Senior Director, Clinical Pharmacology
Found in: beBee S US - 2 weeks ago
The Position:
At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join our Clinical Science team and take a central role in pioneering the future of healthcare.
As the Senior Director, Clinical Pharmacology, you'll be at the forefront of translating genetic insights into innovative treatments for patients. Your work will help drive the early clinical development programs for game-changing therapies, starting with small molecules targeting novel drivers of chronic kidney disease.
Maze Therapeutics has an exciting pipeline focused on renal, cardiac, and metabolic diseases that will enter the clinic in the coming years. In short, you'll play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives.
To succeed in this role, you'll need to thrive in a fast-paced, collaborative environment. As the Senior Director, Clinical Pharmacology across the Maze portfolio, you will partner closely with cross-functional leaders and team members to help design, conduct, and interpret the key clinical studies, including first-in-human, other clinical pharmacology and proof-of-concept patient trials. Your contributions will be highly visible and integral to the success of the Maze team.
Your Impact:
Generate and oversee the execution of the Clinical Pharmacology strategy for all development programs Collaborate with In Vivo Pharmacology and DMPK on development of translational PKPD models Serve as lead in design and analysis of FIH and other Phase 1 studies and participate in the design, execution, and analysis of other clinical trials for all clinical stage assets at Maze Conduct compliant data analyses including noncompartmental analyses using validated software, modeling & simulation, literature data analyses Co-author and review with cross-functional colleagues all clinical-regulatory documents, including IND/CTAs, clinical protocols and amendments, study reports, population PK reports, exposure-response analyses reports, relevant sections of investigator brochures, common technical documents, white papers and other similar documents Investigate, identify, develop, and optimize new methods & techniques in the field of clinical pharmacology. Act as lead PKPD scientist at Maze and critically evaluate relevant clinical pharmacology and regulatory advances, and integrate this knowledge into research and development programs Prepare and deliver scientific presentations and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators Partner with Clinical Development Operations and Vendor Management to identify, select, and oversee vendors and CROs to support program needs Develop and integrate timelines and budgets for clinical pharmacology activities with overall company timelines and goals, in close coordination with project management, clinical science, CMC, DMPK, nonclinical development, regulatory affairs and other stakeholdersAs a Senior Director, Clinical Pharmacology, we also expect our leaders to demonstrate the following Leadership Competencies:
Communication and Influence Role models clear communication and open two-way conversations Reinforces an environment where people feel heard and their opinions are valued Inspires followership despite differing initial opinions. Teamwork and Collaboration Champions collaboration and connection across Maze. Establishes team norms and expectations. Seeks opportunities to spotlight team and individual contributions in public forums. Execution and Results Develops recommendations to seize on opportunities and mitigate obstacles that could impact long-term success. Coaches others on resource management and work distribution/delegation. Aligns work to Maze’s strategy, mission, and vision. Develop Others and Self Develops staff capabilities to handle delegation of responsibilities. Encourages staff to develop and execute personal stretch goals. Identifies and recommends ways to increase inclusive leadership.Skills and Qualifications:
PhD in Pharmacology and/or PharmD with a minimum of 6+ years of drug development industry experience specifically in clinical pharmacology, pharmacometrics and/or modeling and simulations. Experience in the design and conduct of clinical trials and pharmacology data analysis and in nurturing relationships with CROs, consultants and other third Experience preparing regulatory submissions for INDs, NDAs, and/or MAAs and answering regulatory queries. Knowledge and good understanding of global regulatory guidelines for clinical pharmacology including requirements and current best practices for modeling, drug interaction assessment, intrinsic covariate evaluation, and pediatric study planning. Exceptional organizational, analytical, and communication skills, enabling you to translate corporate objectives into actionable plans that consistently deliver high- quality data on time and within budget. A positive and enthusiastic disposition, adaptability to changing environments, and unwavering personal and ethical standards in pursuit of corporate goals. Ability to travel as needed for vendor visits, industry conferences, regulatory meetings, advisory boards and other essential gatherings.About Maze Therapeutics
Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases such as chronic kidney disease. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze CompassTM Platform, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze CompassTM Platform, Maze is building a broad portfolio of wholly owned and partnered programs. Maze is based in South San Francisco.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for employees located in the San Francisco Bay Area is $262,000 to $321,000. Additionally, this position is eligible for an annual performance bonus.
Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.
Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
-
Senior Director, Clinical Pharmacology
3 days ago
South San Francisco, United States Maze Therapeutics Full timeThe Position: At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join our Clinical Science team and take a central role in pioneering the future of...
-
Senior Director, Clinical Pharmacology
7 days ago
South San Francisco, United States Maze Therapeutics Full timeJob DescriptionJob DescriptionThe Position:At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join our Clinical Science team and take a central role...
-
Senior Director, Clinical Pharmacology
Found in: beBee jobs US - 1 week ago
South San Francisco, California, United States Maze Therapeutics Full timeThe Position:At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join our Clinical Science team and take a central role in pioneering the future of...
-
Senior Director, Clinical Pharmacology
5 days ago
South San Francisco, United States Maze Therapeutics Full timeJob DescriptionJob DescriptionThe Position:At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join our Clinical Science team and take a central role...
-
Senior Director, Clinical Pharmacology
Found in: beBee jobs US - 1 week ago
South San Francisco, California, United States Maze Therapeutics Full timeThe Position:At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join our Clinical Science team and take a central role in pioneering the future of...
-
Senior Director, Clinical Pharmacology
3 days ago
South San Francisco, United States BioSpace Full timeJob DetailsThe Position: At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join our Clinical Science team and take a central role in pioneering the...
-
Senior Director, Clinical Pharmacology
3 days ago
South San Francisco, United States Maze Therapeutics Full timeThe Position:At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join our Clinical Science team and take a central role in pioneering the future of...
