Vice President, Neuroscience Pharmacology and Translational Biomarkers

Found in: beBee S US - 1 week ago

New Haven, United States Arvinas Inc. Full time

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs: ARV-766 and bavdegalutamide for the treatment of men with metastatic castration-resistant prostate cancer; and vepdegestrant (ARV-471) for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer. Arvinas, as part of its overall business strategy, selectively assesses opportunities for potential collaboration, license, marketing and royalty arrangements, and similar transactions, to advance and accelerate the development and enhance the commercial potential of its product candidates.

#TeamArvinas is made up of approximately 450 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.

For more information, please visit www.arvinas.com. 

 

Position Summary

The Vice President  of Neuroscience Pharmacology and Translational Biomarkers is responsible for enterprise leadership of  all aspects of driving the neuroscience portfolio. This includes managing exploratory new target selection, generation of in vitro and in vivo data used to develop pharmacokinetic / pharmacodynamic relationships, and the identification of translational biomarkers to support lead optimization and clinical development of PROTAC degrader molecules for severe neurologic disorders. 

This position reports to SVP of Neuroscience and Platform Biology and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

Defines, revises and champions asset discovery and development strategies while implementing plans to support prioritization and expeditious progression of the neuroscience portfolio. Builds, leads and inspires a high-performing team through mentorship and development of leadership, scientific and technical capabilities. Enables team to make critical choices in identifying and developing appropriate preclinical in vivo models to support lead identification and optimization based on a deep understanding of disease and target biology, downstream pathways, and target-dependent functional endpoints. Guides team of scientists to build high-quality reliable ex vivo target engagement assays, pathway biology assays, and disease biomarker assays to support preclinical pharmacology studies. Contributes to the design and data analysis strategy of preclinical pharmacology studies to characterize compound activity and establish pharmacokinetic and pharmacodynamic relationships to drive compound optimization and inform human dose projections. Owns and develops the early clinical biomarker strategy across the neuroscience portfolio. Manages the team to develop and execute high quality robust qualified assays to quantify translational biomarkers for targets for tauopathies, Parkinson’s Disease, Huntington’s disease, and other neurodegenerative diseases. Identifies and manages collaborations with contract research organizations and academic labs for the transfer of translational biomarker assays, method development, validation, and clinical execution. Serves as key contributor to preclinical study reports and documents to support Regulatory (IND/ CTA) filings, Investigator Brochures, and clinical study protocols and lab manuals. Works effectively with cross-functional program and development teams to lead programs and strategically progress the pipeline (this includes Go/ No Go decisions based on quality data from in vivo pharmacology or biomarker-based studies) Mentors leaders, develops staff, and promotes culture of collaboration and teamwork.

Qualifications

Established scientific reputation with strong knowledge of statistics in the assessment of disease-relevant in vivo models and biomarker endpoints to support neurodegeneration research and development efforts as evidenced by strong publication record, and relationships with key opinion leaders.  Strong leadership experience in initiating xternal science, collaborations, and relationships with academic research teams, CROs, and patient advocacy groups.  Demonstrated expertise in, and leader of a team responsible for, in vivo pharmacology in preclinical models and translational human biomarkers using clinical samples.   Examples of contributions to exploratory neuroscience target selection and demonstrated ability to use in vitro pharmacology data to drive program decisions and portfolio build.  Clear track record of authoring relevant sections of IND/ CTA documents and contributions to clinical protocol design.  Demonstrated ability to lead directly and cross-functionally; recruit, mentor, develop, and motivate a team of creative, experienced scientists to deliver program / portfolio decisions.  Communicates effectively with leadership, employees, colleagues, leadership teams, and the broader external neuroscience community as evidenced by publications, presentations, inventions, and contributions to regulatory filings for clinical candidates.  Confident self-starter with a strong work ethic, who holds self and others accountable in the context of greater portfolio deliverables. 

Education 

Ph.D., with 15+ years of industry/ biotech leadership experience in neurobiology and pharmacology with clear contributions to clinical candidates.

