Senior Mechanical Engineer

4 weeks ago

Redwood City, California, United States Synthego Full time

Synthetic genome engineering company Synthego is seeking a seasoned mechanical engineer to lead its growing Hardware division.

This role would involve acting as a subject matter expert on liquid handling methodologies and leading Synthego's custom technology development, including upgrading existing internal hardware systems and guiding architectural decisions for future hardware projects and platforms.

The successful candidate will manage and mentor an expanding team of mechanical engineers and work closely with development and operations teams in chemistry, software, and manufacturing.

This is a career opportunity to develop leadership skills and design, build, and improve production instrumentation for gene editing reagent manufacturing.

Key Responsibilities:

  • Perform conceptual, architectural, and detailed mechanical design of novel instruments and instrument subsystems
  • Contribute to design reviews for subsystem and component level designs, utilizing experience to provide guidance to technical staff
  • Guide architectural level decisions on hardware projects and platforms, incorporating user requirements, multi-disciplinary knowledge, and strategic thinking
  • Devise and implement strategies for continuous improvement of existing legacy equipment
  • Manage mechanical system and hardware development activities while communicating timelines, budgets, and technical decision making to leadership teams
  • Develop and maintain engineering processes and best practices, working across functional groups (such as Software, Data Science, Chemistry, and Operations) where necessary to improve the quality of the engineering product, and remove roadblocks for staff
  • Mentor a direct report as well as new hardware hires, while prioritizing the team's professional development

Requirements:

  • B.S. in Mechanical Engineering or related field
  • 5 to 7 years of hands-on experience in life-sciences instrumentation and/or medical device development. At least 2 years in a managerial or leadership role
  • Proven track record of delivery of instruments, automation systems and capital equipment in life-sciences, semiconductor, or related fields
  • Confident in mechanical design process and excels in SolidWorks, or similar CAD softwares
  • Strong understanding of Design for Manufacturability and Maintainability while ensuring safety is a priority
  • Strong understanding of fluid dynamics and the related components and manufacturers
  • A track record of taking a product from conception to launch and beyond
  • Experience with the design and selection of fluidics, mechanisms, motion, robotics and thermal systems common to life-sciences instrumentation
  • Proven track record of leading cross-functional projects, particularly within a regulated environment
  • Excellent verbal and written communications skills including presentation of technical content to both peers and leadership through presentations and design reviews
  • Willingness to provide mentorship and hands-on assistance in the lab
  • Willingness to work in a startup environment and adapt to changing needs and priorities
  • A driven outlook and with a strong desire to succeed

Nice to Have:

  • MS in Mechanical Engineering or related field
  • Experience with high-pressure equipment, chemical reactors, oligonucleotide synthesis, microfluidics and/or analytical instrumentation
  • Experience with automation equipment and PLC driven systems
  • Basic programming and data skills, such as Python
  • Experience in a start-up environment
  • Experience contributing to the successful launch of a life-sciences instrument or automation system

About Us:

Synthego is a genome engineering company that enables the acceleration of life science research and development in the pursuit of improved human health.

Based on a foundation of engineering and chemistry, Synthego leverages automation and machine learning to synthesize high-quality CRISPR reagents for science at scale.

Synthego's mission is to enable agile life science research and development from discovery through clinical trials by providing scientists with comprehensive CRISPR solutions for each phase coupled with full technical and regulatory support from industry-leading experts.

With its technologies cited in hundreds of peer-reviewed publications and utilized by thousands of commercial and academic researchers and therapeutic drug developers, Synthego is at the forefront of innovation, enabling the next generation of medicines by delivering genome editing at an unprecedented scale.

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