Associate Engineer II, LNP Process Development Specialist

4 weeks ago

Menlo Park, California, United States ReCode Therapeutics, Inc Full time
About ReCode Therapeutics, Inc

ReCode Therapeutics, Inc is a clinical-stage genetic medicines company leveraging precision delivery to power the next wave of mRNA and gene correction therapeutics.

Our proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues, and cells implicated in disease, enabling improved efficacy and potency.

Job Summary

The Associate Engineer will work as part of a team, under the direction of the group leader/manager, to conduct laboratory experiments to support the development of robust scalable LNP-encapsulated nucleic acids formulations and manufacturing processes, including lab-scale process development, process scaleup, and in-process characterization.

Key Responsibilities
  • Execute studies to define formulation components, vehicle, and primary container.
  • Operate common biopharmaceutical unit operations such as mixing, dialysis, tangential flow filtration, and sterile filtration.
  • Support efforts in fill/finish process optimization, process characterization, technology transfer, and regulatory documentation for our LNP formulations candidates.
  • Interface with External Manufacturing, Quality, and Regulatory organizations to execute on strategies for GLP or GMP batches.
  • Perform in-process characterization such as pH, particle size, encapsulation efficiency measurement, etc.
  • Manage daily pre-formulation/material assessments of LNP screening and development.
  • Support troubleshooting and technical investigations as needed.
  • Responsible for executing or supporting experiments to meet agreed-upon deliverables and timelines.
  • Optimize existing formulation methods and processes and generate standard operating procedures (SOPs) and test method documents.
  • Maintain thorough and detailed electronic lab notebooks and documentation records.
  • Support and participate in R&D and project management meetings. Prepare PowerPoint slides and present findings to multi-disciplinary teams.
  • Adhere to all laboratory safety requirements and procedures.
  • Assist in maintaining general laboratory functionality and lab equipment.
  • Assist in ordering and receiving of lab supplies.
  • Exercise judgment within defined procedures and practices to determine appropriate action.
Requirements
  • B.S. or M.S. in chemical engineering, bioengineering, pharmaceutical sciences, or related field.
  • Foundation in chemistry, materials science, bio-engineering, chemical engineering, or related field.
  • Strong written and oral communication skills, comfort with a 'start-up environment.'
  • Familiarity with CAD software such as Solidworks AutoCAD is an advantage.
Benefits

No premium cost for employees - 100% subsidized by ReCode for full-time employees.

Company 401k contribution.

15 days of company-paid holidays, including a holiday shutdown (usually the last week of the year).

Mental health support for employees & their families.

FSA available, including a lifestyle spending account subsidized by company.

Employee discounts at hotspots.

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