Senior Stem Cell Researcher

3 weeks ago


Étreux, Hauts-de-France, United States Ovelle Full time

About Ovelle:

Ovelle is a pioneering research-first startup dedicated to revolutionizing fertility treatment through human in vitro oogenesis. Our innovative approach involves directed differentiation of human iPSCs to ovarian cell types, including granulosa cells and oogonia, by manipulating expression of transcription factors and RNA-binding proteins. This groundbreaking technology has the potential to make fertility treatments more accessible and affordable, marking a paradigm shift in treatments for infertility.

About the Role:

We are seeking a highly skilled Stem Cell Scientist to lead our efforts in developing and optimizing protocols for deriving granulosa cells and other supporting ovarian cells from human iPSCs. This critical role is essential to the success of human in vitro oogenesis. The successful candidate will have the opportunity to apply their expertise in a field with immense potential to impact global health and happiness.

Key Responsibilities:

  • Lead the optimization and execution of the directed differentiation protocol to generate functional ovarian supporting cells from human iPSCs.
  • Design and implement transcription factor screening experiments to identify key regulators of ovarian cell fate.
  • Develop and characterize 3D ovarian organoids (ovaroids) by co-culturing iPSC-derived granulosa-like cells with meiotic oogonia.
  • Collaborate with our bioinformatics team to interpret bulk and single-cell RNA sequencing data, contributing to the understanding of ovarian cell development and function.

Requirements:

  • Ph.D. in Biology, Biochemistry, or a closely related field; or a track record of innovation.
  • Experience working with human pluripotent stem cells and directed differentiation protocols.
  • Proficiency in genetic engineering techniques, including plasmid design and cloning, CRISPR/Cas9-mediated genome editing, lentiviral/transposon-based gene delivery systems, and pooled library screens.
  • Experience with flow cytometry, fluorescence-activated cell sorting (FACS), and immunofluorescence microscopy, including experimental design and data analysis.
  • Familiarity with sequencing technologies, particularly single-cell RNA-seq, and basic bioinformatics skills for data analysis.
  • Proven track record of successful execution of complex, multi-step cell culture protocols and 3D organoid systems.

Why Ovelle:

Ovelle is a research-first startup where scientists work together on a single, deep, and important problem: IVG. We operate like a fast, efficient academic lab without constraints. We're committed to sharing our work with the scientific community and welcome collaborations with academic researchers. Our people are the heart of our success, and our compensation and benefits reflect this. We believe in encouraging inclusion, acceptance, and understanding by employing individuals who bring unique perspectives to the company.

Benefits:

  • 12.5 paid holidays
  • 20 days PTO
  • Up to 12 weeks paid leave for new parents who are primary caregivers
  • Perq MBTA pass program
  • Medical, Dental, and Vision
  • Matching 401(k) plan
  • Tuition reimbursement for work-related continuing education.


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