Executive Director, Immunobiology

1 week ago

Hartford, United States EvolveImmune Therapeutics, Inc. Full time

EvolveImmune Therapeutics is a next-generation, development-stage immune-oncology company which is developing novel trispecific T cell engagers with integrated CD2 costimulation to optimize anti-tumor immunity to overcome the therapeutic challenges of cancer cell resistance. Our lead program based on our EVOLVE therapeutic platform will enter the clinic in 2025. We conduct our R&D, including internal protein engineeringandbiotherapeuticsdiscovery,immunobiology,andtranslationalsciences,atourdedicated,state- of-the-art laboratories located in Branford, CT. The Role The company seeks an entrepreneurial, industry-experienced, and immunology-focused leader to serve as Executive Director of Immunobiology. Extensive experience in T cell engager drug development, including CD3 bispecifics or costimulation immunotherapies, and immune pharmacology is essential. Extensive experience in drug program leadership, including T cell engager lead assessment through tumor killing, cytokine production, T cell exhaustion assays, multiparameter flow cytometry immune cell analysis, in vivo pharmacodynamics, and exploration of immune microenvironment modulation in humanized mouse models to support lead prioritization through candidate nomination is required. This role will lead our immunobiology drug development team activities from discovery to candidate nomination. This includes designing and implementing functional in vitro human assay systems for successful lead prioritization, selecting preclinical models to support precision medicine strategies, and designing in vivo pharmacologystudiestoexploredrugcandidateperformance,supportcandidatenomination,andextendinsights intomechanismsofdifferentiation.Theywillalsoworkcloselywithourbiotherapeuticsandtranslationalresearch teamstodrivecandidateselectioneffortsandIND-enablingstudies.Thisrolealsoincludesmanaginginteractions with specific academic or corporate partners and overseeing the immunobiology activities of broader external research partnerships.Experience in leading T cell engager therapeutic research and development programs is required. Strong verbal and written communication skills are necessary, as is a proven track record of scientific and project achievements in biopharma. Responsibilities Working closely with our protein design and engineering colleagues, establish functional ex vivo and in vivo studies to evaluate protein therapeutics and establish data-driven decisions for drug lead and candidate selection. Oversee functional immune co-culture assays, including mixed lymphocyte reaction, T cell-tumor cell cytotoxicityassays,andotherphenotypicassessmentsofgeneticallymodifiedimmunecellstoidentify phenotypes associated with a knockout or genetic modification of genes of interest. Developandexecutetargetexpressionassessmentandfunctionalstudieswithpatientsamplesto delineate differentiation opportunities for emerging and selected lead molecules. Working closely with our in vivo pharmacology team to design studies to evaluate drug candidate in vivo characteristics such as drug distribution properties, pharmacokinetic profile, early safety readouts, and disease state modifications in murine and humanized cancer models. Ensurethatbiologyteammemberskeepdetailedrecordsofexperimentsinelectronicnotebooks, analyzedata, and prepare and deliver presentations to research team members and our executive leadership team members. Qualifications and Experience PhD in Immunology or related field with postdoctoral experience and 15+ years of industry experience Experience in T cell engager immunotherapies in a drug development setting, including technical experience in assaying tumor killing, cytokine release and immune cell function ex vivo and invivo . Technicalexpertisetoassistteammembersinperformingmulti-colorflowcytometryandFluorescence Assisted Cell Sorting (FACS). Proven ability to manage drug discovery and development teams as demonstrated by a strong publication, patent, and/or drug development record in T cell engager therapies. EvolveImmune Therapeutics requires all employees to be fully vaccinated against COVID-19. You may seek reasonable accommodations for medical and religious reasons. However, your application is no guarantee that such accommodations will be made available. EvolveImmune will provide a competitive compensation package based on the candidate’s experience level. EvolveImmune Therapeutics, Inc. is an equal opportunity employer. #J-18808-Ljbffr

  • Executive Director

    1 week ago

    Hartford, United States Atria Senior Living Full time

    Responsibilities The Executive Director is responsible for leading the community's day-to-day operations, including full profit and loss responsibility. The Executive Director plans, implements, and evaluates all aspects of operations. This individual recruits and trains team members and has direct supervisory responsibility for a high performing team of...

