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Scientist - Oligonucleotide Analysis
3 months ago
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by
discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.
The LIGM RNA Group is seeking an independent, self-motivated, and agile analytical scientist with good hands-on experiences in analytical methodologies for the characterization and analysis of small molecules and oligonucleotides. The ideal candidate will have experiences in multiple analytical techniques, including UPLC, LC-MS, CD, SPR, DLS, gel electrophoresis, osmolality, UV-vis, and fluorescence-based methods, as well as experiences in analytical method development and troubleshooting. They must be computer savvy, with the ability to navigate multiple instrument control software and data analysis environments, possess strong technical problem-solving skills, and have an internal motivation to work independently and achieve efficient, quality results in a fast-paced environment.
Responsibilities:
Analysis of chemically synthesized oligonucleotides: UPLC and LC-MS for purity determination.Source, explore, and implement the latest separation science and technologies for the purification and characterization of oligonucleotides and their conjugates (carbohydrate, lipid, peptide, protein).Perform downstream processing to purify modified oligonucleotides using RP purification, ion-exchange chromatography, spin filtration, and size exclusion chromatography to support semi-preparative and preparative method development activities.Operate, troubleshoot, and maintain lab instruments such as but not limited to UPLC, LC-MS, osmometer, and nano drop in good operational condition.Perform bioassay sample preparation, gel electrophoresis, and surface modification (SPR sensor chips, magnetic beads) to support method development based on bioanalytical background knowledge, and perform organized, presentable data collection and analysis.Learn new technologies quickly and apply effective scientific concepts and methods across multiple areas.Process and present data leveraging Microsoft Office apps and GraphPad for data organization.Document experiments, data, technical reports, and findings electronically in an accessible manner and good documentation practice.Present findings, progress, and data proactively and regularly in group and department meetings.Possess a collaborative and willing-to-share mindset with excellent verbal and written communication skills, excellent presentation skills, and attention to detailsAbility to follow Environmental Health and Safety (EHS) guidelines while performing tasks.Basic Qualifications:
Bachelors or Masters Degree in Analytical Chemistry, Biochemistry, Chemistry, Food Science, or a related scientific field, with 0+ years of relevant post-graduate experienceAdditional Skills/Preferences:
Strong analytic thinking skills. Demonstrated ability to articulate issues, and extract and synthesize complex issues into key focus.Experience in separations science, including but not limited to RP, HILIC, HIC, IEX, SEC and CE.Experience in mass spectrometry including ESI ionization with a range of mass spectrometer designs (QToF, Orbitrap, QQQ).Experience in UV-vis, CD, SPR and fluorescence-based assays for oligonucleotide analysisExperience in gel electrophoresis for oligonucleotide characterization.Prior working experience in bioanalysis is a big plus.Highly self-motivated and self-driven attitude with ability to own and drive projects into success.Strong organizational and communication skills and effective people skills.Capable of continuous learning, open-minded, highly organized, and detail oriented.Ability to balance multiple activities, prioritize and handle ambiguity.Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.
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