Senior / Principal Research Associate / Scientist, mRNA and LNP production

4 weeks ago


Boston MA, United States Amplitude Therapeutics Full time

Company Summary:

Amplitude Therapeutics is a seed-staged biotechnology company focusing on developing the next generation of RNAs to fully unlock the therapeutic potential of RNA biology. We are founded by leaders in the RNA and non-viral therapy fields and backed by premier Biotech VCs.

Position Summary:

The key function of this lab-based role is to lead multiple steps in the manufacturing of RNA, including DNA production, RNA in vitro transcription, RNA purification and RNA analytics to support key preclinical studies of new RNA therapeutics. Additionally, this candidate will contribute to the formulation and characterization of LNPs. The ideal candidate will have prior experience manufacturing DNA and RNA, as well as an enthusiastic desire to lead and execute manufacturing projects key to the companys success. Careful organization, a can-do attitude, and a desire to add responsibilities and expertise are also central to this role. This role will have the extensive opportunities to interact with and learn from different cross-functional teams focused on novel RNA therapeutics and preclinical development in addition of manufacturing and analytics. We offer an inclusive, dynamic, and fast-paced work environment, where team members have ample opportunity to make meaningful impact on our mission and shape our growing company.

Key Responsibilities:

Production and tracking of plasmid DNA (cloning and mini-/maxiprep) and in vitro transcription and purification of RNA

Assist in the formulation and characterization of mRNA-LNPs

Maintain robust organization of RNA and LNP projects and timelines

Optimize and scale RNA and LNP production, purification, and analytical workflows to fit company needs

Collaborate cross-functionally with RNA and in vivo focused teams.

Qualifications

Title is commensurate with experience. BS/MS in Biology, Chemistry, Bio/Chemical Engineering or a related field with 2-8 years of relevant experience. Early career PhD scientists with relevant manufacturing experience are also welcomed to apply.

Hands-on experience with RNA/DNA production is required.

Experience with LNP formulation and/or nucleic acid analytics is a plus.

Excellent organizational skills and ability to manage multiple projects or timelines simultaneously

Ability to adapt to increasing scope and complexity of work

Eagerness to be a critical contributor to a fast-moving team at a growing biotech startup

Candidates from underrepresented backgrounds are strongly encouraged to apply

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