Scientist, Bioinformatics

3 months ago

Pearl River, United States Pfizer Full time
WHY PATIENTS NEED YOU

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

POSITION SUMMARY

Pfizer is seeking a talented, self-motivated Scientist (Bioinformatics) with background in developing analytical algorithm, data processing pipeline to support mRNA vaccine data analytics and next generation sequencing efforts in vaccines R&D team at Pearl River. Responsibilities will be driving therapeutic innovation through contributing to the vaccine development. You will apply analytical skills and develop bioinformatics tools used for whole genome sequencing, targeted sequencing, RNA sequencing and single cell sequencing. You will analyze sequence data and provide bioinformatics and data science support to various mRNA vaccines program. Work and documentation are to be done in a compliant manner according to relevant SOP guidelines and cGLP guidelines where appropriate. You will be part of a dynamic team and should possess a strong work ethic and collaborative spirit.

POSITION RESPONSIBILITIES
Develop and manage automated next generation sequencing (NGS) pipelines to support pathogen or host genome sequencing projects
Implement various open source bioinformatic pipelines and interpret analytical results to support mRNA vaccines' preclinical and clinical programs
Experience and knowledge about bulk RNAseq, single cell RNAseq, TCR profiling, and BCR profiling
Develop novel algorithms and workflow for the analysis of vast amount data spanning different data types and provides scientific insights to guide vaccine design.
Present analytical results and review of literature at group meetings as needed. Maintain laboratory notebooks in compliance with the Pfizer Laboratory Notebook Policy.
Collaborate extensively with those from other scientific disciplines from within the group, from other subdivisions of Vaccines R&D, from other divisions of Pfizer

MINIMUM QUALIFICATIONS
Degree in computer science, bioinformatics, data science, computational biology or related field is required.
Bachelor's degree with 8~10 years of experience or master's degree with additional 6-8 years of related experience is preferred. This is NOT a PhD position.
Extensive experience in analyzing multi-omics next generation sequencing data (e.g., genetics, bulk RNA-seq, single-cell RNA-seq, spatial omics, proteomics, etc.) for biomedical research.
Proficient coding/scripting in Python, R. Familiar with Biopython, Tidyverse, Bioconductor, scikit-learn
Familiar with Linux environments, high-performance computing and/or cloud computing environment and broad experience with open-source bioinformatics tools to generate scientific insight.
Must be comfortable with fast-paced environment handling multiple projects simultaneously with different priorities and timelines. Strong motivation, passion and commitment to interdisciplinary science and techniques.

PREFERRED QUALIFICATIONS
Familiar with various sequencing platforms: Ion Torrent, Illumina, PacBio, Nanopore, 10x genomic
Familiar with public resources: GISAID, NCBI, EMBL, UniProt, PDB
Knowledge about vaccine development and immunology

Job Location: On premise with relocation support available

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development