Senior Chemistry Process Developer
4 days ago
We are seeking a highly skilled Senior Chemistry Process Developer to join our team at Willow Biosciences. This full-time position is based in Sunnyvale, CA, USA, and offers a competitive salary package, including benefits and opportunities for professional development.
Job DescriptionThis role involves developing biobased processes for manufacturing high-value ingredients, utilizing strong organic chemistry skills, experience with enzyme-based chemical processes, and knowledge of analytical instrumentation.
- Main Responsibilities:
- Design and execute biocatalytic and bioconversion reactions at bench scale
- Develop scalable bio-based processes for both bioconversion and isolation and purification steps
- Collaborate with assay team to implement designed processes in high-throughput screening and evaluate engineered enzymes and strains at bench scale
- Offer strategic recommendations for enzyme and strain engineering and fermentation process decisions
- Structural characterization of biosynthetically derived molecules and evaluation of purity
- Design, establish, and validate scalable and safe chemical processes leading to pharmaceutical intermediates, APIs, and other value-added chemical products
- Synthesis of organic substrates, intermediates, and products as required
- Development and use of analytical techniques as required
- Proper record-keeping and data analysis
- Preparation of documentation for tech transfer of chemical processes
- Work closely with manufacturing organizations for scale up of internal processes
- Effectively communicate/present work and analysis to audiences with diverse technical backgrounds
- Evaluate innovative technologies that will further advance/enable project goals
- Mentor research associates/associate scientists
The ideal candidate should have:
- Experience developing enzyme-based chemical processes (e.g., biocatalysis, bioconversions)
- Strong knowledge of organic chemistry principles (e.g., chirality, catalysis, kinetics, thermodynamics, mechanism, synthesis) in addition to strong organic chemistry skills (e.g., chemical handling, purification, and analysis)
- Knowledge using analytical instrumentation (e.g., HPLC, GC, MS)
- Knowledge and ability to solve the structures of unknown compounds
- Understanding of process chemistry (e.g., reaction up-scaling, safety, and downstream processing)
- Bachelor's or master's degree in chemistry, biochemistry, or related field
- 2+ years of relevant work experience
Willow Biosciences is a synthetic biology company focused on the development of bio-based processes for manufacturing ingredients. Our fully integrated processes are more sustainable, secure, and cost-effective than traditional extraction or chemical synthesis routes and typically provide final products in higher purity.
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