Director / Associate Director - Oncology Safety Science & Discovery, Tumor Targeted Delivery

Found in: Jooble US O C2 - 2 weeks ago

Gaithersburg MD, United States AstraZeneca PLC Full time

Director / Associate Director - Oncology Safety Science & Discovery, Tumor Targeted Delivery
At AstraZeneca, it is our bold ambition is to eliminate cancer as a cause of death. This is underpinned by our rich pipeline aimed to deliver innovative treatment options for patients. Oncology Safety colleagues contribute to this ambition by accelerating innovative and expert non-clinical safety science.
We are looking to recruit a Director / Associate Director, Safety Science & Discovery to contribute to the discovery of novel targeted oncology medicines, including Antibody Drug Conjugates. In collaboration with scientists across our Oncology R&D organization, this role will develop investigative toxicology strategies to address drug target- and modality-related safety risks, drive progression of drug discovery programs, and develop our safety science to inform the design and selection of novel drug candidates. You will be able to develop your knowledge and skills by working together with experts and leaders in Oncology R&D, safety science, pharmacology, toxicology, drug discovery and development, imaging, pathology, and translational science.
As core member of multi-disciplinary drug discovery teams, you will direct investigative toxicology strategies to predict, assess and mitigate target- and modality-related safety risks in discovery programs, with a focus on Antibody-Drug Conjugates.
* Apply investigational and mechanistic safety studies through in vitro experimental capabilities to predict clinical safety and inform decision-making in drug discovery and development programs.
* Develop and implement innovative solutions and research proposals to pursue cutting edge science and technologies in line with business needs versus safety aspects.
* Maintain expertise in regulatory requirements and preclinical safety approaches applied to Antibody Drug Candidates and awareness of industry trends.
* Publish in high quality, peer-reviewed journals, present at internal scientific meetings and external conferences.
Excellent scientist with a PhD (or equivalent) in Biology, Toxicology, Pharmacology, Oncology, Immunology or related field, a strong scientific track record, and a willingness to challenge conventional thinking.
* A proven understanding of drug discovery and development, with a strong track record of independent research in industry, biotech, or academic setting.
* Expertise in Oncology and targeted therapeutics, including understanding of drug safety aspects of ADCs.
* The ability to build an understanding of biology around novel drug targets and pathways, develop testable hypotheses, and drive scientific learning.
* A collaborative, team-oriented approach, able to solve problems in a goal-focused fashion with capacity to coordinate tasks across multiple projects.
* Level of the role (Director / Associate Director) will be based on experience, understanding of drug discovery and development, and track record of successful contributions to progression of drug projects and scientific accomplishment.
In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. At AstraZeneca, we follow the science to explore and innovate. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference by fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be.
We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
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