Principal In Vivo Cancer Research Scientist

1 week ago


New York, New York, United States Waypoint Bio Full time
Company Overview

Waypoint Bio is a venture-backed biotech startup that specializes in developing the next generation of cell therapies for solid tumors. Our cutting-edge platform combines spatial biology, pooled screening, in silico protein engineering, and machine learning to obtain both depth and breadth when screening cell therapy candidates – speed without compromising on in vivo accuracy.

About the Role

We are seeking an experienced part-time scientist to join our team. The ideal candidate will have expertise working with mouse cancer models (xenograft solid tumors) to test the efficacy and safety of cancer therapies. As a key member of our research team, you will optimize the performance of our existing solid tumor models and develop novel mouse models of solid tumors.

Key Responsibilities
  • Perform all steps of in vivo mouse studies to assess CAR T efficacy in CDX models, including subcutaneous injections for tumor implantation, measuring tumor growth over time, performing IV tail vein and intraperitoneal injections to deliver therapeutic agents, assessing humane & experimental endpoints in the mice, and harvesting tumors for subsequent ex vivo analysis.
  • Use mouse cancer models to apply Waypoint's pooled CAR-T screening platform in vivo.
  • Establish new in vivo cancer models and improve the performance and accuracy of existing models.
Requirements
  • Bachelor's degree in biology, immunology, genetics, cancer biology, or related field.
  • 2+ years of academic or industry experience working on mouse models of solid tumors.
  • Technical expertise in mouse injection methods (IV, SubQ, IP), subcutaneous tumor implantation and measurements, organ harvesting, animal phenotyping, and adherence to IACUC protocols.
  • Experience with mammalian cell culture.
  • Detailed scientific record keeping in electronic format.
  • An excellent scientific track record with published papers or recent experience in the fields of cancer biology or immunotherapy.
Estimated Salary

$85,000 - $110,000 per year, based on qualifications and location.



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