 

#LI-New Haven, CT

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity Employer   

  • Vice President, Neuroscience Pharmacology and Translational Biomarkers

    Found in: beBee jobs US - 1 week ago

    New Haven, Connecticut, United States Arvinas Inc. Full time

    Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting...

  • Executive Director, Neuroscience Pharmacology and Translational Biomarkers

    Found in: beBee jobs US - 2 weeks ago

    New Haven, Connecticut, United States Arvinas Inc. Full time

    Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting...

  • Senior/Principal Scientist, Translational Sciences

    Found in: beBee jobs US - 4 days ago

    New Bedford, Massachusetts, United States PharmaEssentia U.S.A. Full time

    Senior/Principal Scientist, Translational SciencesJob summary: PharmaEssentia Innovation Research Center (PIRC) is seeking a highly motivated and experienced senior or principal scientist to join our Translational Sciences team and contribute to the development of first-in-class and best-in-class biotherapeutics, including cytokines, antibodies, and...

  • Vice President Finance

    Found in: Appcast Linkedin GBL C2 - 1 week ago

    New Haven, United States The Bolton Group Full time

    The Bolton Group is engaged with a $1b+ PE-backed global manufacturer to hire a Vice President of Finance. This position will report to the CFO and manage a global corporate finance team. This hire will also be the point-person for communications and deliverables with the PE deal team.Vice President/Head of FP&A – Qualifications10+ years of progressive...

  • Vice President Finance

    1 week ago

    New Haven, United States The Bolton Group Full time

    The Bolton Group is engaged with a $1b+ PE-backed global manufacturer to hire a Vice President of Finance. This position will report to the CFO and manage a global corporate finance team. This hire will also be the point-person for communications and deliverables with the PE deal team.Vice President/Head of FP&A – Qualifications10+ years of progressive...

  • Vice President Finance

    Found in: Appcast Linkedin GBL C2 - 6 hours ago

    New Orleans, United States Urban League Of Louisiana Full time

    The Urban League of Louisiana (ULLA) is seeking a Vice President of Finance to lead all financial and fiscal management aspects of the organization’s operations. The Vice President of Finance plays a key role in helping shape and deliver on the strategic imperatives of ULLA. Reporting to the President/CEO, this individual is a member of an eight-person...

  • Vice President Finance

    15 hours ago

    New Orleans, United States Urban League Of Louisiana Full time

    The Urban League of Louisiana (ULLA) is seeking a Vice President of Finance to lead all financial and fiscal management aspects of the organization’s operations. The Vice President of Finance plays a key role in helping shape and deliver on the strategic imperatives of ULLA. Reporting to the President/CEO, this individual is a member of an eight-person...

  • Professor/Chair, Department of Neuroscience

    Found in: beBee jobs US - 2 weeks ago

    New York, New York, United States Columbia University Department of Neuroscience Full time

    Columbia University Vagelos College of Physicians and Surgeons is seeking a new Chair of its Department of Neuroscience. The Department is composed of 27 faculty members with primary appointments in the Department of Neuroscience and of 21 faculty members with secondary appointments in the department. Primary departmental faculty members are also principal...

  • Vice President

    Found in: beBee jobs US - 2 weeks ago

    New York, New York, United States Santander Full time

    Vice President - Leveraged Finance Credit Risk OfficerThe Leveraged Finance Credit Risk Officer - Vice President, reviews credit applications submitted by the front office to prepare executive summaries for the management of the Credit Department.Scope of the analysis and review includes, but not limited, to quantitative and qualitative analysis of the...

  • Professor/Chair, Department of Neuroscience

    Found in: beBee S US - 1 week ago

    New York City, United States Columbia University Department of Neuroscience Full time

    Columbia University Vagelos College of Physicians and Surgeons is seeking a new Chair of its Department of Neuroscience.  The Department is composed of 27 faculty members with primary appointments in the Department of Neuroscience and of 21 faculty members with secondary appointments in the department. Primary departmental faculty members are also...

