Biophysics Scientist

7 days ago


San Diego, California, United States Pfizer Full time

ROLE SUMMARY

We are seeking a skilled Biophysics Scientist to join our Biophysics & HTS group within Discovery Technologies at Pfizer's Oncology Research Unit in La Jolla. As a discipline expert, you will characterize small molecule-protein interactions using biophysical methods (SPR, HTRF, ITC, thermal stability-based assays, MST, native MS). Your role will be pivotal in providing scientific insights into the kinetics and thermodynamics of protein-ligand interactions to impact project teams.

JOB RESPONSIBILITIES

  1. Evaluate drug interactions and protein behavior primarily using biophysical methods, including SPR, HTRF, ITC, MST, and native MS.
  2. Represent the biophysics group on multi-disciplinary teams to provide scientific expertise and strategic insights.
  3. Develop and apply emerging biophysical technologies to strengthen current capabilities within the group.
  4. Mentor and train colleagues in biophysical methods and techniques.

REQUIRED QUALIFICATIONS

  • PhD degree in Biophysics, Biochemistry, Structural Biology or a closely related field with 3-5 years of experience in drug discovery.
  • Demonstrated expertise in biophysical methods for characterizing protein-ligand interactions.
  • Hands-on experience in high-throughput screening and plate-based pharmacology.
  • Experience handling diverse recombinant proteins as tools in biochemical or biophysical assays.
  • Knowledge of enzymology, mechanisms of drug action, and structural biology.

SALARY AND BENEFITS

The annual base salary for this position is estimated at $122,700. In addition to the base salary, this role is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15% of the base salary and eligibility to participate in our share-based long-term incentive program. Comprehensive benefits include health benefits, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and a 401(k) plan with Pfizer Matching Contributions.



  • San Diego, California, United States Tektonyx Bio, Inc. Full time

    Tektonyx Bio, Inc. is a pioneering biotechnology company leveraging semi-synthetic E. coli to revolutionize protein therapeutics production.We are seeking an analytical scientist with expertise in mass spectrometry to develop novel methods for characterizing proteins and optimizing unnatural protein production.The successful candidate will work closely with...

  • Protein Scientist

    5 days ago


    San Diego, California, United States Vertex Pharmaceuticals Full time

    Vertex Pharmaceuticals is seeking an experienced scientist to lead Protein Expression and Purification efforts, utilizing expertise in molecular biology and protein chemistry techniques. Key responsibilities include designing and implementing protein purification protocols, troubleshooting expression and purification of challenging targets, and...

  • Research Scientist

    1 week ago


    San Diego, California, United States Scripps Research Full time

    About UsScripps Research is a leading biomedical institute with a century-long legacy of innovative discoveries. Located in La Jolla, California, our institution houses six research departments, multiple Nobel laureates, and a top-ranked graduate school.We collaborate with researchers from the Scripps Research Translational Institute and Calibr to merge...

  • Protein Scientist

    7 days ago


    San Francisco, California, United States TBWA\Chiat\Day Full time

    About the RoleWe are seeking a highly motivated Protein Scientist to join our team at EvolutionaryScale in San Francisco. As an Associate Scientist - Protein Sciences, you will play a key role in advancing protein design using artificial intelligence and contribute to groundbreaking discoveries in the field.Key ResponsibilitiesPerform molecular biology...


  • South San Francisco, California, United States Aequor Technologies Full time

    We are seeking a highly motivated Senior Data Scientist to join our team at Aequor Technologies. The ideal candidate will have expertise in machine learning and computational chemistry, with a strong background in analytical chemistry.Job SummaryThe Senior Data Scientist will be responsible for developing and deploying machine learning and computational...


  • San Carlos, California, United States Meet Full time

    Job ResponsibilitiesDevelop, implement, and oversee analytical methods for drug product characterizationLead and manage a team of junior-level scientists across various projectsEvaluate biophysical and biochemical characterization tools to support vaccine developmentThe successful candidate will have a PhD in Biochemistry, Chemistry, or Biophysics, or a...


  • San Francisco, California, United States Next Level Talent, LLC Full time

    Drive Climate-Focused InnovationWe are a VC-backed startup pushing the boundaries of science to address critical climate challenges. Our mission is to create scalable, carbon-negative polymer production using genetically engineered bacteria and enzymatic processes.About the Role:As a Senior Research Scientist, you will play a key role in driving our...


  • San Francisco, California, United States Software Guidance & Assistance, Inc. (SGA, Inc.) Full time

    About Software Guidance & Assistance, Inc.Software Guidance & Assistance, Inc. (SGA, Inc.) is a women-owned business that provides technology and resource solutions to tackle big IT problems with a personal approach. Our mission is to stand out by solving complex challenges through a boutique service.About the JobWe are seeking a highly motivated Data...


  • South San Francisco, California, United States Talent Software Services Full time

    Company Overview:Talent Software Services is a leading provider of contract staffing solutions, offering expertise in machine learning and computational chemistry. Our team works with clients across various industries to deliver innovative solutions.Salary:We are offering a competitive salary range of $140,000 - $170,000 per annum, commensurate with...


  • San Francisco, California, United States Next Level Talent, LLC Full time

    About the RoleAs a key member of our research team, you will drive cutting-edge R&D initiatives in bioprocessing and structural biology. Collaborate with experts from various fields to develop high-quality data for machine learning models, automate data generation processes using microfluidics, and explore innovative methods for enzyme functional...


  • San Francisco, California, United States Meet Full time

    Meet, an innovative biotech company in San Mateo County, is seeking a highly skilled Group Leader to oversee analytical method development for drug product characterization. As a key member of our team, you will directly manage junior-level scientists and contribute to the growth of our organization.About MeetMeet is a well-funded biotech organization...


  • San Francisco, California, United States Aequor Full time

    About Aequor">Aquatic Technologies Corp, operating under the brand name Aequor, is a pioneer in computational chemistry research. Our mission is to push the boundaries of knowledge and innovation through cutting-edge scientific advancements.">Salary Information">The compensation package for this position includes an estimated annual salary of...


  • San Francisco, California, United States TBWA\Chiat\Day Full time

    About UsEvolutionaryScale, a pioneer in harnessing artificial intelligence to unlock the complexities of biology, is revolutionizing human health and society. Our mission is to push the boundaries of what AI can achieve in biological discovery, transforming the design of biological systems, enabling programmable molecules and cells.We prioritize individuals...


  • San Diego, California, United States Bristol Myers Squibb Full time

    Expertise in Protein Production and QualityYou will join the Discovery Biotherapeutics team at Bristol Myers Squibb, where you will play a crucial role in supporting the delivery of a first-in-class and best-in-class biotherapeutics pipeline. As a member of our team, you will lead a team of scientists across two BMS sites located in San Diego (CA) and...


  • San Diego, California, United States Light Horse Therapeutics Full time

    Company Overview:Light Horse Therapeutics is a pioneering drug discovery company based in San Diego, utilizing cutting-edge tools from chemical and computational biology to identify novel targets for therapeutic intervention in oncology.The company was founded by renowned academics Brian Liau (Harvard), Ben Cravatt (Scripps) and Nathanael Gray (Stanford)...


  • South San Francisco, California, United States Lyterian Full time

    OverviewAt Lyterian Therapeutics, we are dedicated to creating innovative medicines for patients in need. Our approach is centered around harnessing protein homeostatic mechanisms to regulate genetically-validated targets.Job SummaryWe are seeking a highly experienced Scientific Leader of Structural Biology and Protein Research to join our team. This role...

  • Protein Biochemist

    6 days ago


    San Francisco, California, United States Skills Alliance Full time

    About the RoleWe are seeking an accomplished Senior Research Scientist to join our team at Skills Alliance. As a key member of our protein engineering group, you will contribute to the advancement of our genetic medicine technologies and play a pivotal role in the discovery and development of new therapeutics.Key ResponsibilitiesIndependently develop novel...


  • South San Francisco, California, United States Talent Software Services Full time

    **Job Summary:**Talent Software Services is seeking a highly skilled Artificial Intelligence and Computational Chemistry Researcher for a contract position in South San Francisco, CA.The opportunity will be one year with a strong chance for a long-term extension. Our client is looking for a talented researcher to drive research and engineering efforts to...


  • San Francisco, California, United States R&D Partners Full time

    Unlock the Power of Mass-Spectrometry DataR&D Partners is seeking a highly skilled Analytical Chemistry Platform Engineer to drive research and engineering efforts in developing mass-spectrometry data platforms for drug discovery.About the RoleThis 12-month contract position involves extensive collaboration with computational and experimental scientists to...

  • Principal Scientist

    3 weeks ago


    San Diego, United States Pfizer Full time

    Principal Scientist (PhD), Biophysics ROLE SUMMARY The Pfizer Oncology Research Unit in La Jolla is seeking an accomplished Principal Scientist to join the Biophysics & HTS group within Discovery Technologies. The successful candidate will evaluate drug interactions and protein behavior primarily using biophysical methods. In addition, the characterization...

  • Principal Scientist

    3 weeks ago


    San Diego, United States Pfizer Full time

    ROLE SUMMARY The Pfizer Oncology Research Unit in La Jolla is seeking an accomplished Principal Scientist to join the Biophysics & HTS group within Discovery Technologies. The successful candidate will evaluate drug interactions and protein behavior primarily using biophysical methods. In addition, the characterization of drug interactions may involve other...

  • Senior Scientist

    2 days ago


    San Diego, CA, United States Pfizer Full time

    Senior Scientist (PhD), Biophysics Apply locations: United States - California - La Jolla time type: Full time posted on: Posted 2 Days Ago job requisition id: 4922236 ROLE SUMMARY The Pfizer Oncology Research Unit in La Jolla is seeking a Senior Scientist to join the Biophysics & HTS group in Discovery Technologies. The successful candidate will evaluate...

  • Principal Scientist

    2 days ago


    San Diego, CA, United States Pfizer Full time

    Principal Scientist (PhD), Biophysics ROLE SUMMARY The Pfizer Oncology Research Unit in La Jolla is seeking an accomplished Principal Scientist to join the Biophysics & HTS group within Discovery Technologies. The successful candidate will evaluate drug interactions and protein behavior primarily using biophysical methods. In addition, the characterization...

  • Scientist II

    4 weeks ago


    san diego, United States Net2Source Inc. Full time

    Job Title: Scientist – IIDuration: 12 monthsLocation: 3050 Science Park Road, San Diego, CA 92121 Pay Rate: $ 34.76/hr on W2 Qualifications:Education:• Bachelor’s Degree with 1 years of academic or industry experience• Minimum 1-3yrs experience preferred Required Skills• Contribute to lab administration and organization through ordering, managing...

  • Scientist II

    1 month ago


    San Diego, United States Net2Source Inc. Full time

    Job Title: Scientist – IIDuration: 12 monthsLocation: 3050 Science Park Road, San Diego, CA 92121 Pay Rate: $ 34.76/hr on W2 Qualifications:Education:• Bachelor’s Degree with 1 years of academic or industry experience• Minimum 1-3yrs experience preferred Required Skills• Contribute to lab administration and organization through ordering, managing...

  • Senior Scientist

    4 weeks ago


    San Diego, United States Net2Source Inc. Full time

    Job Title: Scientist - III (Senior) - CA OnlyDuration: 12 monthsLocation: 3050 Science Park Road, San Diego, CA 92121 Pay Range: $40 - $ 47/hr. on W2Job ID: 36504Qualifications:Education:• Bachelor’s Degree with minimum 3 years of academic or industry experienceRequired Skills• Contribute to lab administration and organization through ordering,...

