Senior Scientist, Oligonucleotide Chemistry

3 weeks ago

Waltham, United States Dyne Therapeutics Full time
Company Overview:

Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD).

Role Summary:

As a member of the Platform Oligo innovation team, the successful candidate will contribute to the development of Dyne’s oligonucleotide chemistry platform and enable the discovery of novel oligonucleotide therapeutics. This individual will be responsible for building an internal oligonucleotide chemistry lab and will lead the design, synthesis, purification, and analysis of oligonucleotides and their conjugates. The position requires a combination of deep technical expertise in oligonucleotide synthesis and in-depth knowledge of oligonucleotides as a therapeutic modality.

This role is based in Waltham, MA without the possibility of being a remote role. Applicants must be able to relocate to the area.

Primary Responsibilities Include:

Independently perform solid phase synthesis of oligonucleotides with diverse sugar and backbone modifications at various scales Troubleshoot and optimize synthesis methods to produce high quality oligonucleotides of various lengths Perform purification (anion exchange, reverse phase), analysis (HPLC/UPLC), characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates Explore novel chemistries and designs to improve the DMPK and safety properties of oligonucleotides Manage hit-to-lead optimization process and deliverables Interact with the biology and preclinical groups to deliver clinical candidates Multi-task across several projects and manage time effectively to achieve results Collect, present, and discuss data at internal team meetings

Education and Skills Requirements:

PhD in chemistry or related discipline with a minimum of 4 years of experience in oligonucleotide synthesis -prior postdoctoral experience is preferred- or MSc with at least 7 years of industrial experience in the biotechnology industry Strong experience with the operation of oligonucleotide synthesis machinery (Mermade), and AKTA purification unit Working knowledge of RNA biology to enable collaboration across functions Experience with ASO, siRNA or other DNA/RNA targeting modalities Experience in nucleoside chemistry and bioconjugation are a plus

#LI-Onsite

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

  • Senior Scientist, Oligonucleotide Chemistry

    4 weeks ago

    Waltham, Massachusetts, United States Dyne Therapeutics Full time

    Company Overview:Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCETM platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue....

  • Sr. Scientist, Medicinal Chemistry, TTD, Early Oncology

    4 weeks ago

    Waltham, Massachusetts, United States AstraZeneca GmbH Full time

    Sr. Scientist, Medicinal Chemistry, TTD, Early OncologyThis role is part of an important strategy to deliver highly specific therapeutics including, small molecule, peptide and antibody drug/prodrug/degrader conjugates with various targeting modalities to treat cancer.Design and execute synthetic strategies to access complex target molecules (a strong...

  • Associate Scientist

    4 weeks ago

    Waltham, Massachusetts, United States Cambrex Full time

    Company Information You Matter to Cambrex. Cambrex is a leading global contract development and manufacturing organization (CDMO) that provides drug substance, drug product, and analytical services across the entire drug lifecycle. With more than 40 years of experience and a growing team of over 2,400 professionals servicing global clients, Cambrex is a...

  • Scientist

    2 weeks ago

    Waltham, United States Alkermes Full time

    Position Summary The Scientist position within Analytical Development performs small molecule analytical activities within a growing, dynamic Pharmaceutical Development organization. They develop new methods using chromatographic, characterization, and wet chemistry techniques to enable small molecule drug substance and drug product development throughout...

  • Scientist

    3 weeks ago

    Waltham, United States Alkermes Full time

    Position Summary The Scientist position within Analytical Development performs small molecule analytical activities within a growing, dynamic Pharmaceutical Development organization. They develop new methods using chromatographic, characterization, and wet chemistry techniques to enable small molecule drug substance and drug product...

  • Associate Scientist

    4 weeks ago

    Waltham, United States Cambrex Full time

    Company Information You Matter to Cambrex. Cambrex is a leading global contract development and manufacturing organization (CDMO) that provides drug substance, drug product, and analytical services across the entire drug lifecycle. With more than 40 years of experience and a growing team of over 2,400 professionals servicing global clients, Cambrex is a...

  • Senior Scientist, BA

    4 weeks ago

    Waltham, Massachusetts, United States AstraZeneca Full time

    Senior Scientist, BA/DMPK (Oncology)The Oncology Drug Metabolism and Pharmacokinetics department is looking for an individual who has a passion for BA and DMPK science, applied to Cancer biology.As a BA scientist, you will provide drug discovery and development bioanalytical input and support for the analysis of in vivo PK, PD, and in vivo samples across the...

