Research Associate III, Targeted Techniques, CGR

4 weeks ago

Derwood, United States Frederick National Laboratory for Cancer Research Full time
Research Associate III, Targeted Techniques, CGR

Job ID: req3959
Employee Type: exempt full-time
Division: Clinical Research Program
Facility: Rockville: 9615 MedCtrDr
Location: 9615 Medical Center Drive, Rockville, MD 20850 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION

The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of the NCI's Division of Cancer Epidemiology and Genetics (DCEG), the world's most comprehensive cancer epidemiology research group. CGR is located at the NCI-Shady Grove campus in Rockville, MD and operated by Leidos Biomedical Research, Inc. We care deeply about discovering the genetic and environmental determinants of cancer, and new approaches to cancer prevention, through our contributions to the molecular, genetic, and epidemiologic research of the 70+ investigators in DCEG. Working in concert with epidemiologists, biostatisticians, and basic research scientists in DCEG's intramural research program, CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. This includes the design and analysis of high throughput studies using various types of "-omics" technologies such as array- and sequence-based genome-wide association studies, studies of tumor characteristics using integrated genomic data analysis, and molecular epidemiologic studies based on novel assays focused on the metabolome and microbiome. We are seeking a research associate to join our team to support a wide range of genotyping and next-generation sequencing assays.

KEY ROLES/RESPONSIBILITIES

Within CGR, the Genomics Laboratory is a fast-paced, high throughput genotyping and sequencing facility dedicated to the support of genetic and epidemiologic studies for investigators at the National Cancer Institute. We are recruiting for a Research Associate III position within the Genomics Laboratory to work as part of a team performing a variety of Next Generation Sequencing (NGS), genotyping, and gene expression experiments.

Key responsibilities for the successful candidate will include:
Perform NGS experiments on long-read and short-read sequencers Perform genotyping and gene expression experiments Meet expected schedules and performance expectations in a fast-paced research laboratory environment Utilize good laboratory practices and molecular biology expertise to ensure that highly sensitive assays are performed successfully Follow established protocols and assist with deviations and corrective actions Routine maintenance, operation and troubleshooting of laboratory equipment used Support a culture of continuous improvement and accountability Contribute to troubleshooting of issues associated with assay processing Contribute to planning and execution of process improvement, assay development, and optimization experiments Ensure proper documentation of experimental parameters and results for all laboratory processes. Participate in the writing and review of laboratory SOPs Train and mentor laboratory staff Work collaboratively within and across teams in CGR (project management, LIMS support, technology development, quality assurance, bioinformatics) to successfully move projects forward or help integrate new approaches into routine use
BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
Possession of Bachelor's degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or four (4) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency In addition to the education requirement, a minimum of eight (8) years of related biomedical experience Expertise in performing, troubleshooting, or optimization of NGS or other molecular biology assays Ability to design sound experiments, collect and interpret results independently Strong understanding of molecular biology Careful attention to detail Critical thinking skills and ability to identify important variables in an experiment Collaborative, team-oriented approach to solving problems and achieving goals Strong organization skills, ability to multitask and manage time effectively Excellent communication skills (verbal and written) Working knowledge of Windows-based computer operating systems and Microsoft Office suite Ability to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:
Experience with Illumina, Ion Torrent, and/or PacBio sequencing technology and instrumentation Experience using high-throughput laboratory equipment, such as automated liquid handlers Familiarity with LIMS systems for sample and workflow tracking Expertise with a wide range of specimen types and analytes used in genomics, including DNA, RNA, and FFPE-derived analytes
JOB HAZARDS
This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations
Commitment to Diversity
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

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