Senior Research Scientist

1 day ago


Watertown, Massachusetts, United States Apellis Full time
Job Overview

We are seeking a highly skilled and motivated individual to join our research team at Apellis in Watertown, MA.

About the Role

This is a laboratory-based position that requires standing for prolonged periods of time. The primary responsibility of this position will be to conduct sample preparation, analysis, and method testing for in vivo and in vitro pharmacology studies on various platforms such as protein assays (using Simoa/Quanterix, Meso Scale Discovery (MSD), ELISA, Jess/western etc.) and mRNA assays (utilizing platforms such as qPCR, ddPCR, etc.) across a wide range of matrices/species.

Key Responsibilities
  • Conduct quality sample preparation and analysis on various platforms such as Simoa/Quanterix, Meso Scale Discovery (MSD), ELISA, Jess/western, qPCR and ddPCR to evaluate in vitro and in vivo samples across a variety of biological matrices/species.
  • Develop and implement biomarkers assays relevant for neurologic and ocular diseases and therapeutic targets.
  • Effectively communicate experimental results to study directors and management, presenting data at project team meetings as needed.
  • Use critical thinking skills to analyze experimental data and comply with proper documentation practices via electronic laboratory notebook.
  • Contribute to experimental designs and assay development for internal and externalized projects.
  • Apply basic scientific principles to perform literature searches and extract relevant information from published protocols.
  • Participate in shared lab duties (such as reagent preparation, lab inspection, instrument maintenance, etc.) and lab meetings.
Education and Experience Requirements
  • Masters or Bachelor's degree in biochemistry, pharmacology, or life sciences-related program.
  • Masters plus 3 years or Bachelor's plus 5 years of direct bench research experience, preferably in biopharmaceutical industry setting.
  • Solid hands-on experience in immunoassay analysis and method testing required, with experience using MSD, and/or Quanterix platforms highly preferred.
  • Knowledge of and ability to troubleshoot assay matrix effects, specificity, and limits of quantitation/detection required.
  • Other cell biology, molecular biology, and biochemistry techniques (such as cell culture, DNA and RNA extraction, qPCR, Western blot/WES/JESS, and ELISA and other ligand binding assays) a plus.
What We Offer

A competitive salary of $80,000 - $110,000 per year, depending on experience, plus benefits package including comprehensive health insurance, retirement plan, paid family leave, and more.

A chance to work in a dynamic and innovative environment with a global impact on treating serious diseases.

An opportunity to develop your skills and expertise in the field of biotechnology and pharmaceuticals.

Travel Requirements and Work Environment
  • This position involves up to 15% travel.
  • This job operates in a professional office environment and routinely uses standard office equipment such as computers, phones, photocopiers, filing cabinets, and fax machines, as well as laboratory equipment.


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