Associate Research Fellow
3 weeks ago
The successful candidate will join the Translational Modeling and Simulation (TMS) team within Pfizer's Department of Pharmacokinetics, Dynamics, and Metabolism (PDM). As a core member of multidisciplinary project teams, the candidate will leverage principles and practices of quantitative translational pharmacology (PKPD, PBPK, QSP) to influence decision making from project ideation through early clinical development for both biologic and small molecule modalities. Management and mentorship of junior modeling scientists will be expected with an emphasis on support of the oncology portfolio, and a particular focus on antibody-drug conjugates (ADCs). Opportunities in other therapeutic areas such as immunology and inflammation, metabolic diseases, and infectious diseases may be possible.
Responsibilities:
Work closely with multidisciplinary project teams to develop and implement mechanistic mathematical models of pharmacology to aid in target selection, target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, quantification of exposure-response relationships, biomarker characterization and early clinical trial designManage at least one junior colleague in oncology modeling and simulationCollaborate with research biology in the development of in-vitro assays and in-vivo models to generate data that inform preclinical-to-clinical translational PKPD modelsProvide expert support to project teams to design, execute and interpret quantitative pharmacology studiesPartner with colleagues in Clinical Pharmacology and Pharmacometrics to develop end-to-end alignment in model-informed drug development (MIDD) plans and to collectively advance the science and impact of mechanistic modeling and simulation.Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas, and interventional modalitiesKeep up to date with emerging literature in the area of mechanistic modeling and simulation sciencesContinue to build a personal track record of publication in the area of PKPD modeling and simulation and contribute to PDM's external publication/presentation goals consistent with our sustained investments in the area of modeling and simulationUp to 25% travel may be required.
Basic Qualifications:
Ph.D. degree or equivalent experience in pharmaceutical sciences, systems pharmacology, pharmacometrics, engineering, mathematics, physics or similar disciplines where modeling and simulation is emphasized.10+ years of pharmaceutical industry or related experience in developing and applying mechanism based quantitative pharmacology models (e.g. PBPK, PKPD, QSP) to guide project teams from early discovery to early clinical developmentExcellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulationAbility to effectively translate/condense/summarize outcomes of modeling and simulation analyses into useable information for multidisciplinary project teamsGood team player and communicator with ability to guide efficient communication of modeling and non-modeling concepts to leadershipAbility to work with on-site and remote colleaguesGood listener and ability to effectively interact with colleagues and leadership with a variety of backgroundsKeen to interact as a modeling and simulation expert with matrix project teams working closely with within PDM as well as biology, protein engineering, chemistry, safety and clinical scientistsStrong belief that modeling and simulation can have a significant positive impact on research projectsIn depth, hands-on knowledge of the state-of-the-art modeling and simulation software with (NONMEM, MATLAB, Monolix, Berkeley-Madonna, R or comparable applications)Ability to learn new areas of biological sciences and build on a solid foundation of quantitative skills to develop mechanistically relevant PKPD modelsAbility to keep up to date with and propose the implementation of scientific and technological developments in the area of PKPD modeling and simulationMotivated to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environmentCommitted to sharing technical expertise and the development of self and others
Preferred Qualifications:
Experience in working in the oncology disease area with a focus on ADCsFamiliarity with novel biotherapeutic modalities (bispecifics, Fc-fusions and other targeting agents)Familiarity with dispositional and pharmacological aspects of both small molecules and biologics.Prior experience in managing technical experts in modeling and simulation in a pharmaceutical industry settingCandidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
PHYSICAL/MENTAL REQUIREMENTS
Ability to perform advanced mathematical and logic calculations
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Up to 25% travel time may be required.
Work Location Assignment:On Premise
Relocation support available
#LI-PFE
The annual base salary for this position ranges from $149,200.00 to $248,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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