  • Executive Director

    1 week ago

    Hartford, United States Atria Senior Living Full time

    Responsibilities The Executive Director is responsible for leading the community's day-to-day operations, including full profit and loss responsibility. The Executive Director plans, implements, and evaluates all aspects of operations. This individual recruits and trains team members and has direct supervisory responsibility for a high performing team of...

  • Executive Director,

    1 week ago

    Hartford, United States Service Employee Intl. Union Full time

    January 2024 NOTE: Position is open as of December 2024 Position Description Job Title: Executive Director Reports to: 1199NE Training & Upgrading Fund Board of Trustees Employment Status: Full-time, exempt Compensation: Commensurate of background and experience; includes generous benefit package To apply: Submit a letter of interest and resume to: Jesse...

  • Executive Director,

    1 week ago

    Hartford, United States Service Employee Intl. Union Full time

    January 2024 NOTE: Position is open as of December 2024 Position Description Job Title: Executive Director Reports to: 1199NE Training & Upgrading Fund Board of Trustees Employment Status: Full-time, exempt Compensation: Commensurate of background and experience; includes generous benefit package To apply: Submit a letter of interest and resume...

  • Executive Director of Architecture

    7 days ago

    Hartford, Connecticut, United States The Travelers Companies, Inc. Full time

    Job SummaryWe are seeking a highly experienced Executive Director of Architecture to lead our technology transformation efforts in Personal Insurance. As a key member of our Enterprise Architecture and Emerging Technology leadership team, you will drive the creation of a technology target state that aligns with our business strategy.Key...

  • Executive Director

    3 weeks ago

    East Hartford, Connecticut, United States Procare HR Full time

    Executive Director Role at Procare HR Front Royal CampusProcare HR is seeking an experienced Executive Director to lead our Front Royal Campus. As the Director of Operations, you will be responsible for establishing a clear vision and strategic direction that prioritizes the well-being and satisfaction of our residents. You will foster a culture of...

  • Director of operations

    2 weeks ago

    Hartford, United States The ExeQfind Group Full time

    The ExeQfind Group is managing a confidential search for an experienced manufacturing operations executive for the role of Director of Operations for our client’s multi-site manufacturing business in North America. The successful hire will have the opportunity to reside near one of our client’s multiple manufacturing sites located in the Southwestern US,...

  • Account Executive

    1 day ago

    Hartford, United States East Coast Facilities, Inc. Full time

    Major Areas of Focus Account Executives (AE) primarily focus on new business development. Account Executives build and service portfolios of clients in assigned geographic markets, and customer sales verticals. Once they close a new service agreement or project sale, the operations team handles the entire fulfillment process. The customer relationship...

  • Account Executive

    2 days ago

    Hartford, United States East Coast Facilities, Inc. Full time

    Major Areas of Focus Account Executives (AE) primarily focus on new business development. Account Executives build and service portfolios of clients in assigned geographic markets, and customer sales verticals. Once they close a new service agreement or project sale, the operations team handles the entire fulfillment process. The customer relationship...

  • Executive Assistant

    2 weeks ago

    Hartford, United States TEKsystems Full time

    Job DescriptionJob DescriptionThe successful candidate will provide a variety of standard administrative support functions and will be involved in and help coordinate team meetings, special operations projects, and executive initiatives. The chosen candidate will be self-motivated, have excellent interpersonal skills, and the ability to build professional...

  • Senior Sales Director

    2 days ago

    Hartford, Connecticut, United States US1225 FreshPoint Connecticut, LLC Full time

    Job DescriptionThis is a highly challenging and rewarding role for a seasoned sales professional. As Sales Director at US1225 FreshPoint Connecticut, LLC, you will be responsible for driving revenue growth and developing strategic plans to meet our short and long-term business objectives.About the JobWe are seeking a talented Sales Director who can lead and...

