Muscle Regeneration Research Scientist

5 days ago


Cambridge, Massachusetts, United States Harvard University Full time
Research Opportunity

A research position is available in the Rubin Lab at Harvard University to investigate skeletal muscle regeneration and satellite cell biology. Our laboratory focuses on studying complex molecular pathways underlying different disease states, especially late onset neurodegenerative disorders and neuromuscular diseases, with a goal of identifying novel therapeutic avenues.

We are currently evaluating whether defects in satellite cells may contribute to neuromuscular diseases using primary patient-derived cells (iPSCs, myogenic progenitors), genetic mouse models, and phenotypic drug screening methods. In addition, we are examining severe muscle damage that results in a less efficient regenerative process. Studies will range from muscle functional assays (quantification of muscle force), isolation and culture of satellite cells, and the mechanistic study of pathways required to confer satellite cell regenerative capacity.

This position requires a Ph.D. in satellite cell biology, developmental biology or cell/molecular biology. The ideal candidate should have some familiarity with cell culture, FACS, transcriptional or epigenetic profiling along with mouse husbandry and knowledge of skeletal muscle functional assays. A demonstrated record of research achievement, strong written and oral communication skills, and ability to work independently are also essential qualifications.

The selected applicant will receive a salary around $70,000-$90,000 per year, depending on experience, and will be responsible for submitting a cover letter, CV, a brief research proposal, and two to three references' names and contact information to Dr. Lee Rubin. Selected applicants will be further interviewed by zoom.

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