  • Vice President of STEM

    Found in: Resume Library US A2 - 1 week ago

    New York County, New York, United States KIPP Foundation Full time

    Job Description About The Position  The Vice President of STEM leads the K-12 math and science vision for all KIPP schools and oversees the Math and Science Teams. Additionally, the Vice President of STEM collaborates with the Teaching and Learning Leadership team, including the Vice President of Literacy and Humanities, Vice President of School Support,...

  • Vice President of Construction

    1 week ago

    New Orleans, United States CareerBuilder Full time

    Vice President of Construction About the Company Influential group of museums & parks dedicated to the natural environment Industry Museums and Institutions Type Non Profit Founded 1924 Employees 501-1000 Categories Renewables & Environment Forestry Environmental Consulting Nature Conservation Museums Zoos Education Non-Profit & Philanthropy Entertainment &...

  • Vice President of Engineering

    1 week ago

    New York, United States GreenBridge Energy Full time

    GreenBridge Energy are partnered with an extremely influential utility scale battery energy storage business, currently in hyper-growth phase! Title: Vice President of EngineeringOur customer is a pioneering leader in the development of cutting-edge battery technologies. Their commitment to innovation and safety has positioned them at the forefront of the...

  • Vice President of Business Development

    Found in: beBee jobs US - 2 weeks ago

    New York, New York, United States Hammes Full time

    Our capabilities include real estate strategy and planning, project management, development, investment and property management for healthcare clients and other leading institutions.Hammes is consistently ranked as one of the nation's top healthcare developers by both Modern Healthcare's Construction & Design Survey and Revista's Outpatient Healthcare Real...

  • Vice President

    Found in: Jooble US O C2 - 21 hours ago

    New York, NY, United States Goldman Sachs & Co. LLC Full time

    Vice President with Goldman Sachs & Co. LLC in New York, New York. Develop profitability and scalability models to assess and implement new business opportunities across all multi-asset solutions (MAS) business channels. Lead financial analysis, including global and regional growth projections by fa...

  • Vice President of Finance

    8 hours ago

    New Orleans, United States Professionally Polished Full time

    Job DescriptionJob DescriptionBecome a Leader of Our Team at Urban League of Louisiana (ULLA)!Position: Vice President of Finance Are you an experienced financial leader driven by strategic fiscal management and operational excellence? The Urban League of Louisiana seeks a Vice President of Finance like you! With a longstanding commitment to economic equity...

  • Vice President Student Affairs

    Found in: Talent US A C2 - 1 week ago

    New Orleans, United States InsideHigherEd Full time

    Vice President Student AffairsPresident Direct ReportsLocation: New Orleans, LASummaryTulane University, one of the nation’s most prestigious research institutions, invites nominations and applications for their next Vice President of Student Affairs (VPSA). Working closely with the Tulane community, especially students, the Vice President will lead the...

  • Vice President

    Found in: beBee jobs US - 1 week ago

    New York, New York, United States Bank of America Full time

    Job Description:At Bank of America, we are guided by a common purpose to help make financial lives better through the power of every connection. Responsible Growth is how we run our company and how we deliver for our clients, teammates, communities and shareholders every day.One of the keys to driving Responsible Growth is being a great place to work for our...

  • Vice President for Strategic Communications

    1 week ago

    New York, United States Barnard College Full time

    If you are a current Barnard College employee, please use the internal career site to apply for this position. Job: Vice President for Strategic Communications Job Summary: Barnard College is among the most selective academic institutions in the nation, providing the highest-quality liberal arts education to promising and high-achieving young women. Barnard...

  • Assistant Professor

    Found in: beBee S US - 1 week ago

    New York, United States State University of New York Health Sciences University - Department of Physiology And Pharmacology Full time

    The State University of New York (SUNY) Downstate Health Sciences University (Downstate) invites applications for a tenure-track faculty position at the rank of Assistant Professor to lead a laboratory research program in one or more field of cognitive neuroscience, preferably involving learning and memory.Research projects may be at the molecular/cellular,...