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Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
What You will Achieve
We are seeking a highly motivated chemical engineer for the role of Senior Scientist -Chemical Engineer for API Process Development within Chemical Research and Development (CRD) in Groton , CT . You will join a diverse team responsible for developing A ctive P harmaceutical I ngredients (API) processes for use at manufacturing plants across Pfizer's network. Chemical engineering principles contribute to the successful development , optimization and scale up of API manufacturing processes. You will design and perform engineering-related laboratory experiments , in combination with process simulation and statistics. Strong communication , high technical aptitude, and creativity to foster original ideas are required for success in this position.
CRD, as part of Pfizer R&D in Pharmaceutical Sciences, is responsible for the development of process technology to manufacture active pharmaceutical ingredients (API). CRD scientists engage in all facets of development from small-scale synthesis in support of medicinal chemistry programs, to the development of the commercial synthetic route. In collaboration with chemists and analysts, y ou will lead the engineering activities during process development, process scale up, and technology transfer to our clinical and commercial manufacturing sites and external facilities. Given the dynamic team environment and fast-paced project timelines, strong interpersonal and communication skills are essential. This laboratory-based position offers the opportunity for cross-training and innovation of new technologies and processes .
How You Will Achieve It
Apply chemical engineering principles to design and perform experimen ts using modern laboratory instrumentation to develop robust unit operations and increase process understanding.
A ssess scalability and robustness for API processes with understanding of large-scale manufacturing equipment , capabilities, and operations .
Select, develop, and apply new process technologies (batch, semi - batch, and continuous flow) to facilitate process design to achieve project goals.
Support technology transfer of processes to internal clinical and commercial API manufacturing facilities and external suppliers. May spend time at the commercial launch site supporting process validation activities .
App ly process simulation tools and statistic al packages to understand the kinetic and thermodynamic factors impacting various unit operations, such as reaction , extraction, distillation, crystallization, filtration, and drying.
Prepare internal research reports and technical presentations summarizing API process development activities to capture process knowledge and transfer process understanding to Pfizer's commercial manufacturing .
Champion the development of novel laboratory instrumentation and computational tools to increase knowledge capture and process understanding. Support the development and implementation of new and existing workflows and methodologies.
Remain current with the process engineering and chemistry literature. May collaborate and author external publications and present research at external conferences.
Contribute s to the preparation of the Chemistry and Manufacturing Controls (CMC) section of the New Drug Application (NDA).Participate in data verification, PAI preparedness, and post submission query response.
Qualifications
Must-Have
MS in Chemical Engineering with 5+ years of experience or PhD in Chemical Engineering with 0-3 years of relevant experience
Excellent knowledge of chemistry and chemical engineering principles and sound understanding of applied reaction kinetics, reactor design, chemical thermodynamics, heat and mass transport, engineering statistics, and process modeling
Outstanding laboratory skills , attention to detail, and ability to solve technical problems
Exceptional interpersonal, multi-disciplinary team collaboration, and communication skills
Nice-to-Have
Working knowledge of reaction modeling, property prediction, and process simulation tools including: Aspen, gPROMS , DynoChem , VisiMix , and COSMOtherm
A good foundational understanding of organic chemistry
Demonstrated laboratory and computational experience in reaction engineering topics
Working k nowledge of c rystallization development
Working k nowledge of Design of Experiment ( D O E ) studies and statistical analysis
Working knowledge of analytical techniques such as HPLC/UPLC, MS, PXRD, DSC, TGA, and NMR
Working knowledge of application of in-situ analysis tools to process understanding including: FTIR, Raman, FBRM, UV/Vis
Computational fluid dynamics (CFD) expertise in M-Star or Fluent
P rograming experience , including Python and/or Matlab
Applied data science methods , such as machine learning and AI
Experience in automating laboratory equipment and processes including use of LabView
Work Location Assignment:On Premise
Relocation support available
The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
