Senior Director, Clinical Pharmacology

2 weeks ago


Redwood City CA, United States Revolution Medicines, Inc. Full time

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
We are seeking a highly motivated and energetic individual with relevant scientific background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization.
As a key member in Clinical Pharmacology and Pharmacometrics, you will:
* Provide strategic insight and technical leadership within the Clinical Pharmacology and Pharmacometrics
* Lead the design and execution of an integrated clinical pharmacology and modeling and simulation strategy to guide the clinical development plan.
* Apply state-of-the-art quantitative modeling, including population PK and exposure-response analyses, to guide dose/schedule optimization and recommended phase 2 dose/schedule (RP2Ds) selection.
* Ensure quality and integrity of modeling and simulations results.
* Author and provide technical input for regulatory documents and submissions related to all aspects of clinical pharmacology and pharmacometrics (including protocol, IB, briefing package, etc). Participate in regulatory interactions and responses to regulatory questions.
* Engage and work with consultants and/or CROs on clinical pharmacology and pharmacometrics activities to complement in-house knowledge/expertise and capacities.
* Represent the Clinical Pharmacology and Pharmacometrics function in project teams and build strong working relationships with cross-functional teams to impact critical decisions.
D. with 12+ years of clinical pharmacology and pharmacometrics or relevant industry experience.
* Demonstrated experience and track record in designing and executing clinical pharmacology and pharmacometrics components of clinical studies.
* Well-informed in current and emerging scientific standards of regulatory requirements and expectations.
* Strong interpersonal skills, and ability to influence development project and management teams.
* An individual's position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy.



  • Redwood City, CA, United States Revolution Medicines, Inc. Full time

    Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment...


  • Redwood City, United States Revolution Medicines, Inc. Full time

    Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment...


  • San Francisco, CA, United States EPM Scientific - Phaidon International Full time

    We are partnered with a growing precision medicine oncology biotechnology company based in San Francisco on an exciting Director/Senior Director opportunity! You will be providing guidance on all Clinical Pharmacology related programs such as authoring protocols, CSRs, data analysis, etc. A key role in this position is to provide PK/PD modeling and...


  • Redwood City, CA, United States Revolution Medicines, Inc. Full time

    Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination...


  • Redwood City, United States Revolution Medicines, Inc. Full time

    Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination...


  • San Francisco, CA, United States EPM Scientific - Phaidon International Full time

    We are partnered with a growing precision medicine oncology biotechnology company based in San Francisco on an exciting Director/Senior Director opportunity! You will be providing guidance on all Clinical Pharmacology related programs such as authoring protocols, CSRs, data analysis, etc. PhD in Pharmaceutical Sciences or a related field, or PharmD ~10...


  • San Diego, CA, United States Arrowhead Pharmaceuticals, Inc. Full time

    The Position Arrowhead Pharmaceuticals is seeking an experienced Clinical Pharmacologist to join our team. Responsibilities * Lead the function of Clinical Pharmacology/Pharmacometrics for multiple programs in Phase 1-3 development * Contribute to clinical protocols design and execution; analyze data and prepare clinical study reports * Participate in...


  • Jersey City, United States Noven Pharmaceuticals, Inc. Full time

    We are seeking an undergraduate or graduate student in life sciences who is interested in applying pharmacokinetics/pharmacodynamics and translational science in drug development.  This individual will work in our Clinical Pharmacology Department and will support the group in the decision-making for advancing molecules through critical stages of...


  • San Francisco, CA, United States EPM Scientific - Phaidon International Full time

    Join a dynamic, fast-paced biotechnology company based in South San Francisco dedicated to advancing oncology therapies! We are seeking a highly skilled and experienced Director/Senior Director of Pharmacometrics to contribute to the success of the company's drug development programs. Responsibilities: Develop and implement pharmacometrics...


