Current jobs related to Senior Process Engineer, MSAT - Bedford - Obsidian Therapeutics
-
Senior Manufacturing Process Engineer
1 week ago
New Bedford, Massachusetts, United States Futran Tech Solutions Pvt. Ltd. Full timeJob Title: Senior Manufacturing Process EngineerJob Summary:Futran Tech Solutions Pvt. Ltd. is seeking a Senior Manufacturing Process Engineer to develop and execute remediation plans for Affera OQW PLX findings. The ideal candidate will have experience with CAPA, root cause analysis, and six sigma methodologies.Responsibilities:• Develop and execute...
-
Senior Process Engineer
2 weeks ago
Bedford Park, United States Ingredion Full timeTITLE: Senior Process Engineer - DextroseLOCATION: Argo Plant, Bedford Park, IL REPORTS TO: Manager, Process Engineering The Senior Process Engineer will provide technical leadership and solutions to the Argo dextrose operations team. This role will collaborate with operations associates, maintenance technicians, and leadership to ensure effective...
-
Senior Process Engineer
2 weeks ago
Bedford Park, United States Ingredion Full timeTITLE: Senior Process Engineer - Dextrose LOCATION: Argo Plant, Bedford Park, IL REPORTS TO: Manager, Process Engineering The Senior Process Engineer will provide technical leadership and solutions to the Argo dextrose operations team. This role will collaborate with operations associates, maintenance technicians, and leadership to ensure effective...
-
Senior Quality Process Engineer
2 weeks ago
New Bedford, Massachusetts, United States Michael Page Full timeOur client, a leading producer of specialized nylon resins, is seeking a Senior Quality Process Engineer to join their team. As a key member of the organization, you will provide quality support to operations, identifying areas for improvement and leading quality projects. You will analyze data to drive continuous improvement initiatives, support new product...
-
Senior Project Engineer
2 months ago
Bedford Park, Illinois, United States Ingredion Full timeJob SummaryWe are seeking a highly skilled Senior Project Engineer to join our team at Ingredion. As a key member of our engineering team, you will be responsible for driving process improvements and leading capital projects to optimize manufacturing efficiency and reduce costs.Key ResponsibilitiesDesign and implement capital projects to improve...
-
Senior Quality Process Engineer
1 week ago
Bedford, United States Michael Page Full timeThe Senior Quality Process Engineer, Plastics, will lead quality initiatives and oversee improvement projects within manufacturing operations. This role will focus on enhancing product quality and ensuring successful new product launches through close collaboration with internal teams.Client DetailsMy client is a leading producer of specialized nylon resins,...
-
Senior Quality Process Engineer
2 weeks ago
New Bedford, Massachusetts, United States Michael Page Full timeAbout Our ClientOur client is a leading producer of specialized nylon resins, offering a wide array of high-performance materials for diverse industries. They focus on customized polymer solutions, responding swiftly to customer needs through versatile manufacturing and polymerization capabilities.Job DescriptionThe Senior Quality Process Engineer will...
-
Senior Signal Processing Engineer
1 week ago
New Bedford, Massachusetts, United States The MITRE Corporation Full timeWe are seeking a highly skilled Senior Signal Processing Engineer to join our team at The MITRE Corporation. This individual will apply innovative expert-level signal processing and analytical expertise to a wide variety of communications, sensor, dynamic spectrum, and related applications.The successful candidate will have a strong background in signal...
-
Senior Project Engineer
2 weeks ago
Bedford Park, United States Ingredion Incorporated (NA-US) Full timeJob Summary:We are seeking a Senior Project Engineer to drive process improvement and optimize manufacturing operations at Ingredion Incorporated (NA-US). The successful candidate will have a strong background in engineering and project management, with experience in the Wet Milling industry or relevant sectors.Key Responsibilities:Design and implement...
-
Senior Manufacturing Engineer
1 month ago
Bedford, New Hampshire, United States Gabriele & Company Full timeSenior Manufacturing EngineerGabriele & Company is partnering with a rapidly growing company to find an experienced Senior Manufacturing Engineer. This role will play a critical part in driving process improvements and ensuring the highest quality products.Key Responsibilities:Evaluate and optimize manufacturing processes to reduce costs and improve...
-
Senior Optical Engineer
3 weeks ago
Bedford, United States Jobot Full timeDice is the leading career destination for tech experts at every stage of their careers. Our client, Jobot, is seeking the following. Apply via Dice today!A rapidly growing, 300 person, Optical Device Development company is currently looking for a Senior Optical Engineer!This Jobot Job is hosted by: Ryan SullivanAre you a fit? Easy Apply now by...
