Biophysics Scientist
7 days ago
ROLE SUMMARY
We are seeking a skilled Biophysics Scientist to join our Biophysics & HTS group within Discovery Technologies at Pfizer's Oncology Research Unit in La Jolla. As a discipline expert, you will characterize small molecule-protein interactions using biophysical methods (SPR, HTRF, ITC, thermal stability-based assays, MST, native MS). Your role will be pivotal in providing scientific insights into the kinetics and thermodynamics of protein-ligand interactions to impact project teams.
JOB RESPONSIBILITIES
- Evaluate drug interactions and protein behavior primarily using biophysical methods, including SPR, HTRF, ITC, MST, and native MS.
- Represent the biophysics group on multi-disciplinary teams to provide scientific expertise and strategic insights.
- Develop and apply emerging biophysical technologies to strengthen current capabilities within the group.
- Mentor and train colleagues in biophysical methods and techniques.
REQUIRED QUALIFICATIONS
- PhD degree in Biophysics, Biochemistry, Structural Biology or a closely related field with 3-5 years of experience in drug discovery.
- Demonstrated expertise in biophysical methods for characterizing protein-ligand interactions.
- Hands-on experience in high-throughput screening and plate-based pharmacology.
- Experience handling diverse recombinant proteins as tools in biochemical or biophysical assays.
- Knowledge of enzymology, mechanisms of drug action, and structural biology.
SALARY AND BENEFITS
The annual base salary for this position is estimated at $122,700. In addition to the base salary, this role is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15% of the base salary and eligibility to participate in our share-based long-term incentive program. Comprehensive benefits include health benefits, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and a 401(k) plan with Pfizer Matching Contributions.
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