Postdoc Research Fellow NEUROLOGY

Site: The Brigham and Women's Hospital, Inc.

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Courtesy posting

Job Summary

A postdoc position is open in the laboratory of Silke Nuber in the Ann Romney Center for Neurologic Diseases in the Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, to study alpha-synuclein biology in mice and cell culture models of Parkinson's disease (PD). The research focuses on determining whether gender or lipid-dependent changes that affect the alpha-synuclein tetramer:monomer ratio early in Parkinson's pathology confer neuroprotection to specific neurons and brain regions.

The PI's previous work demonstrated that upstream abrogation of normal -synuclein tetramers, the key protein in Lewy body pathology, induces a progressive, L-DOPA-responsive motor syndrome and cortical and dopaminergic fiber loss in familial PD E46K ("1K") and "3K" mutant mice. The new project uses these unique mouse models to study early-onset synucleinopathy. In addition, new models will be generated to analyze tetramer abrogation by other familial PD -synuclein mutations. Effects include behavioral testing as well as molecular, biochemical and neuropathological analyses.

Candidates must have extensive experience working with mice, including neonatal injections. Prior work with primary neurons and/or induced human neurons required. Only candidates with demonstrated expertise and publications in molecular biology, biochemistry, cell biology and animal husbandry should apply.

Qualifications

Requirements

• A Ph.D. in neuroscience, biochemistry or a related biological field.

• Excellent track record of publications, including in neurodegenerative disease.

• Extensive experience with mouse studies, including behavior, listed in detail in the CV.

• Experience in molecular biology, pathology and biochemistry, listed in detail in the CV.

• Cell culture (primary neurons and/or induced human neurons) experience preferred, listed in detail in the CV.

• Self-motivated and driven individual able to work both independently and in a team environment.

• Excellent oral and written communication skills in English.

• Minimum three-year commitment.

Compensation will follow NIH postdoctoral stipend levels. Applicants should submit a cover letter detailing their research experience, a CV, a potential start date, and full contact information for three reference to;

Dr. Silke Nuber )

Karen Tobin ( )

Additional Job Details (if applicable)

Remote Type

Onsite

Work Location

60 Fenwood Road

EEO Statement:

The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.