Senior Pharmacologist for Cell Engager Therapies

1 week ago


Étreux, Hauts-de-France, United States Takeda Pharmaceuticals Full time

We are seeking a talented Senior Research Associate, Cell Engager Therapies In Vivo Pharmacologist to join our dynamic team at Takeda Pharmaceuticals. In this role, you will be responsible for the discovery and development of novel therapeutics in the T cell engager space, supporting new and ongoing pipeline programs.

About the Job:

As a key member of our team, you will be responsible for new in vivo model development, target validation, assessing therapeutic concepts of various immune engager molecules, and advancing development candidates to IND. You will collaborate and demonstrate effective communication and documentation of results.

Main Responsibilities:
  • Develop animal models to test the biological efficacy of therapeutic agents for oncology indications.
  • Design and execute in vivo efficacy models in xenograft and PDX models.
  • Participate in analysis of in vivo studies to help establish PK / PD / efficacy relationships.
  • Execute experiments with minimum supervision and deliver comprehensive high-quality data sets to enable decision-making.
  • Ability to multi-task effectively and prioritize workload.
  • Interpret results of complex experiments.
  • Prepare and present comprehensive technical or project reports and formal presentations.
  • Maintain laboratory notebooks and follow laboratory practices in compliance.
Requirements:
  • MS with 1+ years' experience, or BS with 3+ years' of research experience in a lab setting working with animals.
  • Experience in industry required, in animal facilities.
  • Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft, and PDX models.
  • Experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, PO, RO), and blood/tissue collection.
  • Experience culturing and maintaining human tumor cell lines and primary human cells, preferably T cells, with best practices in tissue culture.
  • Hands-on basic experience with multi-color flow cytometry, ELISA, MSD, and other standard cell-based and non-cell-based biochemical assays.
  • Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo, etc.).
  • Excellent team player with a can-do attitude with an ability to thrive in a dynamic environment and work in cross-functional project teams.
  • Self-motivated, collaborative with excellent time management and organizational skills.


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