Gene Therapy Research Specialist
1 day ago
Poseida Therapeutics, Inc. is a clinical-stage biopharmaceutical company that utilizes its unique genetic engineering platform technologies to create next-generation cell and gene therapies with the potential to cure severe diseases early in life. We are passionate about making an impact on patients' lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases.
Job DescriptionWe are searching for a skilled Research Scientist (Research Scientist I, Research Scientist II or Sr. Research Scientist) to join our Gene Therapy team in San Diego, CA. This position offers an exciting opportunity to discover and develop next-generation products using Poseida's best-in-class genome editing, gene insertion, and delivery technologies.
Responsibilities:- Manage and execute in vivo pharmacology work from discovery to drug candidate nomination, working closely with formulations, analytical chemistry, molecular engineering, and translational teams.
- Lead in vivo pharmacology activities in rodents and large animals for Poseida's in vivo genetic medicines team, comprising platform discovery, feasibility assessment, therapeutic proof-of-concept, and candidate nomination.
- Plan and execute studies in rodents and large animals to characterize the in vivo pharmacology (PK/PD, biodistribution), toxicology, safety, and efficacy of Poseida's genetic medicines systems, including hands-on work designing/validating/implementing in vivo disease models.
The ideal candidate will have a Ph.D. in a scientific discipline (e.g., molecular biology, cell biology, pharmacology, toxicology, immunology, or other relevant scientific field) with up to 5 years of relevant experience. Strong hands-on experience with complex drug formulations, such as nanoparticles and viral vectors, for in vivo gene therapy is highly valued. Experience with routine assays (qPCR and/or ddPCR, immune-staining (IHC/IFC), immunoassays (ELISA, MSD, Luminex) and Western blot) is also desirable.
BenefitsWe offer a competitive salary and benefits package, including health insurance, retirement savings plan, and paid time off. The salary range for this position is $108,000 - $150,000 per year, depending on experience and qualifications.
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