  • Senior Scientist

    3 weeks ago


    san diego, United States Net2Source Inc. Full time

    Job Title: Scientist - III (Senior) - CA OnlyDuration: 12 monthsLocation: 3050 Science Park Road, San Diego, CA 92121 Pay Range: $40 - $ 47/hr. on W2Job ID: 36504Qualifications:Education:• Bachelor’s Degree with minimum 3 years of academic or industry experienceRequired Skills• Contribute to lab administration and organization through ordering,...

  • Senior Scientist

    4 weeks ago


    san diego, United States Net2Source Inc. Full time

    Job Title: Scientist - III (Senior) - CA OnlyDuration: 12 monthsLocation: 3050 Science Park Road, San Diego, CA 92121 Pay Range: $40 - $ 47/hr. on W2Job ID: 36504Qualifications:Education:• Bachelor’s Degree with minimum 3 years of academic or industry experienceRequired Skills• Contribute to lab administration and organization through ordering,...


  • San Diego, United States eTeam Full time

    Job Title: Scientist - II (Associate)Location: San Diego, CADuration: 12 months’Pay Rate: $35/hrResponsibilities:As a Research Scientist, you will play an important role in our growing team, supporting research needs as well as laboratory organization. This position offers a great opportunity to be a part of the early scientific team building different...


  • san diego, United States eTeam Full time

    Job Title: Scientist - II (Associate)Location: San Diego, CADuration: 12 months’Pay Rate: $35/hrResponsibilities:As a Research Scientist, you will play an important role in our growing team, supporting research needs as well as laboratory organization. This position offers a great opportunity to be a part of the early scientific team building different...

  • Scientist II

    4 weeks ago


    san diego, United States Pyramid Consulting, Inc Full time

    Immediate need for a talented Scientist II. This is a 05+ Months Contract opportunity with long-term potential and is located in San Diego, CA (Onsite). Please review the job description below and contact me ASAP if you are interested.Job ID:24-48953Pay Range: $30 - $35/hour. Employee benefits include, but are not limited to, health insurance (medical,...

  • Scientist II

    1 month ago


    San Diego, United States Pyramid Consulting, Inc Full time

    Immediate need for a talented Scientist II. This is a 05+ Months Contract opportunity with long-term potential and is located in San Diego, CA (Onsite). Please review the job description below and contact me ASAP if you are interested.Job ID:24-48953Pay Range: $30 - $35/hour. Employee benefits include, but are not limited to, health insurance (medical,...


  • san francisco, United States Skills Alliance Full time

    About the Role: As a Protein Biochemistry Senior Scientist, you will advance our genetic medicine technologies, enabling the discovery and development of new therapeutics. Working with a diverse team of cell biologists, protein and RNA engineers, computational scientists, molecular biologists, and translational biologists, you will:• Independently...


  • san francisco, United States Skills Alliance Full time

    About the Role: As a Protein Biochemistry Senior Scientist, you will advance our genetic medicine technologies, enabling the discovery and development of new therapeutics. Working with a diverse team of cell biologists, protein and RNA engineers, computational scientists, molecular biologists, and translational biologists, you will:• Independently...


  • South San Francisco, United States Skills Alliance Full time

    About the Role: As a Protein Biochemistry Senior Scientist, you will advance our genetic medicine technologies, enabling the discovery and development of new therapeutics. Working with a diverse team of cell biologists, protein and RNA engineers, computational scientists, molecular biologists, and translational biologists, you will:• Independently...

  • Medicinal Chemistry

    4 weeks ago


    San Diego, United States Society of Exploration Geophysicists Full time

    Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...

  • Scientist II

    4 weeks ago


    San Diego, CA, United States Pyramid Consulting, Inc Full time

    Immediate need for a talented Scientist II. This is a 05+ Months Contract opportunity with long-term potential and is located in San Diego, CA (Onsite). Please review the job description below and contact me ASAP if you are interested.Job ID:24-48953Pay Range: $30 - $35/hour. Employee benefits include, but are not limited to, health insurance (medical,...

  • Medicinal Chemistry

    1 month ago


    San Diego, United States Light Horse Therapeutics Full time

    Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...

  • Medicinal Chemistry

    1 month ago


    san diego, United States Light Horse Therapeutics Full time

    Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...