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Drug Mechanism of Action

4 months ago

Frederick, United States Frederick National Laboratory Full time

**Drug Mechanism of Action & Translational Pharmacology Scientist**

Job ID: req3944
Employee Type: exempt full-time
Division: Applied & Development Research Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

**PROGRAM DESCRIPTION**
- and co-culture cell-based 2D and 3D in vitro tumor models (e.g., monolayers, spheroids and organoids), and genetically engineered or otherwise manipulated cell lines or mouse models that are immunocompetent or harbor particular defects of the immune system. It is also likely that wide-ranging experimental approaches will be required to test the MOA hypotheses, including enzymatic studies, labeling of cell types (e.g., fluorescent markers or genetic barcodes), proteomics and single-cell RNA sequencing, spatial transcriptomics, and high-resolution tissue imaging. Success in this role will require extensive knowledge of pharmacology and cancer biology as well as experience with wide-ranging experimental methods and model systems suitable for pharmacodynamic studies.

**KEY ROLES/RESPONSIBILITIES**
- Use computational methods to develop hypotheses for the mechanism of action (MOA) of selected drug combinations of programmatic interest to the NCI Division of Cancer Treatment & Diagnosis by systematically analyzing and interpreting a range of preexisting preclinical and clinical data on target inhibition, drug synergy, therapeutic response in laboratory models and/or in cancer patients, predictive and drug-response biomarkers, multi-omics, pharmacokinetics, toxicology, and immunology.
- Design, present, and coordinate the necessary experimental work to fill knowledge gaps as necessary and then to directly test the MOA hypotheses, some of which research will be collaborative work within a team as well as with other groups, including the FNLCR Molecular Characterization Laboratory (MoCha), Proteomics Characterization Laboratory, Clinical Pharmacodynamic Biomarkers Program, and the NCI Biological Testing Branch.
- Lead and conduct experiments to test and refine the MOA hypotheses of the selected drug combinations by leveraging appropriate experimental methods, technologies, and tumor models.
- Sufficiently define and prove the MOA for drug combinations for manuscripts describing them.

**BASIC QUALIFICATIONS**

**To be considered for this position, you must mínimally meet the knowledge, skills, and abilities listed below**:

- Possession of a doctoral degree in a biomedical field (e.g., D.V.M., D.Sc., M.D., or Ph.D.) from an accredited college or university according to the Council for Higher Education Accreditation (CHEA. Foreign degrees must be evaluated for U.S.
- In addition to the education requirement, a minimum of two (2) years of innovative experimental investigations into drug mechanisms of action that demonstrate the creativity, independent thinking, and talent for converting ideas into laboratory experiments that will be essential for success in this position.
- Productive experience in computational analyses of large data sets, appropriate statistical analytical procedures, and accurate interpretations to provide scientific insights into drug pharmacology and MOA.
- Must be an excellent team player, able to thrive in a collaborative setting, and forward-thinking with exceptional experimental, record-keeping, and problem-solving skills.
- Must have high integrity and standards for research rigor and reproducibility.
- Excellent written and verbal communication, troubleshooting, and organizational skills, including excellent skills at converting laboratory research findings into clear and meaningful presentations and documents.
- Ability to obtain and maintain a security clearance.

**PREFERRED QUALIFICATIONS**
- Formal education, training and experience in bioinformatics, data science, and/or artificial intelligence as applied to drug MOA/pharmacology investigations.
- Productive experience with experimental immunology and/or immunotherapeutics.
- Prior experience in an applied R&D environment, such as a research institute, the pharmaceutical sector, and/or the biotechnology sector.
- Scientific contributions that are relevant to drug MOA such as independently producing research work, authoring and/or co-authoring publications in peer-reviewed scientific journals, and by presenting papers before professional societies.

Commitment to Diversity
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories c