and nucleic acid quantification space. Responsibilities also include:
- The successful candidate will independently run and optimize existing NGS workflows such as target amplicon sequencing based assays and genome editing off-target analysis.
- Design, execute and troubleshoot experiments to optimize assay performances and ensure assay robustness
- Extensive experience with molecular biology techniques such as DNA purification, RNA Extraction, PCRs, NGS library preparation and quantification.
- Work with R&D team on development and validation of new NGS and other molecular based assays.
- Coordinate with external CROs or vendors on method development, qualifications, and validations; review and approve SOPs and reports.
- Work both independently and as part of a collaborative team to design, plan and execute experiments that support development activities, project goals, and platform development
- Meet established timelines, maintain accurate records of development work and testing in a GMP environment utilizing electronic notebook solutions
- Present data within group and at department meetings.
About you:
Are you interested in working in the analytical development group? If you say yes, we encourage you to apply Other qualifications and desired skills include:
- B.S with 5+ or MS with 3+ years of experience in a relevant field required (Molecular Biology, Biochemistry, Biotechnology or Chemical Engineering or related areas)
- Ideal candidate should have strong understanding of NGS fundamentals and applications, critical factors influencing data quality, and an ability to troubleshoot the sequencing process end to end.
- Prior experience in NGS (Illumina based) assay and reagent development, troubleshooting and optimization with hands-on experience with nucleic acid extraction, library preparation and NGS sequencing.
- Strong knowledge in molecular biology assays such as qPCR, ddPCR, RT-PCR and nucleic acid-based assays is required.
- Ensure timely data delivery, working with automation and informatics teams to promptly address run failures, and work with collaborators to communicate updates and troubleshoot experiments.
- Good understanding of statistical tools for data analysis is strong plus.
- Must be able generate SOPs and technical reports with appropriate level of detail, as well as perform bioassay assay trending.
- Experience managing CROs.
- Knowledge of FDA, cGMP, and ICH regulatory requirements in the context of bioassay/potency assay development and qualification is desired.
- Excellent organizational, documentation, and communication skills; adaptive learning, critical thinking, and the ability to work well in a team.
Meet your future team:
The Analytical Development team is a group of energetic, brilliant, fun and motivated individuals. We work on different modalities and still work as a team to achieve our goals. We are a small but growing family. This group is responsible for developing robust and innovative analytical methods to support internal and external manufacturing processes. We support Intellia’s clinical programs as well as in vivo and ex vivo emerging pipelines. While much of the day-to-day operations require wet-lab work, our team focus is not only on building everyone’s technical expertise but also on fostering an environment for career growth as scientists and engineers in the biopharmaceutical industry. You will report to the Senior Scientist, Analytical Development. He loves to see people grow and develop and look forward to learning from your experiences and building the team together with you.
Covid-19 Vaccination Policy:All Intellia employees, regardless of work location, are expected to follow all applicable federal, state, and local public health regulations and guidelines, and are strongly encouraged to follow all public health recommendations, including being vaccinated for COVID-19.
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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