  • Strategic Innovation Director

    3 days ago

    Hartford, Connecticut, United States CVS Health Full time

    Unlocking Healthcare ExcellenceWe are seeking a highly skilled Strategic Innovation Director to join our team at CVS Health. In this role, you will play a crucial part in shaping the future of healthcare by driving strategic initiatives that deliver exceptional results.About the RoleThis is an exciting opportunity for a seasoned professional with a strong...

  • Leadership Opportunity in Front Royal, VA

    7 days ago

    East Hartford, Connecticut, United States PROCare HR Full time

    About UsLavender Hills Front Royal Campus is dedicated to enhancing the lives of our residents through exceptional lifestyle offerings and heartfelt care. We prioritize compassion and quality of life for all.Salary Range: $60,000 - $80,000 per year, with credit given for experienceJob Description: As an Executive Director, you will establish a clear vision...

  • Activity Director

    7 days ago

    Hartford, Connecticut, United States Hebrew Center for Health & Rehabilitation Full time

    Director of Therapeutic RecreationA comprehensive Therapeutic Recreation Director role at a leading rehabilitation facility. Develop and oversee vibrant activities programs, collaborating with interdisciplinary teams to enhance residents' well-being and happiness.Main Responsibilities:Developing and implementing therapeutic recreation programs that cater to...

  • Senior Hardware Sales Director

    7 days ago

    Hartford, Connecticut, United States PAR Full time

    We are seeking an experienced and strategic sales leader to drive revenue growth for our hardware products and services at PAR Technology.This highly visible role within the organization provides an opportunity for the right individual to play a significant role in our Company's success, driving operational efficiency across all levels and fostering a...

  • Strategic Cloud Services Director

    7 days ago

    Hartford, Connecticut, United States Oracle Full time

    Lead Global Cloud Operations as Oracle Software Development DirectorJob Summary:We are seeking a seasoned leader to drive global cloud operations and engineering excellence as an Oracle Software Development Director. The ideal candidate will have extensive experience in cloud infrastructure engineering, software development, and team leadership.Key...

  • Director Investment Controllership- Derivatives

    3 months ago

    HARTFORD, United States MassMutual Full time

    Director Investment Controllership- Derivatives Controllers Organization of Corporate Finance Full-TimeNew York, NY - preferred locationWill also consider candidates based in Boston, MA or Springfield, MA About the Corporate Controller Organization:The Controllers Organization is responsible for delivering on the foundation of credibility and control of the...

  • Director, Cloud Operations

    2 weeks ago

    Hartford, United States NASCO Full time

    NASCO Director, Cloud Operations Hartford, Connecticut Apply Now As the Director of Cloud Operations at NASCO, you'll be at the forefront of driving technical excellence and innovation in cloud services, with a strong emphasis on AWS. The Director is responsible for the management and optimization of cloud-based systems to ensure they run smoothly, securely,...

  • Director of HR Benefits and Operations

    2 weeks ago

    Hartford, United States Trinity College (Connecticut) Full time

    Posting Details Title: Director of HR Benefits and Operations Department: Human Resources Regular or Temporary: Regular Hours Per Week: 40 FLSA Determination: Exempt Weeks Per Year: 52 Open Date: 10/18/2024 Open Until Filled: Yes Full or Part Time: Full Time Position Summary: Trinity College seeks a staff that reflects the changing demographics of our...

  • Senior Executive Leadership Position

    7 days ago

    Hartford, Connecticut, United States WTW Full time

    About the RoleThis is an outstanding opportunity to join WTW as a Senior Director and take on a leadership role in driving business development and operations. As a key member of our team, you will be responsible for developing and executing business strategies, leading client relationships, and driving operational excellence.Key ResponsibilitiesBusiness...