Principal Associate Scientist, LNP Discovery

4 weeks ago

Étreux, Hauts-de-France, United States Strand Therapeutics Full time

Company Overview:

Strand Therapeutics is a clinical-stage biotechnology company that leverages synthetic biology to develop innovative mRNA-based immunotherapies. Our mission is to revolutionize the treatment of diseases by harnessing the power of mRNA technology.

We are a team of passionate biological engineers and scientists who are dedicated to advancing the field of mRNA delivery. Our technology is therapeutic-area and mRNA modality agnostic, allowing us to develop targeted therapies for a wide range of diseases.

Our lead program, STX-001, is currently being evaluated in a phase 1 clinical trial for solid tumors. We are committed to advancing our platform and capabilities to bring life-changing treatments to patients.

Job Summary:

We are seeking a highly motivated and innovative Scientist to join our LNP Discovery team. The successful candidate will have experience in the formulation and characterization of LNPs and will be responsible for advancing our mRNA delivery platform and capabilities.

The ideal candidate will have a strong background in pharmaceutical sciences, biomedical engineering, or a related field, and will be able to work in a fast-paced, cross-collaborative environment. They will be responsible for contributing to LNP innovation, engineering, and process screening, as well as characterizing the physiochemical properties of LNPs and components.

Key Responsibilities:

• Advance Strand's mRNA delivery platform and capabilities

• Contribute to LNP innovation, engineering, and process screening to support pipeline programs

• Characterize the physiochemical properties of LNPs and components using standard or newly developed in-house assays

• Evaluate the delivery capability of LNPs using standard or newly developed cell-based assays

• Execute LNP composition optimization and screening assays

• Compile data reports and communicate the results with relevant team(s)

• Produce LNP formulations to support internal and partnered programs

• Research and identify new opportunities and novel project ideas related to mRNA delivery that support Strand's vision

Qualifications:

• B.S. or Advanced Degree in Pharmaceutical Sciences, Biomedical Engineering, Chemical Engineering, or other relevant scientific discipline

• 5-6+ years of experience with a focus on discovery & development of LNP formulations with nucleic acid-based payloads required

• Experience with production and analytical characterization of mRNA LNPs (DLS measurement, RiboGreen assay, luciferase assay, etc.)

• Experience with mammalian cell culture and cell-based assays is highly preferred

• Familiarity with high throughput screening of mRNA LNPs would be a plus

• Excellent knowledge of the scientific literature in the field of mRNA delivery

• Highly analytical, decisive, and goal-oriented while maintaining the highest scientific and ethical standards

• Ability to quickly adapt to change and thrive in a dynamic and entrepreneurial early-stage environment

• Strong team player with excellent oral and written communication skills and a demonstrated ability to work independently

What We Offer:

Strand Therapeutics offers a fast-paced, entrepreneurial, team-focused small company environment. We offer a top-notch benefits package (health, dental, life, open PTO, onsite lunch catering, commuter support, and more) and work/life flexibility and integration. Being part of the Strand team allows you to become part of a small team that supports professional development while working together to meet Strand's goals.

Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status, or any other basis protected by applicable law.

  • Senior Scientist, mRNA Delivery

    4 weeks ago

    Étreux, Hauts-de-France, United States TBWA\Chiat\Day Full time

    Job Summary:We are seeking a highly motivated and innovative candidate for the role of Principal Associate Scientist, LNP Discovery. The successful candidate will have experience in the formulation and characterization of LNPs and will contribute to the advancement of Strand's mRNA delivery platform and capabilities.The ideal candidate will have a strong...

  • Research Scientist Inflammation Discovery Research

    4 weeks ago

    Étreux, Hauts-de-France, United States Takeda Pharmaceutical Company Ltd Full time

    About the Role:The Gastrointestinal and Inflammation (GI2) Drug Discovery Unit at Takeda Pharmaceutical Company Ltd is seeking a Research Associate Scientist to join our biology and cross-functional discovery teams. The successful candidate will be responsible for generating and executing preclinical development strategies to support candidate selection,...

  • Associate Director Research In Vitro Antibody Discovery Expert

    4 weeks ago

    Étreux, Hauts-de-France, United States Takeda Full time

    About the Role: At Takeda, we are a forward-looking, world-class R&D organization dedicated to unlocking innovation and delivering transformative therapies to patients worldwide. As an Associate Director for Research, In Vitro Antibody Discovery, you will be responsible for leading our antibody discovery team, driving cutting-edge research, and advancing...

  • Scientist/Senior Scientist

    4 weeks ago

    Étreux, Hauts-de-France, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics is a pioneering company that leverages the emerging discipline of biomolecular condensates to drive innovative drug discovery. Our team is seeking a highly skilled Scientist or Senior Scientist to join our Discovery Platform Team and contribute to the development of cutting-edge high content screening and high-throughput small molecule...

  • Senior Research Scientist, In Vivo Study Specialist

    4 weeks ago

    Étreux, Hauts-de-France, United States Fable Therapeutics Full time

    About Us:Fable Therapeutics is a biotechnology company that leverages cutting-edge protein language models to develop innovative therapeutic solutions.We are seeking a highly skilled and motivated scientist to join our team and contribute to the design and execution of in vivo studies for drug discovery.In close collaboration with our machine learning team,...

  • Senior Biologics Research Scientist

    4 weeks ago

    Étreux, Hauts-de-France, United States Fable Therapeutics Full time

    About Us:Fable Therapeutics is a pioneering biotechnology company that leverages cutting-edge protein language models to develop innovative therapeutic solutions. Our team of leading scientists and entrepreneurs is dedicated to harnessing the power of biology and computation to tackle complex medical challenges.Backed by a significant investment, Fable is...

  • Associate Director Research In Vitro Antibody Discovery Expert

    4 weeks ago

    Étreux, Hauts-de-France, United States Takeda Pharmaceuticals Full time

    About the RoleAt Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. As an Associate Director Research In Vitro Antibody Discovery, you will have extensive expertise and a comprehensive understanding of antibody discovery, optimization through in vitro based methodologies...

  • Research Scientist, Liver Disease Researcher

    4 weeks ago

    Étreux, Hauts-de-France, United States Takeda Pharmaceutical Company Ltd Full time

    About the RoleWe are seeking a highly skilled Research Scientist to join our team focused on the validation of novel targets and the evaluation of drug candidates for the treatment of chronic fibroinflammatory liver diseases.As a Research Scientist, you will apply your expertise in executing in vitro studies relevant to fibroinflammatory liver disease...

  • Senior Research Scientist, Molecular Biology

    1 month ago

    Étreux, Hauts-de-France, United States QLD Biotherapeutics Inc Full time

    Job Title: Senior Research Scientist, Molecular BiologyJob Location: Boston Job Summary We are seeking a highly motivated Senior Research Scientist to join the In Vitro Biology team at QLD Biotherapeutics Inc. The successful candidate will work closely with an experienced drug discovery and development team to perform In Vitro experiments, such as establish...

  • Senior Staff Scientist, Single-Cell Biology Expert

    4 weeks ago

    Étreux, Hauts-de-France, United States Kojin Therapeutics Full time

    Senior Staff Scientist, Single-Cell Biology ExpertKojin Therapeutics, Inc. is a pioneering biotech company harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop innovative treatments for various diseases. As a Senior Staff Scientist, Single-Cell Biology Expert, you will play a crucial role in establishing our single-cell...

  • Principal Architect

    1 month ago

    Étreux, Hauts-de-France, United States Jobot Full time

    Science & Technology Principal Architect R.A. AIA (Hybrid)This is a unique opportunity to lead our Science & Technology Studio, collaborating with a talented group of designers and architects. As a Principal Architect, you will be responsible for leading the programming and design of multiple projects, engaging the larger healthcare studio in thought...

  • Biologics Research Director

    1 week ago

    Étreux, Hauts-de-France, United States Takeda Pharmaceuticals Full time

    About the Role:Takeda is seeking an exceptional Biologics Research Director to lead our team of scientists in the discovery and development of innovative biologics therapies. As a key member of our Global Biologics organization, you will be responsible for leading biologics programs from early discovery through candidate nomination and selection.With a...

  • Associate Director of Translational Research

    1 month ago

    Étreux, Hauts-de-France, United States Tempus AI Inc. Full time

    Job Title: Associate Director, Translational ResearchTempus AI Inc. is seeking a highly skilled Associate Director to lead our Translational Research team. As a key member of our Real-World Data Science organization, you will be responsible for designing and implementing research studies, analyzing data, and providing actionable insights to guide discovery...

  • Scientist - Analytical Development (AD) Specialist

    1 month ago

    Étreux, Hauts-de-France, United States Takeda Pharmaceutical Full time

    About the RoleTakeda is seeking a highly skilled Scientist - Analytical Development (AD) to join our team in Boston, MA. As a key member of our Analytical Development team, you will be responsible for leading efforts in development of analytical methods, implementation of evolving scientific technology, and influencing strategic planning within AD and across...

  • Litigation Associate

    4 weeks ago

    Étreux, Hauts-de-France, United States Trustpoint Full time

    Job Title: Litigation AssociateJob Summary: We are seeking an experienced Litigation Attorney to join our team in Boston. The ideal candidate will have a strong background in litigation, excellent communication skills, and a commitment to client service.Key Responsibilities:Manage cases from inception through discovery and trial preparation.Attend...

  • Data Analyst and Research Scientist in Genetic Epidemiology

    4 weeks ago

    Étreux, Hauts-de-France, United States Mass General Brigham Full time

    Data Analyst and Research Scientist in Genetic Epidemiology**Job Summary**Massachusetts General Hospital is seeking a highly motivated Data Analyst and Research Scientist in Genetic Epidemiology to join their interdisciplinary research teams. This role offers a unique opportunity to work on cutting-edge genetic epidemiology and statistical genetics projects,...

  • Director Translational Biomarker Lead Liver Disease

    4 weeks ago

    Étreux, Hauts-de-France, United States Takeda Pharmaceuticals Full time

    About the Role:Takeda Pharmaceuticals is seeking a highly skilled Director Translational Biomarker Lead to join our team in Boston, MA. As a key member of our Translational Biomarker Research team, you will provide scientific and strategic leadership in developing translational biomarker strategies, plans, and implementation for diseases in liver (NASH,...

  • Biostatistics Leadership Position

    4 weeks ago

    Étreux, Hauts-de-France, United States Understanding Recruitment Full time

    Transformative Biostatistics LeadershipAre you a visionary Biostatistician seeking to drive impactful decisions in the biotechnology sector? Our client, a leading company in the field, is looking for a talented Director, Biostatistics to spearhead data-driven discoveries and advancements in biotech.Key Responsibilities:Data Analysis: Lead the analysis and...

  • Executive Director and Head of Structural Biology

    1 month ago

    Étreux, Hauts-de-France, United States Takeda Pharmaceutical Company Ltd Full time

    Job SummaryTakeda is seeking a visionary leader to spearhead its Structural Biology organization, driving innovation and excellence in protein structure determination, molecular modeling, and drug-target interaction validation. As Executive Director and Head of Structural Biology, you will lead a team of experts in X-ray crystallography, Cryo-EM, and...

  • Research Director of Inflammatory and Autoimmune Diseases

    1 week ago

    Étreux, Hauts-de-France, United States Takeda Pharmaceutical Full time

    About the RoleThe Takeda Pharmaceutical company is seeking a highly skilled and experienced Director of Inflammatory Bowel Disease Research to join our innovative Gastrointestinal and Inflammation (GI2) Drug Discovery Unit.This is an exceptional opportunity for a talented scientist to lead internal and external partnered research from target identification...