  • Redwood City, United States Lassen Therapeutics Full time

    Director-Sr. Director Clinical OperationsLassen Therapeutics is a therapeutic antibody discovery and development company dedicated to the identification of novel medicines for serious unmet medical needs. We are currently recruiting an experienced and highly motivated Director-Sr. Director Clinical Operations to join us and provide hands-on management to...


  • Jersey City, NJ 07310, USA, United States Noven Pharmaceuticals, Inc. Full time

    We are seeking an undergraduate or graduate student in life sciences who is interested in applying pharmacokinetics/pharmacodynamics and translational science in drug development.  This individual will work in our Clinical Pharmacology Department and will support the group in the decision-making for advancing molecules through critical stages of...


  • Salt Lake City, United States University of Utah Full time

    Position Information Position/ Rank Faculty Member, Clinical Pharmacology / Rank Dependent on Qualifications Department 00945 - Peds Clinical Pharmacology City Salt Lake City, UT Track Track Dependent on Qualifications New Position to Begin CY 2023 D Clinical, Faculty, Clinic, Research, Healthcare, Program


  • Redwood City, CA, United States Adicet Bio Inc. Full time

    DIRECTOR /SENIOR DIRECTOR, TRANSLATIONAL MEDICINE Adicet Bio is seeking a Director/Senior Director of Translational Medicine to contribute to the successful translation of T cell-based products from Discovery Research to Clinical Development. The individual will define and implement preclinical and clinical translational and biomarker strategies for...

  • Senior Scientist

    4 days ago


    Redwood City, United States Adverum Biotechnologies, Inc. Full time

    Adverum is a clinical-stage AAV-based gene therapy company targeting unmet medical needs in ocular and rare diseases. We are seeking a highly motivated researcher to contribute to the development of innovative gene therapies in the nonclinical research group. The successful candidate will conduct internal and external nonclinical studies to generate proof of...


  • Redwood City, CA, United States Jasper Therapeutics Inc Full time

    Jasper is a biotechnology company focused on developing new therapies to treat both chronic and life threatening diseases. Our mission is to make safer and potentially curative therapy possible for more patients in need. We are bringing together a team of high performing biotech professionals, leading academic institutions and a strong syndicate of...

  • Senior Director

    3 weeks ago


    Redwood City, CA, United States Antiva Biosciences, Inc. Full time

    Senior Director / Vice President, Technical Operations Position Summary Antiva Biosciences, Inc. a well-funded venture-backed clinical stage biopharmaceutical company developing novel, topical therapeutics for the treatment of pre-cancerous lesions and infections caused by HPV, is seeking a Senior Director / Vice President, Technical Operations leader to...


  • Redwood City, CA, United States Moloco, Inc. Full time

    Director People Partner, you'll spearhead our mission to foster an inclusive and empowering workplace culture. Reporting directly to our Chief People Officer, you'll partner closely with senior leaders, particularly in Engineering, to craft and execute innovative People and culture strategies. Your role will be dynamic and impactful, encompassing talent...


  • South San Francisco, CA 94080, USA, United States ALX Oncology Holdings Inc. Full time

    ALX Oncology is a clinical-stage and patient-focused immuno-oncology company developing therapies that block the CD47 myeloid checkpoint pathway. Our lead candidate, evorpacept (ALX148), is a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated proprietary Fc domain. For more information about us,...


  • Redwood City, United States Bayside Solutions Full time

    What You' ll Do Serves as primary study team contact to manage the start-up, conduct and close-out of clinical studies. Leads the cross-functional study execution team to ensure that project milestones are met and adhere to approved budgets and are i Clinical, Senior, Clinic, Manager, Development, Process, Healthcare, Staffing


  • Redwood City, CA, United States Sumo Logic Full time

    Senior Director of Product Management Sumo Logic is a cloud-native SaaS data analytics platform that solves complex observability and security problems. Customers choose our product because it allows them to easily monitor, optimize, and secure their applications, systems, and infrastructures. Sumo Logic is seeking a product management leader who will...