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Protein Mass Spectrometry, Molecular Analytics

3 months ago

Thousand Oaks, United States Amgen Full time

HOW MIGHT YOU DEFY IMAGINATION?

Youve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Protein Mass Spectrometry, Molecular Analytics - Senior Scientist

Live

What you will do

Lets do this. Lets change the world. In this vital role you will be part of the Molecular Analytics group providing scientific and technical expertise to support early discovery research through to later stage molecule optimization and late-stage selection of Amgens pipeline of drug candidates. This position is an exciting opportunity to unlock the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics.

Responsibilities

  • Perform protein, peptide, PTM, glycan analysis and characterization by mass spectrometry, using RPLC-MS, RPLC-MS/MS, MALDI-MS, native-MS and other hyphenated MS analytical capabilities to support the diverse early-stage pipeline.

  • Execute and develop sensitive high-throughput, low material consumption assays to assess mAbs, MsAbs, mAb-fusions, ADCs and other biotherapeutics physical, chemical, thermal and colloidal stability and manufacturability using multiple analytical techniques, including, but not limited to, LC-MS, LC-MS/MS.

  • Implement new analytical technologies, including but not limited to MS, that will support the early-stage pipeline.

  • Generate, process and use large analytical data sets for the application of biomolecule attribute and manufacturability prediction and machine learning purposes

  • Manage timelines, therapeutic projects and cross functional teams and departmental collaborations

  • Communicate (verbal and in written) scientific concepts and results

  • Work independently in advancing projects and studies within required deadlines

  • Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen

  • Demonstrate external scientific eminence in the form of peer-reviewed publications and conference presentations

  • Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings

    Win

    What we expect of you

    We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.

    Basic Qualifications:

  • Doctorate degree PhD OR PharmD OR MD and Analytical Chemistry, Biochemistry or equivalent OR

Masters degree and 3 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent experience OR

Bachelors degree and 5 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent experience

Preferred Qualifications:

PhD or Post-Doc level qualification with an emphasis in mass spectrometric analytical characterization.

A deep understanding of mass spectrometric, intact and sub-unit protein mass analysis, bottom up RPLC-MSMS approaches and other protein structural analytical methods and techniques will be advantageous. Experience with Agilent LC-TOF/QTOF MS, Thermo Orbitrap Fusion Tribrid MS is highly desired.

1-3 years of biopharmaceutical experience with therapeutic protein analysis is advantageous.

Knowledge of Protein Metrics and Genedata Software is advantageous.

Experience with Bruker MALDI-TOF will be advantageous.

Experience using automation (for example Assay MAP Bravo or TECAN) is a plus.

A track record of publications and conference presentations is essential.

Knowledge of AI/ML processes is a plus.

Knowledge of multiple chromatographic software (ChemStation, Chromeleon) would be advantageous.

Relevant experience working as part of a multidisciplinary team in a biopharmaceutical setting would also be an advantage.

Thrive

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

Stock-based long-term incentives

Award-winning time-off plans and bi-annual company-wide shutdowns

Flexible work models, including remote work arrangements, where possible

Apply now for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.