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Associate Principal Scientist
2 months ago
Job Description
Our Company has a rapidly growing interdisciplinary team of scientists in London and exciting plans to establish 'Skylab', a new laboratory space at the Francis Crick Institute. This will complement the construction of a new state–of–the–art Research and Discovery Centre in London's 'Knowledge Quarter' opposite King's Cross Railway station. Our new site will employ circa 800 people across our research and commercial divisions.
To deliver on our mission of turning breakthrough science into meaningful and impactful medicines, we plan to establish a new Translational Biomarker Group within Global Neuroscience Discovery. This team of laboratory and data scientists will drive scientific innovation in biomarker research to translate drug discovery programmes into the clinic for neurodegenerative disease, pain, and psychiatric disorders. Working collaboratively with discovery and clinical scientists, our biomarker experts will apply cutting edge lab technologies and Artificial Intelligence/Machine Learning tools to discover biomarkers that help determine the optimal dose and biological effects of our drugs and identify patients who are most likely to respond to treatment. This will allow our company to make progress in the battle against some of the most challenging diseases of the nervous system.
We are seeking a highly motivated Associate Principal Scientist (Associate Director level), Bioinformatics, Translational Biomarkers, Discovery Neuroscience to be based in Kings Cross, London.
Role overview:
In this newly established role, you will report to the Head of Translational Biomarkers, Neuroscience Discovery and will join a team of Global experts leading Biomarker research projects to translate drug discovery programmes into the clinic. You will contribute to the development of novel therapies to treat neurodegenerative diseases by integrating, analysing and interpreting data sets from clinical and preclinical studies to identify novel biomarkers for drug discovery projects. You will combine your understanding of disease biology with computational biology methods for the discovery of novel pharmacodynamic and predictive biomarkers for innovative drug targets.
What you will do:
Participate in cross–functional drug discovery teams and take the lead on in–silico identification of biomarkers for emerging drug discovery programmes, working in close collaboration with wet lab scientists, quantitative scientists, data scientists and AI/ML experts.Apply your knowledge of biological mechanisms and use computational biology methods for analysis of clinical data and multi–omic data from preclinical models and human studies to establish biomarkers of target modulation, disease heterogeneity and progression, and treatment response.Define and follow best practices for curating, standardising, and integrating diverse clinical and biological data sets from a variety of external and internal sources in a format suitable for bioinformatic analysis. Participate in the development and management of biomarker databases.Lead collaborations with internal research teams, CROs, academic collaborators, disease consortia and biobanks.Give presentations at internal meetings and externally at conferences.Contribute to internal scientific reports as required and publish science in high quality journals.What you will need to be successful in this role:
Qualifications:
PhD or Master's degree in biological sciences with significant experience applying computational methods to analyse and interpret large, complex data types for drug target or biomarker discovery within a biotech, pharmaceutical or academic setting.Required Experience:
A deep knowledge of biological mechanisms and application of bioinformatics within projects in a biomedical research environment.Previous experience assisting in the design of projects aiming to discover novel drug targets or biomarkers through mining of diverse clinical and non–clinical data sets such as biofluid measurements, imaging, transcriptomics, proteomics, etc.Experience of curating, standardizing (covering QC) and integrating diverse clinical and biological data sets from a variety of external and internal sources in a format suitable for analysis.Experience with development and application of methods to analyse and interpret large, complex data types (genomics, transcriptomics, single cell sequencing, proteomics, and metabolomics) for disease target or biomarker discovery.Experience of working collaboratively with data scientists and disease area biology experts.Desired Experience:
Background in neuroscience therapy areas such as neurodegenerative diseases, psychiatric disorders and/or pain disorders.Experience in translational biomarker projects within a drug discovery/development environment (e.g., pharmaceutical/biotech or academic setting).Fluent in common scripting and/or programming language (e.g., R, Python).Familiarity with public domain data sources.Experience working with external academic, biotechnology, and contract research organizations.Skills/Competencies:
Self–motivated and resourceful with a demonstrated ability to generate robust data outputs in a timely manner.Impacts programs through critical thinking and timely data–driven decision making.Well–developed oral and written communication skills, with an ability to communicate scientific and technical information effectively to non–experts in bioinformatics.Works effectively across functional areas and has a keen ability to engage internal and external team members in collaborative research.Demonstrates an enthusiasm for learning and applying new data science methods and workflows, working in close collaboration with AI/ML experts.Contributing to the research community through publication and conference presentation.Passion for innovation and problem–solving.Your role at our company is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At our company, we're inventing for life.
Closing date for applications: 12th August 2024
We are a research–driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research–driven enterprise dedicated to world–class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to identify a compound that is effective against a disease target. Using innovative thinking, state–of–the–art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively for the common good. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
