Senior Research Scientist
2 weeks ago
About the Role:
We are seeking a highly skilled Senior Research Scientist to join our R&D team at the Coriell Institute for Medical Research. As a key member of our team, you will play a critical role in advancing our mission to innovate in the areas of stem cell research, genome editing, and supporting the Camden Cancer Research Center (CCRC) biobank.
Key Responsibilities:
* Lead and support research technicians by overseeing day-to-day laboratory activities, mentoring team members, and ensuring adherence to safety and quality protocols.
* Reprogram primary human cell lines into iPSCs, ensuring adherence to best practices and high-quality standards.
* Perform routine maintenance, expansion, and cryopreservation of various human cell lines, documenting cell culture processes and ensuring traceability.
* Characterize iPSC and differentiated cell lines using techniques such as immunohistochemistry, flow cytometry, and qPCR, ensuring consistency and reproducibility in experimental data.
* Plan, execute, and analyze flow cytometry experiments to characterize cell surface markers and evaluate the quality and purity of iPSCs and differentiated cell types.
* Execute precise CRISPR-Cas9 protocols for genome modification, contributing to the creation of isogenic cell lines.
* Maintain detailed, accurate, and up-to-date laboratory records, ensuring all data are traceable and can be used in future projects and publications.
Qualifications:
* Master's or Ph.D. degree in Cell/Molecular Biology, Biotechnology, or a related field.
* Minimum of 5 years of hands-on experience with iPSCs and human cell lines.
* Proficiency in aseptic cell culture techniques and ability to troubleshoot and optimize protocols.
* Expertise in molecular and cell biology techniques, including ELISA, qPCR, DNA/RNA isolation, immunohistochemistry, and flow cytometry.
* Strong working knowledge of CRISPR-Cas9 genome editing with proven ability to validate and troubleshoot experiments.
About Coriell:
The Coriell Institute for Medical Research is a nonprofit research institute dedicated to improving human health through biomedical research. Coriell scientists lead research in personalized medicine, cancer biology, epigenetics, and the genomics of opioid use disorder. Coriell also hosts one of the world's leading biobanks—comprised of collections for the National Institutes of Health, disease foundations and private clients—and distributes biological samples and offers research and biobanking services to scientists around the globe.
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