Scientific Leader for HIV Treatment and Prevention

4 weeks ago


Branford, Connecticut, United States ViiV Healthcare Full time
Scientific Leader Job Description

ViiV Healthcare is seeking a highly skilled Scientific Leader to join our Discovery DMPK team in Branford, CT. As a key member of our team, you will be responsible for driving the DMPK strategy for multiple Drug Discovery stage projects from early lead optimization through Phase I clinical studies.

Key Responsibilities:
  • Develop and implement DMPK strategies for assigned projects, ensuring translational PKPD approaches and appropriate screening cascades with multi-parametric optimization.
  • Design and conduct bespoke mechanism-based studies to address program needs, utilizing your extensive laboratory experience.
  • Efficiently manage your time and project requests for DMPK work to ensure optimal support of projects across different modalities in the ViiV Discovery pipeline.
  • Coordinate and deliver high-quality DMPK written contributions to technical and regulatory documents.
  • Develop and maintain excellent working relations with stakeholders in Discovery project teams, ensuring strategic alignment.
  • Actively support cross-DMPK initiatives as a representative from the ViiV Nonclinical Safety and DMPK team to drive DMPK science and operations.
Requirements:
  • MS Degree (7 years' experience) or PhD (>2 years' experience post-graduation) in a field relevant to DMPK (e.g., Pharmacology, Biochemistry, Pharmacokinetics or Drug Metabolism).
  • Experience state-of-the-art DMPK science in projects to enable the discovery of new medicines, including experience with small molecules and biologics drug discovery and/or development.
  • Experience managing DMPK related project resources and budgets.
  • Experience working in cross-matrix teams, with demonstrated experience in project milestone delivery.
Preferred Qualifications:
  • PhD in a field relevant to DMPK (e.g., Pharmacology, Biochemistry, Pharmacokinetics or Drug Metabolism) with >5 years drug discovery experience.
  • In-depth experience in DMPK representation in Discovery projects across different modalities (e.g., small molecule, mAb, long-acting injectable) and has strong experience in human dose prediction.
  • Examples demonstrating the successful selection of drug candidates through efficient ADME screening cascades such as multi-parametric optimization, translational PKPD and human dose optimization strategies.
  • Experience in leveraging modeling approaches and predictive science in Discovery projects to accelerate timelines and increase probability of success.
  • Excellent communication/written skills and collaboration as demonstrated through publication and/or external interactions (e.g., university collaborations, speaking invitations etc.).


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