  • Senior Data Scientist

    1 week ago

    Waltham, United States eTeam Full time

    Job Title: Senior Data Scientist, DER & Policy Forecasting, Load Forecasting & Analytics Waltham, MA and Hicksville, NY Pay Rate: 120KJob Purpose The Analytics & Load Forecasting team produces electric and gas forecasts for Clients. As a Senior Data Scientist, you will develop long-term forecasts for distributed resources (including solar PV, energy...

  • Associate Scientist

    1 week ago

    Waltham, United States Cambrex Corp. Full time

    Company Information **You Matter to Cambrex.** Cambrex is a leading global contract development and manufacturing organization (CDMO) that provides drug substance, drug product, and analytical services across the entire drug lifecycle. With more than 40 years of experience and a growing team of over 2,400 professionals servicing global clients, Cambrex is...

  • Sr. Scientist/Associate Principal Scientist

    2 weeks ago

    Waltham, United States Alkermes Full time

    Position Summary The Senior Scientist/Associate Principal Scientist position within Analytical Development leads small molecule analytical activities within a growing, dynamic Pharmaceutical Development organization. They will collaborate with cross-functional teams on analytical method development, molecule characterization, testing and analysis throughout...

  • Sr. Scientist/Associate Principal Scientist

    1 week ago

    Waltham, United States Alkermes, Inc. Full time

    Position SummaryThe Senior Scientist/Associate Principal Scientist position within Analytical Development leads small molecule analytical activities within a growing, dynamic Pharmaceutical Development organization. They will collaborate with cross-functional teams on analytical method development, molecule characterization, testing and analysis throughout...

  • Senior Scientist

    16 hours ago

    Waltham, United States Integrated Resources, Inc ( IRI ) Full time

    Title: Senior Scientist / Non Clinical Safety Evaluation Location: Waltham, MADuration: 6+ Months Part Time role : 20 hours per week Position Summary:Primary responsibility for the Scientist/Senior Scientist in NSE is to ensure timely and high-quality deliverables from NSE to meet Mural Oncology’s Discovery and Development goals; these deliverables include...

  • Senior Scientist

    2 weeks ago

    Waltham, United States Integrated Resources, Inc ( IRI ) Full time

    Title: Senior Scientist / Non Clinical Safety Evaluation Location: Waltham, MADuration: 6+ Months Part Time role : 20 hours per week Position Summary:Primary responsibility for the Scientist/Senior Scientist in NSE is to ensure timely and high-quality deliverables from NSE to meet Mural Oncology’s Discovery and Development goals; these deliverables include...

  • Senior Scientist, Bioanalysis

    1 week ago

    Waltham, United States Dyne Therapeutics Full time

    Company Overview: Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle...

  • Principal Scientist

    3 weeks ago

    Waltham, Massachusetts, United States Alkermes Full time

    Job DescriptionPosition Summary:The Principal Scientist position within Analytical Development provides technical leadership for small molecule analytical methodologies and grows as a subject matter expert both within and outside the department as part of a growing, dynamic Pharmaceutical Development organization. They will work within the Analytical...

  • Senior Scientist, Bioanalysis

    1 week ago

    Waltham, Massachusetts, United States Dyne Therapeutics Full time

    Company Overview:Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCETM platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue....

  • Principal Scientist, Protein Analytics

    1 week ago

    Waltham, Massachusetts, United States Dragonfly Therapeutics Full time

    Principal Scientist, Protein AnalyticsDragonfly Therapeutics is seeking a Principal scientist who brings enthusiasm, intellectual curiosity, scientific rigor, and a desire to help drive novel immunotherapy programs forward. The candidate must be independent, goal-oriented, flexible, and able to work efficiently across multiple projects. We are searching for...

  • Associate Director, Clinical Scientist

    4 weeks ago

    Waltham, United States Dyne Therapeutics Full time

    Company Overview: Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle...

  • Associate Director, Clinical Scientist

    2 weeks ago

    Waltham, United States BioSpace Full time

    Job DetailsCompany Overview: Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to...

  • Associate Director, Clinical Scientist

    3 weeks ago

    Waltham, Massachusetts, United States Dyne Therapeutics Full time

    Company Overview:Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCETM platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue....