Chief Scientific Officer

4 weeks ago

Pasadena, California, United States AcuraStem Full time
Job Summary

AcuraStem is seeking a highly experienced Chief Scientific Officer to lead its neuroscience research and development efforts. The successful candidate will have a strong background in neurodegenerative disease modeling, RNA therapeutics, and drug development.

The CSO will be responsible for advancing AcuraStem's mission of discovering and developing effective treatments for neurodegenerative diseases. This will involve managing and advancing the company's scientific portfolio, discovering and validating new targets, and advancing existing therapeutic programs through development into IND-enabling and early clinical studies.

The CSO will also be responsible for building, directing, mentoring, and evaluating the research team. Excellent communication and leadership skills are essential for this role, as the CSO will need to communicate the company's science to the scientific, patient, and investment communities.

Key Responsibilities:

  • Define the scientific strategy in line with the company's objectives
  • Communicate with key stakeholders to get support for the neuroscience strategy
  • Serve as the scientific face of the company, delivering scientific presentations and drafting grant proposals and investor presentations
  • Build and maintain strong expertise in the current and emerging disease etiology knowledge base for neuroscience indications of interest
  • Manage projects for a cross-functional team, ensuring timely delivery of high-quality results
  • Oversee the improvement and expansion of the company's technology platform
  • Lead the iPSC disease modeling team to improve experimental processes and assays, and extension to new indications
  • Manage cross-functional teams in the discovery and prioritization of new targets
  • Manage the R&D leads to advance therapeutic candidates to development candidate status
  • Lead the translational team, covering biomarker development, PK/PD modeling, and IND-enabling toxicity studies
  • Establish the initial clinical strategy and plans for the programs
  • Creatively bootstrap new programs for which funding has yet to be allocated
  • Collaborate with program management and finance on project control
  • Collaborate with business development on internal and external scientific diligence

Qualifications:

  • PhD with 15+ years of experience in academic, startup, and large biopharma settings
  • Expertise in neuroscience, iPSC disease modeling, neurobiology, and RNA therapeutics
  • Successful track record of delivering therapeutics into clinical trials and beyond
  • Experience building biotech pipelines and R&D organizations
  • Prior experience leading an R&D therapeutic area and having broad R&D functional experience and understanding
  • Therapeutic area expertise in neurodegeneration, neurodevelopment, and rare neuro conditions
  • Strong background in drug development, including target screening, new target nomination, and validation
  • Extensive knowledge and experience in all phases of research and development, including clinical and regulatory expertise of therapeutics, including antisense oligonucleotides (ASO)

What We Offer:

  • Competitive salary range: $200,000 - $300,000
  • Comprehensive benefits package, including medical, dental, and vision coverage
  • 401(k) plan with company match
  • Opportunities for professional growth and development

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