-
San Francisco, United States EPM Scientific Full timeWe are partnered with a growing precision medicine oncology biotechnology company based in San Francisco on an exciting Director/Senior Director opportunity! You will be providing guidance on all Clinical Pharmacology related programs such as authoring protocols, CSRs, data analysis, etc. A key role in this position is to provide PK/PD modeling and...
-
Director/Sr. Director, Clinical Pharmacology and PMx
Found in: Jooble US O C2 - 3 weeks ago
San Francisco, CA, United States EPM Scientific - Phaidon International Full timeWe are partnered with a growing precision medicine oncology biotechnology company based in San Francisco on an exciting Director/Senior Director opportunity! You will be providing guidance on all Clinical Pharmacology related programs such as authoring protocols, CSRs, data analysis, etc. A key role in this position is to provide PK/PD modeling and...
-
Director, Clinical Pharmacology
3 days ago
San Diego, United States Equillium, Inc. Full timeThe Director of Clinical Pharmacology will lead the development and implementation of clinical pharmacology strategies for small molecules and biologics within the company's portfolio. They will offer expertise in analyzing pharmacokinetics, absorption, distribution, elimination profiles, dose selection rationale, drug/food interaction potential, and QT...
-
Director, Clinical Pharmacology
1 day ago
San Diego, United States Equillium Inc Full timeThe Director of Clinical Pharmacology will lead the development and implementation of clinical pharmacology strategies for small molecules and biologics within the company's portfolio. They will offer expertise in analyzing pharmacokinetics, absorption, distribution, elimination profiles, dose selection rationale, drug/food interaction potential, and QT...
-
Director, Clinical Pharmacology
3 days ago
San Diego, United States Equillium Full timeThe Director of Clinical Pharmacology will lead the development and implementation of clinical pharmacology strategies for small molecules and biologics within the company's portfolio. They will offer expertise in analyzing pharmacokinetics, absorption, distribution, elimination profiles, dose selection rationale, drug/food interaction potential, and QT...
-
Director, Senior Managing
Found in: Jooble US O C2 - 3 weeks ago
San Francisco, CA, United States EPM Scientific - Phaidon International Full timeWe are partnered with a growing precision medicine oncology biotechnology company based in San Francisco on an exciting Director/Senior Director opportunity! You will be providing guidance on all Clinical Pharmacology related programs such as authoring protocols, CSRs, data analysis, etc. PhD in Pharmaceutical Sciences or a related field, or PharmD ~10...
-
Director/Senior Director of Pharmacometrics
Found in: Jooble US O C2 - 3 weeks ago
San Francisco, CA, United States EPM Scientific - Phaidon International Full timeJoin a dynamic, fast-paced biotechnology company based in South San Francisco dedicated to advancing oncology therapies! We are seeking a highly skilled and experienced Director/Senior Director of Pharmacometrics to contribute to the success of the company's drug development programs. Responsibilities: Develop and implement pharmacometrics...
-
Senior Director Regulatory Affairs
1 day ago
San Francisco, United States EPM Scientific Full timeTitle: Director/Senior Director of Regulatory Salary : $200,000 to $270,000 Summary: An Oncology based biotech client of ours is looking to fill their Director/Senior Director role based out of their facility in the San Francisco Bay Area. They are looking for very committed and passionate candidates who can collaborate with their colleagues to help build...
-
Director/Sr. Director, Clinical Pharmacology
3 days ago
San Diego, United States Arrowhead Pharmaceuticals, Inc. Full timeThe Position Arrowhead Pharmaceuticals is seeking an experienced Clinical Pharmacologist to join our team. Responsibilities * Lead the function of Clinical Pharmacology/Pharmacometrics for multiple programs in Phase 1-3 development * Contribute to clinical protocols design and execution; analyze data and prepare clinical study reports * Participate in...
-
Director/Sr. Director, Clinical Pharmacology
11 hours ago
San Diego, United States Arrowhead Pharmaceuticals, Inc. Full timeThe Position Arrowhead Pharmaceuticals is seeking an experienced Clinical Pharmacologist to join our team. Responsibilities * Lead the function of Clinical Pharmacology/Pharmacometrics for multiple programs in Phase 1-3 development * Contribute to clinical protocols design and execution; analyze data and prepare clinical study reports * Participate in...
-
Director, Preclinical Pharmacology
Found in: Appcast US C2 - 2 weeks ago
South San Francisco, United States SiteOne Therapeutics, Inc. Full timeAbout SiteOneSiteOne Therapeutics is a biopharmaceutical company developing treatments for hypersensitivity disorders of the nervous system such as pain, cough and epilepsy. Our values are scientific rigor, intensity, teamwork and commitment to our shared mission of developing transformative medicines for the benefit of patients. Our drug candidates are...
-
Director, Preclinical Pharmacology
Found in: Appcast Linkedin GBL C2 - 3 weeks ago
South San Francisco, United States SiteOne Therapeutics, Inc. Full timeAbout SiteOneSiteOne Therapeutics is a biopharmaceutical company developing treatments for hypersensitivity disorders of the nervous system such as pain, cough and epilepsy. Our values are scientific rigor, intensity, teamwork and commitment to our shared mission of developing transformative medicines for the benefit of patients. Our drug candidates are...
-
Director, Preclinical Pharmacology
2 weeks ago
South San Francisco, United States SiteOne Therapeutics, Inc. Full timeAbout SiteOneSiteOne Therapeutics is a biopharmaceutical company developing treatments for hypersensitivity disorders of the nervous system such as pain, cough and epilepsy. Our values are scientific rigor, intensity, teamwork and commitment to our shared mission of developing transformative medicines for the benefit of patients. Our drug candidates are...
