Senior Research Associate

1 week ago


San Mateo, California, United States ACL Digital Full time
About the Role

We are seeking a highly motivated and talented Senior Research Associate to join our Immuno-oncology group at ACL Digital. As a key member of our research team, you will contribute to the discovery, research, and development of novel immunotherapeutic agents to address unmet medical needs of cancer patients.

Key Responsibilities
  • Independently plan, execute, analyze, and interpret in vitro and in vivo immunological assays that support the initiation and/or advancement of drug candidate projects.
  • Proactively evaluate new technologies and develop new assays to accelerate early-stage discovery activities and/or enhance our understanding of disease mechanisms.
  • Manage multiple projects simultaneously and work cross-functionally with colleagues in the oncology, protein engineering, chemistry, translational medicine, biomarker, and clinical groups.
  • Presents research findings and recommendations to senior staff and contribute to the preparation of research reports, manuscripts, INDs, and patent filings.
Requirements
  • Master's degree with 3+ years of experience, or Bachelor's degree with 5+ years of experience in immunology, immuno-oncology, cell biology, molecular biology, or biochemistry in industry or academia.
  • Direct experience in research drug discovery and target identification/validation in oncology or immuno-oncology is highly desirable.
  • Strong understanding of immune cell biology, including T cell and myeloid cells.
  • Proficiency in primary T cell-based functional assays such as activation, proliferation, and cytotoxicity.
  • Experience in conducting and optimizing cell-based assays, as well as performing studies to assess immune responses in human and animal models (including whole blood, PBMCs, and various primary cell subsets).
  • Hands-on experience in general molecular and cell biology methods, including mammalian cell culture, multi-color flow cytometry, western blot, ELISA/Luminex/MSD, and CRISPR technology.
  • Attention to detail with excellent organizational and record-keeping skills is a requirement.
  • Excellent communication and interpersonal skills are required.


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