Senior Bioinformatics Engineer

2 weeks ago


New York, New York, United States Simons Foundation Full time
Job Title: Senior Bioinformatics Engineer

The Simons Foundation is seeking a highly skilled Senior Bioinformatics Engineer to join our team. As a key member of our Bioinformatics team, you will play a critical role in returning genetic results to thousands of SPARK participants, including ASD and secondary health-related variants.

Key Responsibilities:
  • Manage the bioinformatics portion of the return of genetic results process, including delivery of sequencing data, variant analysis, and clinical validation orders
  • Track data deliveries of samples sent for sequencing
  • Run quality control pipeline to confirm RoR eligibility
  • Run variant filtering and annotation pipelines for SNVs/Indels & CNVs
  • Coordinate lab confirmation orders for predicted pathogenic variants
  • Analyze and summarize statistics for sequencing batches
  • Respond to questions from SPARK or lab related to variant predictions/orders
Requirements:
  • Master's degree in bioinformatics, computational biology, or related field
  • At least 4+ years of relevant work experience
  • Strong Python skills and software development best practices
  • Experience with sequencing data (whole exome or whole genome) and related tools
  • Experience performing reproducible data analysis
  • Experience working in an HPC environment
  • Experience with git/github
  • Effective oral and written communicator
  • Ability to thrive in collaborative environments
Preferred Qualifications:
  • Ph.D. in bioinformatics, computational biology, or related field
  • Project management experience
  • Experience analyzing large research datasets (>10,000 individuals)
  • Familiarity with core genetics concepts
  • Solid understanding of statistical analysis
  • Experience generating interactive data visualizations or dashboards
What We Offer:
  • Competitive salary range: $150,000 - $175,000
  • Outstanding benefits package

The Simons Foundation is an equal opportunity employer and welcomes applications from diverse candidates. We are committed to creating an inclusive work environment that values diversity, equity, and inclusion.



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