-
Senior Quality Process Engineer
1 week ago
Bedford, NH, United States Michael Page Full timeThe Senior Quality Process Engineer, Plastics, will lead quality initiatives and oversee improvement projects within manufacturing operations. This role will focus on enhancing product quality and ensuring successful new product launches through close collaboration with internal teams.Client DetailsMy client is a leading producer of specialized nylon resins,...
-
Senior Systems Engineer
1 week ago
Bedford, Massachusetts, United States DCS Corp Full timeJob Title: Senior Systems EngineerJob Summary:DCS Corp is seeking a highly skilled Senior Systems Engineer to provide support to the Air Force Life Cycle Management Center/PEO Digital Directorate (AFLCMC/HB). The ideal candidate will have a strong background in systems engineering and experience working with the DoD acquisition process.Key...
-
Senior Medical Device Engineer
2 weeks ago
Bedford, Massachusetts, United States Werfen Full timeJob Title: Senior Medical Device EngineerWerfen is a leading company in specialized diagnostics, with a strong focus on innovation and quality. We are seeking a highly skilled Senior Medical Device Engineer to join our team.Job Summary:The Senior Medical Device Engineer will be responsible for designing, developing, and supporting medical diagnostic systems....
-
Process Engineer Co-Op
2 weeks ago
Bedford Park, Illinois, United States Inova Health System Full timeProcess Engineer Co-Op OpportunityWe are seeking a highly motivated and detail-oriented Process Engineer Co-Op to join our team at Inova Health System. As a Process Engineer Co-Op, you will have the opportunity to work closely with senior engineers and managers to monitor process conditions, provide engineering support, and implement process improvements.Key...
-
Process Engineer Co-op
1 month ago
Bedford Park, Illinois, United States Ingredion Full timeProcess Engineer Co-op OpportunityIngredion is seeking a highly motivated and detail-oriented student to join our Process Engineering team as a Co-op. In this role, you will have the opportunity to work alongside senior engineers and managers to monitor process conditions, provide engineering support, and implement process improvements.Key...
-
Senior Staff Engineer
1 month ago
Bedford, New Hampshire, United States Gale Associates Full time{"h1": "Senior Staff Engineer at Gale Associates", "p": "We are seeking a highly skilled Senior Staff Engineer to join our team at Gale Associates, Inc. in Bedford, NH. As a Senior Staff Engineer, you will be responsible for leading exterior building envelope renovations, analysis, design, and construction administration projects. Key Responsibilities: *...
-
Senior Systems Engineer
2 weeks ago
New Bedford, Massachusetts, United States DCS Corp Full timeJob Title: Senior Systems EngineerWe are seeking a highly skilled Senior Systems Engineer to join our team at DCS Corp. As a Senior Systems Engineer, you will be responsible for providing technical leadership and expertise in the design, development, and integration of complex systems.Key Responsibilities:Provide technical guidance and support to...
-
Manufacturing Process Engineer
2 weeks ago
Bedford, Massachusetts, United States Entegris Full timeJob Title: Manufacturing Process EngineerEntegris is seeking a highly motivated and experienced Manufacturing Process Engineer to join our team. As a key member of our Manufacturing Operations team, you will play a critical role in driving initiatives to increase output, reduce scrap and rework, eliminate waste, improve overall efficiency, and ensure quality...
-
Senior Systems Engineer
2 months ago
Bedford, Massachusetts, United States DCS Corp Full timeAbout the RoleWe are seeking a highly skilled and experienced Senior Systems Engineer to join our team at DCS Corp. As a key member of our engineering team, you will be responsible for providing technical leadership and expertise in the design, development, and implementation of complex systems.Key ResponsibilitiesConduct system reviews and analyses to...
Senior Process Engineer, MSAT
2 months ago
Senior Process Engineer, MSAT (Cell Therapy/Viral Vectors)
Bedford, MA
About Us…
Obsidian Therapeutics is expanding the reach of TIL therapy. We are pioneering engineered tumor infiltrating lymphocyte (TIL) therapies to deliver transformative outcomes for patients suffering from solid tumor malignancies. Obsidian’s programs apply our cytoDRiVE® platform technology to express regulated therapeutic proteins to enhance anti-tumor activity. We’re currently investigating our lead program OBX-115 and enrolling patients in an ongoing clinical trial in advanced or metastatic melanoma.
