Clinical Data Analyst for Precision Oncology
7 days ago
Revolution Medicines is a clinical-stage precision oncology company dedicated to developing innovative targeted therapies that inhibit frontier targets in RAS-addicted cancers. Our research and development pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies.
Salary Range: $120,000 - $158,000This full-time position offers a highly competitive salary range, with the base salary being one part of the overall total rewards program at RevMed. The total rewards package includes robust equity awards, strong benefits, and significant learning and development opportunities.
Job Description: Clinical Data AnalystIn this role, you will work within our Translational Medicine group analyzing and interpreting molecular and clinical data. Your analysis will focus on using genomic, protein, and other targeted assays to identify and validate predictive biomarkers.
- You will integrate multiple data sources, including circulating tumor DNA, patient enrollment data, molecular profiling (RNA/DNA sequencing outputs), and multiplex immunohistochemistry to identify and validate new biomarkers for candidate drugs.
- Work with internal groups, contract research organizations, and collaborators to deliver validated biomarker data and analysis.
- Support the development of biomarker-related aspects of the trial design where bioinformatic analysis is required, including study protocols, lab manuals, clinical study reports, and other regulatory documents.
- Collaborate with biomarker scientists to support analysis of biomarker readouts, including summary statistics and visualization of efficacy in molecular subgroups.
- Work with preclinical bioinformaticians to design, analyze, and interpret experiments to validate biomarkers, understand compound mechanism of action, and identify biomarkers for patient selection and target engagement.
- A MS or Ph.D. in bioinformatics, biology, data science, or a related field with an emphasis on biological data analysis.
- At least 2 years of experience in pharmaceutical or biotech companies focused on oncology, immunology, or a related field.
- Proficiency and experience programming using R and/or Python.
- Proficiency in statistical models and analysis of clinical data. Some ML experience is a strong plus.
- Experience with visualizations and faceting of molecular data, including oncoplots, heatmaps, PCA, etc.
- Experience with efficacy, baseline demographic, and other outcome data generated in a clinical trial.
- Experience with statistical methods such as survival analysis and causal inference.
- Expertise in bioinformatic analysis of cancer signaling pathways and driver mutations.
- Experience working with tools to analyze cancer genomics data types, such as RNA, WES, ctDNA, etc., and common tool outputs, such as GATK, Salmon, OncoKB, VEP, etc.
Revolution Medicines is an equal opportunity employer that prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Location and Work EnvironmentThe successful candidate will be based at our headquarters in Redwood City, CA, and will have access to state-of-the-art facilities and equipment.
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