Research Technician III

3 weeks ago

Seattle, United States Fred Hutchinson Cancer Center Full time

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.


With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.


At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

 

The Ring Lab of Synthetic and Systems Immunopharmacology is located within the Translational Science and Therapeutics Division and is a member of the Immunotherapy Integrated Research Center (IIRC). Their primary focus is on developing unique and fi rst-in-class therapeutic drugs for cancer immunotherapy using cutting-edge protein engineering with directed evolution. The lab has developed therapeutics that are currently in clinical trials, such as ST-067 (a "decoy-resistant" IL-18), MDNA-11 (CD122-biased IL-2), and ALX-148/evorpacept (an ultra-high affi nity SΙRPα decoy). Moreover, the Ring Lab is actively working on developing platforms for identifying new targets in cancer immunotherapy. These technologies include the REAP platform for discovering autoantibodies in patient samples, and high-throughput techniques in synthetic antibody engineering and proteogenomics to pinpoint new tumor antigens.

 

Responsibilities

The Research Technician III will work closely with Dr. Ring, lab manager Alison Almeda, and senior lab members to design and execute experiments related to the lab's scientific goals. This person will be responsible for analyzing, interpreting, and reporting experimental results on a shared lab database, in group meetings, and have the opportunity to contribute to scientific publications. The technician will perform research tasks in combinatorial and high-throughput biology, including autoantibody profiling with REAP, as well as protein engineering and antibody discovery with yeast-surface display. Related actvities to support this work will also include protein biochemistry, tissue culture, and lab maintenance.

 

Performs the duties of the Research Technician II plus:

  • May lead or supervise other laboratory personnel and be responsible for the daily operation of the laboratory.
  • Collaborate with primary investigator, and assist in designing experiments; examine proposals to determine projects and methodologies best suited to research objectives and the overall goals of the laboratory.
  • Summarize and write for publication or presentation the results of research projects, often as co-author or author. Edit and write reports of research.
  • Consult with the Principal Investigator and others in the scientific community on problems and related projects.
  • Determine the most suitable methods to be used in research; determine appropriate experimental controls.
  • Conduct literature reviews to assist in determining most suitable methods to be used in research.

Qualifications

MINIMUM QUALIFICATIONS:

  • Senior level position requiring extensive experience in a laboratory. 
  • Master's degree in a related scientific field or equivalent experience.

PREFERRED QUALIFICATIONS:

 

  • Must have scientific knowledge in the area of immunology, protein engineering, directed evolution, or similar field.
  • Hands-on research experience with yeast display/phage display, protein biochemistry, and/or structural biology
  • 2 years previous experience working in a molecular biology laboratory.
  • Experience with or willingness to adopt procedures to work under BSL2+ safety procedures to handle potentially infectious samples.
  • Scientific curiosity, self-motivated and able to take instruction and correction and to follow directions, good organizational skills, the ability to work and think independently, but also be a team player.
  • Show initiative and be willing to take up new laboratory skills and communicate well with other members of the research team. Strong skills in data collection and laboratory record keeping are mandatory.
  • Experience with immunological techniques, such as flow cytometry.
  • Computer skills and experience with statistical analysis and data presentation.

Please include a cover letter with your application detailing your interest in this position.

 

The annual base salary range for this position is from $67,728.00 to $99,236.00, and pay offered will be based on experience and qualifications.  

This position may be eligible for relocation assistance. 

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