We’re proud of our diverse talented team and committed to cultivating an environment where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our research team is based in the heart of Cambridge, MA, and our Technical Development, Manufacturing & Quality team is based in our facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.
On April 3, 2024, we announced closure of a significantly oversubscribed $160.5 million Series C financing with a top-tier syndicate of life science investors led by new investor, Wellington Management. Proceeds from the financing will advance Obsidian’s lead program in its ongoing trials. We’re focused on enrolling patients and reaching key clinical and regulatory milestones, as well as manufacturing scale-up ahead of pivotal trial readiness.
Our Opportunity…
We’re expanding our External Manufacturing/ Manufacturing Science and Technology (MSAT) team for a Senior Process Engineer to support manufacturing for our clinical trials in metastatic melanoma and non-small cell lung cancer. The ideal candidate will have experience overseeing work completed at a CDMO/CMO and a strong background in cGMP requirements and their application to viral vector and mammalian cell culture manufacturing. In this role, you’ll work closely with the MSAT organization, and stakeholders in the CMC (internal) and CDMO (external) teams to oversee technology transfer and manufacturing of our engineered autologous cell therapies. As part of our Technical Development and Manufacturing department you will be a vital part of a highly collaborative team working to achieve the Obsidian’s vision by translating innovative science into medical breakthroughs for patients, starting with our lead program cytoTIL15 engineered to make TILs more effective for more patients.
This is a unique opportunity to be a contributor in a well-funded clinical company with blue chip investors, field-leading advisors, best-in-class partners, and an experienced team. You'll help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need.
You Will…
Collaborate with cross-functional teams, including the CDMO joint project team, Obsidian Process and Analytical Development, Quality Assurance, Quality Control, and Regulatory to assure effective tech transfers and start-up of new manufacturing processes according to agreed upon timelines in support of business objectives. Act as a Person-in-Plant (PIP) at Obsidian’s CDMO facilities by maintaining on-site presence as needed, leading up to and during manufacturing. Perform detailed review, including technical oversight and ownership of batch records, validation protocols, and reports to ensure appropriate and complete content. Analyze the process monitoring database for the processes you are responsible for maintaining. Liaise with cross-functional teams (internal and external) to resolve manufacturing issues along with ownership of process-related manufacturing investigations/deviations, change controls, complaints, and CAPAs to meet Obsidian requirements. Build and maintain strategic relationships within the CDMO organization and with key internal stakeholders. Provide technical expertise and participate in FMEA and HAZOP related activities to support quality by design (QBD). Partner with Obsidian Process Development to support Process Characterization studies. Contribute to Process Validation/Process Performance Qualification (PPQ) activities in support of licensure activities.You Bring…
Core Qualifications
Bachelor’s degree in biological sciences, (bio)chemical engineering, or related discipline with 5+ years of experience (or MS with 3+ years) working in a Manufacturing or MSAT role in the Cell Therapy and/or Viral Vector space. Strong understanding of aseptic processing and cGMP requirements and their application to viral vector and mammalian cell culture manufacturing. Successful experience working at or overseeing work completed at a CDMO/CMO including change, deviation, CAPA, and Tech Transfer management. Prior experience leading and documenting risk assessments (SIPOC, FMEA, and/or HAZOP) and root cause analysis (5-why, fishbone/Ishikawa). Strong competence in analyzing and interpreting manufacturing process data using statistical software such as JMP or Minitab. Familiarity with FDA and EMA guidance documents relevant to cell and gene therapy. Confidence and good judgement to elevate relevant issues to management. Proven initiative, problem-solving, and ability to manage matrixed projects and tasks to completion. A highly collaborative working style – build trusting relationships, and share ideas and feedback, productively challenge own and others’ assumptions to generate new ideas and facilitate better outcomes. Self-motivation and a proven ability to work with general direction to meet objectives and timelines. Flexibility, ability to adapt to changes and priorities to fulfill our mission, including occasional after-hours or weekend oversight of ongoing manufacturing runs as needed. Excellent communication skills, strong technical writing and scientific skills. Ability to travel up to 30% of the time.Bonus Qualifications
Experience with PPQ (process validation). Familiarity with analytical instrumentation/methods employed for cell and vector characterization (flow cytometry, ELISA, cell counting, ddPCR, etc.) is a plus.
Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.
